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Biomimetic HDL Nanoparticles for Treatment of Cancer, Immune and Inflammatory Disorders, and Cardiovascular Disease
SHORT DESCRIPTION
Self-assembling biomimetic high-density lipoprotein nanoparticle (HDL NP) platform technology with a soft organic core, designed to more closely replicate key functional properties of mature human HDL for therapeutic use in cardiovascular disease, cancer, and inflammatory/immune disorders.
INVENTORS
Colby Thaxton*
Northwestern...
Published: 7/1/2026
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Updated: 6/16/2026
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Inventor(s):
Keywords(s): Atherosclerosis, Autoimmune disease, BIO2026, Breast cancer, Cancer/Oncology, Cardiology and Cardiovascular disease, Gene therapy, Immunology, Immunotherapy, Inflammation, Nanomaterials, Nanoparticle, Nanotechnology, Nucleic Acids, Platform technology, Prostate cancer, Research tool, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
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Assembly of Vaccines Using Cell-Free Integration of Viral Membrane Proteins into Liposomes
SHORT DESCRIPTION
A cell-free method that assembles vaccines by integrating viral membrane proteins into liposomes, enabling rapid prototype production without cold chain requirements.
INVENTORS
Neha Kamat*
McCormick School of Engineering, Department of Biomedical Engineering
Hector Aguilar-Carreno
Susan...
Published: 6/16/2026
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Updated: 6/10/2026
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Inventor(s):
Keywords(s): BIO2026, Immunology, Infectious disease, Nanomaterials, Nanoparticle, Nanotechnology, Synthetic biology, Vaccine
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Northwestern Startup: NanoIntegris, Inc. (Acquired by Raymor Industries)
Founded: 2006
Northwestern Inventor:
Mark Hersam
McCormick School of Engineering and Applied Science
Department of Material Science and Engineering
NanoIntegris is a leading supplier of premium single- and double-walled carbon nanotubes (SWNT, DWNT). The technology separates nano-tubes by diameter and/or electronic type (i.e., metal vs. semiconductor)....
Published: 6/22/2026
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Updated: 5/5/2026
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Inventor(s):
Keywords(s): Carbon nanotube, Graphene, Nanomaterials, Nanotechnology, Semiconductors & Integrated Circuits, Startup with Northwestern IP
Category(s): Physical Sciences > Materials and Industrial Processes
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Targeted Nanofiber Therapy for Atherosclerosis – Enhanced Plaque Regression via Precise Drug Delivery
SHORT DESCRIPTION
Nanofiber-based drug delivery system that targets atherosclerotic plaque and delivers a therapeutic agent locally to induce plaque regression for management of cardiovascular disease.
INVENTORS
Samuel Stupp*
Weinberg College of Arts and Sciences, Department of Chemistry
* Principal Investigator
NU...
Published: 6/16/2026
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Updated: 4/30/2026
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Inventor(s):
Keywords(s): Atherosclerosis, BIO2026, Biomaterials, Cardiology and Cardiovascular disease, Drug delivery, Nanomaterials, Nanotechnology, Self-assembly, Smart/Functional materials, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Bi-specific Lipid Nanoparticles for Boosting Antitumor Immunity in Glioblastoma
SHORT DESCRIPTION
A bispecific lipid nanoparticle that bridges tumor-associated myeloid cells (TAMCs) and glioma cells by dual checkpoint blockade and simultaneously reprograms TAMCs into antitumor effectors via targeted delivery of a STING agonist.
INVENTORS
Maciej Lesniak*
Northwestern University Feinberg School of Medicine,...
Published: 6/16/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): BIO2026, Brain cancer, Cancer/Oncology, Drug delivery, Immunotherapy, Nanoparticle, Nanotechnology, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Netrin-1 Mimetic Peptide Amphiphile Assemblies for Enhanced CNS Regeneration
NU 2024-174
INVENTORS
Samuel Stupp*
Cara Smith
Zaida Alvarez Pinto
SHORT DESCRIPTION
Nanofiber-shaped supramolecular assemblies that mimic netrin-1 bioactivity to stimulate neurite growth and synaptic maturation for enhanced CNS regeneration.
BACKGROUND
Neurotrophic factors are essential for the development and regeneration of neurons; however,...
Published: 6/16/2026
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Updated: 2/20/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, BIO2026, CNS - Central Nervous System, CVA - Cerebrovascular Accident, Nanomaterials, Nanotechnology, Neurodegenerative disease, Regenerative medicine, SCI - Spinal cord injury, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Projected Beam Pen Lithography for Benchtop High Resolution Maskless Photolithography of Large Areas
NU 2012-090
INVENTORS
Chad Mirkin (Northwestern University, Department of Chemistry)*
Keith Brown
Shu He
Guoliang Liu
Xing Liao
Wooyoung Shim
Abrin Schmucker
SHORT DESCRIPTION
This lithography system uses a projected beam pen method to directly pattern surfaces. It produces sub-100nm features quickly without the need for expensive masks.
BACKGROUND
Current...
Published: 12/9/2025
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Updated: 11/11/2025
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Inventor(s):
Keywords(s): Lithography, Nanomaterials, Nanotechnology, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169
INVENTORS
Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN))
Brian Meckes
Wuliang Zhang
SHORT DESCRIPTION
For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 12/9/2025
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Updated: 10/30/2025
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Inventor(s):
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
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Video-Rate Infrared Focal Plane Array Based on Solution-Processed Black Phosphorus Films
NU 2025-012
INVENTORS
Hooman Mohseni*
Mark Hersam*
Simone Bianconi
Vinod Sangwan
SHORT DESCRIPTION
This innovation demonstrates a video-rate infrared focal plane array fabricated by integrating solution-processed black phosphorus films with modified CMOS read-out integrated circuits, enabling high-performance mid-infrared imaging.
BACKGROUND
Conventional...
Published: 3/17/2026
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Updated: 10/17/2025
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Inventor(s):
Keywords(s): Nanomaterials, Nanotechnology
Category(s): Physical Sciences > Engineering & Technology, Physical Sciences > Materials and Industrial Processes
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Electrical Energy Generation Using Metal Nanofilms
NU 2014-102, 2018-154, 2019-155Primary InventorsFranz Geiger*Tom Miller* (CalTech)Short DescriptionMetal nanofilms that convert gravitational energy to electrical energy when aqueous drops roll down their surface.BackgroundHarvesting electrical energy from natural resources is critical to limit the consumption of batteries and fossil fuels. Approaches...
Published: 11/6/2025
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Updated: 5/16/2025
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Inventor(s):
Keywords(s): Cleantech, Energy and Infrastructure, Engineering, Nanotechnology, Novel Energy, Sensors, Thin film
Category(s): Physical Sciences > Energy & Sustainability
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