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Potent and selective Cav1.3 negative allosteric modulators for use in Parkinson's Disease
NU 2010-105 and NU 2024-179
INVENTORS
Richard Silverman* (Northwestern University, Weinberg College of Arts & Science, Department of Chemistry)
Dalton Surmeier Jr.* (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience)
Garry Cooper
Soosung Kang
Jack Nguyen
SHORT DESCRIPTION
For pharmaceutical...
Published: 11/11/2025
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Inventor(s):
Keywords(s): Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
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A Novel Combination Therapy for Parkinson’s Disease
NU 2013-149
INVENTORS
Dalton Surmeier Jr. (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience)*
Daniel Galtieri
Ema Ilijic
Enrico Zampese
Jaime Guzman-Lucero
Javier Sanchez
SHORT DESCRIPTION
This technology uses a low-dose combination of two FDA-approved compounds to reduce oxidative stress in neurons...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biomedical, Drug delivery, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Cell-type specific disruption of M1 muscarinic acetylcholine receptor expression to alleviate Parkinson's disease
NU 2024-244
INVENTORS
Dalton J. Surmeier Jr*
Tatiana Tkatch
Shenyu Zhai
SHORT DESCRIPTION
Gene therapy targeting M1 muscarinic receptor expression in striatal spiny projection neurons to enhance levodopa response and slow Parkinson’s Disease progression.
BACKGROUND
Parkinson’s Disease (PD) is the second most common age-related...
Published: 11/6/2025
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Inventor(s):
Keywords(s): CNS - Central Nervous System, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
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Gene therapy for levodopa-induced dyskinesia
NU 2024-086
INVENTORS
Dalton J. Surmeier Jr*
Weixing Shen
Shenyu Zhai
Tatiana Tkatch
Qiaoling Cui
Zhong Xie
SHORT DESCRIPTION
Gene therapy targeting GRIN2B in striatal spiny projection neurons to treat levodopa-induced dyskinesia.
BACKGROUND
Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease...
Published: 11/6/2025
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Inventor(s):
Keywords(s): CNS - Central Nervous System, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
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Therapeutic Intervention for ALS and Dementia
NU 2021-058
INVENTORS
Evangelos Kiskinis*
Juan Alberto Ortega Cano Marco Boccitto
SHORT DESCRIPTION
Design of an RNA-based oligonucleotide that protects from dipeptide repeat protein toxicity for the treatment of ALS and FTD.
BACKGROUND
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative diseases...
Published: 11/6/2025
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Inventor(s):
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, CNS - Central Nervous System, DPR - Dipeptide Repeat Proteins, FTD - Frontotemporal Dementia, Neurodegenerative disease, Neurology, RNA - Ribonucleic Acid, Therapeutics
Category(s): Life Sciences > Therapeutics
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A peptidomimetic for LIMP-2 based activation of Glucocerebrosidase as a Gaucher/Parkinson’s Disease therapeutic
NU 2016-019
INVENTORS
Dimitri Krainc*
Michael Schwake
SHORT DESCRIPTION
LIMP-2-based peptidomimetic compounds to facilitate glucocerebrosidase activation in Gaucher and Parkinson’s Disease
BACKGROUND
Mutations in glucocerebrosidase (GCase) cause Gaucher Disease. Additionally, GCase mutations are a major risk factor in Parkinson’s Disease,...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Pharmacotherapy for Preventing Neurodegeneration
NU 2016-108
INVENTORS
D. James Surmeier*
Steven M. Graves
SHORT DESCRIPTION
Small molecule therapeutics to prevent neurological degeneration associated with other pharmaceutical treatments
ABSTRACT
Methamphetamine and amphetamine are pharmaceutical drugs sometimes used to treat attention definicity hyperactive disorder (ADHD), obesity, and narcolepsy....
Published: 11/6/2025
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Inventor(s):
Keywords(s): Neurodegenerative disease, Neurologic disease, Obesity, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Gene Therapy for Parkinson's Disease
NU 2021-039
INVENTORS
D. James Surmeier*
Michael Kaplitt
Patricia Gonzalez Rodriguez
SHORT DESCRIPTION
A simple neurological procedure to treat late-stage Parkinson’s Disease patients
BACKGROUND
Approximately 60,000 Americans are diagnosed with Parkinson’s Disease (PD) each year. Although levodopa has been the gold-standard for symptomatic...
Published: 11/6/2025
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Inventor(s):
Keywords(s): CNS - Central Nervous System, Gene therapy, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Combination Treatment to Reduce Pathological Proteins in Neurodegenerative and Lysosomal Storage Diseases
NU 2021-206
INVENTORS
Joseph Mazzulli*
Iva Stojkovska
SHORT DESCRIPTION
A small molecule combination treatment to improve lysosomal function in neurodegenerative and lysosomal storage diseases
BACKGROUND
Many neurodegenerative disorders are characterized by a collapse in proteostasis, as shown by the accumulation of insoluble protein aggregates...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Biomedical, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Small molecule
Category(s): Life Sciences > Therapeutics
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Nanostructures for Diagnosis and Therapy of Alzheimer's Disease
NU 2009-169 Inventors Vinayak Dravid* Saurabh Sharma Kristen Viola William Klein* Short Description Novel magnetic nanostructures that recognize toxic beta-amyloid protein oligomers responsible for Alzheimer's disease progression Abstract Northwestern University researchers have developed a new magnetic nanostructure that can be used to detect and...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Biomarker, Devices, Diagnostics, Health IT, Medical device, Nanoparticle, Neurodegenerative disease, Neurologic disease, Research tool, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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