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Neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and neurodegenerative disorders
NU 2025-113 (NU 2018-176, NU 2024-250, NU 2025-038)
INVENTORS
Richard Silverman (Weinberg College of Arts and Sciences, Department of Chemistry)
SHORT DESCRIPTION
Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and other cancers with high expression of nNOS (e.g., gliomas, ovarian cancer)...
Published: 2/6/2026
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Cancer/Oncology, Immunotherapy, Melanoma, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Selective DOT1L Protein Degraders for Precision Cancer Therapy
NU 2022-081
INVENTORS
Sarki Abdulkadir (PI)*
Gary Schiltz (PI)*
SHORT DESCRIPTION
A small molecule PROTAC technology that degrades DOT1L protein for targeted treatment of leukemia and prostate cancer.
BACKGROUND
Current cancer treatments, especially for MLL-rearranged leukemia and prostate cancer, face challenges of off-target effects and...
Published: 2/6/2026
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Cancer/Oncology, Leukemia, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Covalent PRC2 Inhibitors for Advanced Cancer Therapeutics
SHORT DESCRIPTION
Covalent inhibitors and proteolysis-targeting chimera (PROTAC) degraders targeting components of the PRC2 complex (EZH and EED) to block both enzymatic and non-enzymatic functions, offering robust anti-tumor efficacy.
INVENTORS
Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)*
Jindan...
Published: 2/6/2026
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Bladder cancer, Breast cancer, Cancer/Oncology, Covalent inhibitor, Lymphoma, Melanoma, PreSeed/Seed, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Novel 2-Imidazolyl-Pyrimidine Inhibitors for Neurodegenerative Disease Therapeutics
NU 2014-101
INVENTORS
Richard Silverman*
Paramita Mukherjee
SHORT DESCRIPTION
This invention introduces novel 2-imidazolyl-pyrimidine scaffolds that inhibit neuronal nitric oxide synthase. It offers potential for drug development targeting Parkinson’s and other neurodegenerative diseases.
BACKGROUND
Neurodegenerative disorders such as...
Published: 12/3/2025
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Inventor(s):
Keywords(s): Biomedical, Materials, Neurodegenerative disease, Neurologic disease, Neurology, Small molecule, Therapeutics
Category(s): Physical Sciences > Materials and Industrial Processes
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Small molecule inhibits the interaction between tristetraprolin and CNOT1 for therapeutic use in metabolic disorders
NU 2024-057
INVENTORS
Hossein Ardehali*
Jason Shapiro
SHORT DESCRIPTION
Compound that inhibits the interaction between tristetraprolin (TTP) and CCR4-NOT Transcription Complex Subunit 1 (CNOT1) offers potential therapeutic avenue for metabolic disorders by modulating mRNA degradation without inflammatory side effects.
BACKGROUND
Metabolic disorders...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Diabetes, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Small Molecule for Bladder Repair
NU 2021-153
INVENTORS
Arun Sharma*
Matthew Bury
Natalie Fuller
SHORT DESCRIPTION
A small molecule to improve the regenerative outcomes of injured or diseased urinary bladder tissue
ABSTRACT
Northwestern researchers have identified a small molecule that facilitates the repair and restoration of damaged urinary bladder tissue following loss of...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Drug discovery, Small molecule, Therapeutics, Urology
Category(s): Life Sciences > Therapeutics
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Nanotherapy to Treat Intestinal Inflammation
NU 2015-160
PRIMARY INVENTOR
Arun Sharma
SHORT DESCRIPTION
Potent anti-inflammatory nanomolecules to treat chronic intestinal inflammation (ileitis) that is detrimental to tissue function
BACKGROUND
Clinical complications of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) can be observed throughout the digestive tract as tissue...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Gastrointestinal and Hepatic disease, Inflammation, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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MEK7 inhibitors for acute lymphoblastic leukemia (ALL) treatment
NU 2023-060
INVENTORS
Karl Scheidt*
Dalton Kim
Meghan Orr
SHORT DESCRIPTION
Rational design of highly potent and selective covalent MEK7 inhibitors
BACKGROUND
Acute lymphoblastic leukemia (ALL) is a deadly blood cancer, the most common hematological malignancy in patients under 14 years of age. Despite advancements in treatment, ALL relapse...
Published: 12/16/2025
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Inventor(s):
Keywords(s): ALL - Acute Lymphoblastic Leukemia, Cancer/Oncology, Leukemia, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Therapy for T-Cell Lymphoma
NU2022-104
INVENTORS
Jaehyuk Choi*
Jay Daniels
Jurgen Ruland
Tim Wartweig
SHORT DESCRIPTION
Targeting PD-1 related mechanisms for treatment of aggressive T-Cell lymphomas
BACKGROUND
T-cell non-Hodgkin lymphomas (T-NHLs) are highly aggressive cancers that can be resistant to chemotherapies. The molecular pathogenesis of these cancers remains...
Published: 12/15/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Lymphoma, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Compounds and methods of identifying novel E3 ligases for targeted protein degradation
NU 2023-096
INVENTORS
Ananya Angela Basu
Xiaoyu Zhang*
SHORT DESCRIPTION
A CRISPR-activation screen for discovering E3 ligases amenable to targeted protein degradation, and a novel PROTAC for FBXO22
BACKGROUND
Traditional small molecule drugs function by directly interfering with the activities of proteins. However, many proteins lack suitable...
Published: 2/6/2026
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Inventor(s):
Keywords(s): AUTM26_1, Drug discovery, Proteomics, Small molecule
Category(s): Life Sciences > Therapeutics
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