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Targeting Autoimmunity-Associated T cells via AHR Pathway Control
SHORT DESCRIPTION
Use of AHR agonists to inhibit pathogenic Tfh/Tph cell differentiation, potentially reducing disease activity.
INVENTORS
Jaehyuk Choi*
Northwestern University Feinberg School of Medicine, Department of Dermatology **(Now at UT Southwestern)**
Deepak Rao
Brigham and Women's...
Published: 5/7/2026
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Updated: 5/7/2026
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Inventor(s):
Keywords(s): Autoimmune disease, Immunology, Immunotherapy, Inflammation, RA - Rheumatoid arthritis, SLE - Systemic lupus erythematosus, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION
Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma.
INVENTORS
Amy Heimberger*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
* Principal Investigator
NU Tech ID: NU 2025-212
IP...
Published: 5/7/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Orthogonal Synthetic Receptors for IL-23
SHORT DESCRIPTION
Synthetic IL-23 receptors for cell engineering to enable real-time sensing and drive precise autoimmune and cancer immunotherapy interventions.
INVENTORS
Joshua Leonard*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Aaron Morris
William Corcoran
...
Published: 5/8/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Autoimmune disease, Cell engineering, Cell therapy, Diagnostics, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Responsive Probiotic Therapy for Local Detection and Treatment of IBD Flares
SHORT DESCRIPTION
An engineered probiotic that senses intestinal inflammation via calprotectin and locally releases therapeutic antibodies in the gastrointestinal tract only during inflammatory flares.
INVENTORS
Arthur Prindle*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Jonathan...
Published: 5/11/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Autoimmune disease, Biologic, Cell therapy, Diagnostics, Gastrointestinal and Hepatic disease, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Synthetic biology, Therapeutics
Category(s): Life Sciences > Therapeutics
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Wireless, Miniaturized Sensing Platforms for Inflammatory Bowel Diseases
LUNU 2023-223
INVENTORS
John Rogers*
Arun Sharma*
Surabhi Madhvapathy
Matthew Bury
SHORT DESCRIPTION
Miniaturized, implantable temperature sensors for real-time, minimally invasive monitoring of inflammatory bowel diseases.
BACKGROUND
Inflammatory Bowel Disease (IBD), encompassing Crohn’s disease and ulcerative colitis, affects over 10...
Published: 12/22/2025
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Updated: 5/8/2025
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Inventor(s):
Keywords(s): Autoimmune disease, Biomedical, Biotechnology, Devices, Diagnostics, Electronics & Circuits, Gastrointestinal and Hepatic disease, Healthcare, Medical device, Obesity, Sensors, Wireless
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Analytical Device for Sorting Single Cells Based on Secreted Products
NU 2023-084
INVENTORS
Shana O. Kelley*
Zongjie Wang
Mahmoud A. M. Labib
SHORT DESCRIPTION
A high-throughput, cost-effective device for sorting of single cells in a culture and analysis of their secreted products.
BACKGROUND
The demand for cost-effective cell analysis methods is expanding due to the increasing urge for the early detection,...
Published: 11/6/2025
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Updated: 2/1/2024
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Inventor(s):
Keywords(s): Autoimmune disease, Biomedical, Devices, Diagnostics, Drug screening, Personalized medicine
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Immunomodulatory Nanoparticles for the Therapeutic Intervention of Traumatic Brain Injury
NU 2019-030
INVENTORS
John Kessler
Sripadh Sharma
ABSTRACT
There is no decisive treatment for traumatic brain injury (TBI). After the primary trauma, secondary injury, largely mediated by blood-borne immune cells called monocytes, takes place causing damage to surrounding healthy cells. Furthermore, cellular and whole brain swelling (edema) resulting...
Published: 1/14/2026
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Updated: 5/27/2022
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Inventor(s):
Keywords(s): Autoimmune disease, CNS - Central Nervous System, Immunology, Inflammation, Neurologic disease, Neurology, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics
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POP3, a Novel Inflammasome Inhibitor and its Use Of
NU 2010-160 Inventors Christian Stehlik Short DescriptionPOP3 protein as a method to modulate inflammationAbstract Northwestern researchers have identified a new member of the PYD-only protein (POPs) family (POP3) as a specific regulator of ALR inflammasomes, promoting IFN-beta production and reducing IL-1beta and IL-8 production. POP3 has the potential...
Published: 11/6/2025
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Updated: 2/19/2019
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Inventor(s):
Keywords(s): Autoimmune disease, Infectious disease, Inflammation, Therapeutics
Category(s): Life Sciences > Therapeutics
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