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Novel Methods to Upcycle Wear-Resistance Nanocomposites
NU 2020-149
INVENTORS
John Torkelson*
Tong Wei
ABSTRACT
Low density polyethylene (LDPE) is one of the most produced and consumed polymers worldwide. However, due to the poor wear and abrasion resistance, the application of LDPE under continuous friction is limited. This Northwestern technology improves the wear resistance of LDPE by incorporating...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Adhesive, Allergy, Analysis, Animal Model, Manufacturing/Processing
Category(s): Physical Sciences > Materials and Industrial Processes
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Modular Extracellular Sensors for Cell-based Biosensors
NU 2011-109BInventorsJoshua Leonard*Rachel Dudek Nichole Daringer Short DescriptionEngineered receptors designed to control gene expression BackgroundEngineering mammalian cell-based devices that monitor and therapeutically modulate human physiology is a promising and emerging frontier in clinical synthetic biology. However, realizing this vision required...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Animal Model, Diagnostics, Research tool, Sensors, Synthetic biology, Therapeutics
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Transgenic Mouse Model Exhibiting Physiological and Behavioral Defects due to Disruption in Circadian Rhythm
NU 1994-026InventorsJoseph TakahashiLawrence PintoFred Turek*William DoveAbstractNorthwestern researchers have a well-developed transgenic mouse model containing a clock defective gene. Based on their previous work, they had identified the clock gene as a regulator of machinery controlling the biological clock. They found that the clock defective mice...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Animal Model, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Reporter Mice for Tissue and Cell-Based Measurements of Circadian Rhythms
NU 2008-105 InventorsSeung-Hee Yoo Joseph S. Takahashi* AbstractCircadian rhythms are a popular area of research, and a number of proteins involved in the process have already been identified 'Äì including the PERIOD2 protein. Northwestern investigators have developed a mouse strain expressing a luciferase reporter gene fused to the C-terminus...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Animal Model, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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A Mouse Model to Visualize Motor Neurons
NU 2012-053 Inventor Pembe Hande Ozlinder AbstractNorthwestern researchers have developed a novel mice model that enables the visualization of both corticospinal and spinal motor neurons. In addition to enabling the in vivo visualization of these neurons at different stages of motor neuron disorders, this method also provides the capability to isolate...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Animal Model, Cell Line, Drug discovery, Neurology, Research reagent
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Mouse Model for Endocrine Pancreatic Development, Insulin Secretion and Diabetes
NU 2010-071InventorsJoseph Bass*Biliana MarchevaShort DescriptionA mouse model based on removing the clock function within islet cellsAbstractNorthwestern researchers created a mouse model based on removing the clock function within islet cells. These mice exhibit striking defects in insulin secretion which ultimately leads to greatly accelerated early...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Animal Model, Diabetes, Drug discovery, Research tool, Stem cell
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Transgenic Mouse Model of Fibrodisplasia Ossificans Progressiva (FOP)
NU 2007-076 Inventor John A. Kessler Short DescriptionNew mouse model of FOP, a rare genetic disease characterized by abnormal growth of bone which replaces soft tissues AbstractNorthwestern University scientists developed a mouse model of fibrodisplasia ossificans progressiva (FOP), a rare genetic disease that causes soft tissues to be replaced with...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Animal Model, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Transgenic Mouse Model of Amyloid Pathogenesis
NU 2009-195 Inventors John Csernansky* Hongxin Dong Louis Muglia Short Description Mouse model for directly testing the involvement of stress in Alzheimer's disease progress Abstract Northwestern researchers have engineered a triple transgenic mouse that can be used to investigate the contribution of stress to development of Alzheimer's Disease...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Animal Model, Neurodegenerative disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Knock Out Mouse Model of Cognitive Deficits
NU 2007-037 InventorsPeter Penzes* Short DescriptionMouse model of cognitive deficits associated with aberrant formation of neural synapses AbstractA Northwestern researcher has developed a mouse model that approximates human cognitive deficits. Neurodevelopmental and neuropsychiatric disorders that affect cognition are devastating illnesses that impose...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Animal Model, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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An Animal Model for Uterine Fibroid Embolization
NU 2006-021 InventorsReed Omary Robert Ryu AbstractNorthwestern investigators have created an animal model platform that successfully induces the formation of fibroids in the rabbit uterus. They are able to use MRI to detect acute perfusion changes in this model following uterine artery embolization (UAE). Such an animal model would be desirable for...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Animal Model, Obstetric/Gynecological, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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