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Small molecule inhibits the interaction between tristetraprolin and CNOT1 for therapeutic use in metabolic disorders
NU 2024-057
INVENTORS
Hossein Ardehali*
Jason Shapiro
SHORT DESCRIPTION
Compound that inhibits the interaction between tristetraprolin (TTP) and CCR4-NOT Transcription Complex Subunit 1 (CNOT1) offers potential therapeutic avenue for metabolic disorders by modulating mRNA degradation without inflammatory side effects.
BACKGROUND
Metabolic disorders...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Diabetes, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Small Molecule for Bladder Repair
NU 2021-153
INVENTORS
Arun Sharma*
Matthew Bury
Natalie Fuller
SHORT DESCRIPTION
A small molecule to improve the regenerative outcomes of injured or diseased urinary bladder tissue
ABSTRACT
Northwestern researchers have identified a small molecule that facilitates the repair and restoration of damaged urinary bladder tissue following loss of...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Drug discovery, Small molecule, Therapeutics, Urology
Category(s): Life Sciences > Therapeutics
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Nanotherapy to Treat Intestinal Inflammation
NU 2015-160
PRIMARY INVENTOR
Arun Sharma
SHORT DESCRIPTION
Potent anti-inflammatory nanomolecules to treat chronic intestinal inflammation (ileitis) that is detrimental to tissue function
BACKGROUND
Clinical complications of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) can be observed throughout the digestive tract as tissue...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Gastrointestinal and Hepatic disease, Inflammation, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Therapy for T-Cell Lymphoma
NU2022-104
INVENTORS
Jaehyuk Choi*
Jay Daniels
Jurgen Ruland
Tim Wartweig
SHORT DESCRIPTION
Targeting PD-1 related mechanisms for treatment of aggressive T-Cell lymphomas
BACKGROUND
T-cell non-Hodgkin lymphomas (T-NHLs) are highly aggressive cancers that can be resistant to chemotherapies. The molecular pathogenesis of these cancers remains...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Small molecule
Category(s): Life Sciences > Therapeutics
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Compounds and methods of identifying novel E3 ligases for targeted protein degradation
NU 2023-096
INVENTORS
Ananya Angela Basu
Xiaoyu Zhang*
SHORT DESCRIPTION
A CRISPR-activation screen for discovering E3 ligases amenable to targeted protein degradation, and a novel PROTAC for FBXO22
BACKGROUND
Traditional small molecule drugs function by directly interfering with the activities of proteins. However, many proteins lack suitable...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Drug discovery, Proteomics, Small molecule
Category(s): Life Sciences > Therapeutics
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A new CNS-available formulation HDACi for management of chronic pain
A new CNS-available formulation HDACi for management of chronic pain
NU 2017-031
INVENTORS
Vania A. Apkarian*
Kasturi Haldar
Maria V. Centeno
Suhail Alam
SHORT DESCRIPTION
A novel non-opioid, epigenetic drug for pain relief
BACKGROUND
Chronic pain is a major public health problem, and it is the number one source of disability in the...
Published: 11/11/2025
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Inventor(s):
Keywords(s): Biomedical, Chronic pain, Neurologic disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Pharmacotherapy for Preventing Neurodegeneration
NU 2016-108
INVENTORS
D. James Surmeier*
Steven M. Graves
SHORT DESCRIPTION
Small molecule therapeutics to prevent neurological degeneration associated with other pharmaceutical treatments
ABSTRACT
Methamphetamine and amphetamine are pharmaceutical drugs sometimes used to treat attention definicity hyperactive disorder (ADHD), obesity, and narcolepsy....
Published: 11/6/2025
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Inventor(s):
Keywords(s): Neurodegenerative disease, Neurologic disease, Obesity, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Tricyclic Carbogenic Molecules as Anticancer Agents
NU 2017-120
INVENTORS
Regan Thomson*
Emily Robinson
SHORT DESCRIPTION
Development of a new class of small molecules for the treatment of cancer
ABSTRACT
According to the National Cancer Institute, cancer is among the leading causes of death worldwide. In 2012, there were 14 million new cases and 8.2 million cancer-related deaths worldwide. It is...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Novel Fused Pyrrolodiazepine-Based Library with Anti-Cancer Activity
NU 2018-007
INVENTORS
Karl Scheidt*
Gary Schiltz
ABSTRACT
Development of drugs for new and persistent diseases will increasingly rely on the expansion of accessible chemical space to allow exploration of novel molecular targets. Here we report the synthesis of a library of novel fused heterobicyclic small molecules based on the 1,4-diazepine...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Combination Treatment to Reduce Pathological Proteins in Neurodegenerative and Lysosomal Storage Diseases
NU 2021-206
INVENTORS
Joseph Mazzulli*
Iva Stojkovska
SHORT DESCRIPTION
A small molecule combination treatment to improve lysosomal function in neurodegenerative and lysosomal storage diseases
BACKGROUND
Many neurodegenerative disorders are characterized by a collapse in proteostasis, as shown by the accumulation of insoluble protein aggregates...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Biomedical, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Small molecule
Category(s): Life Sciences > Therapeutics
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