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Epigenetic Gene Editing in Cardiomyopathy to Improve Heart Function
SHORT DESCRIPTION
A precision cardiac gene‑regulation platform that deletes a MYH7 enhancer to shift ventricular myosin isoform balance toward faster α‑MHC and activates upstream MYH6 enhancers to increase MYH6 expression and improve contractility, creating a dual toolkit for disease‑modifying therapy in cardiomyopathy and heart failure.
INVENTORS
Elizabeth...
Published: 5/15/2026
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Updated: 5/12/2026
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Cardiomyopathy, Gene therapy, Regenerative medicine, Therapeutics
Category(s): Life Sciences > Therapeutics
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Targeted Nanofiber Therapy for Atherosclerosis – Enhanced Plaque Regression via Precise Drug Delivery
SHORT DESCRIPTION
Nanofiber-based drug delivery system that targets atherosclerotic plaque and delivers a therapeutic agent locally to induce plaque regression for management of cardiovascular disease.
INVENTORS
Samuel Stupp*
Weinberg College of Arts and Sciences, Department of Chemistry
* Principal Investigator
NU...
Published: 4/30/2026
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Updated: 4/30/2026
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Precision Gene Therapy for Diseases Driven by Endothelial Dysfunction
SHORT DESCRIPTION
Dual promoter system constructs for tissue-specific and cell-type-specific gene expression, enabling precision gene therapy targeting endothelial dysfunction in specific organs.
INVENTORS
Youyang Zhao*
Ann & Robert H Lurie Children's Hospital of Chicago
* Principal Investigator
NU...
Published: 5/8/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, CMD - Cardiometabolic disease, CPD - Cardiopulmonary disease, Gene therapy, Pulmonary disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease
Category(s): Life Sciences > Therapeutics
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Retinoic Acid Agonists for Attenuation of Doxorubicin-Induced Cardiotoxicity
SHORT DESCRIPTION
A method for preventing cardiotoxicity in patients undergoing anthracycline-based chemotherapy using retinoic acid receptor gamma (RARG) agonists.
INVENTORS
Paul W Burridge*, PhD
Associate Professor, Pharmacology, Northwestern University Feinberg School of Medicine
* Principal Investigator
NU...
Published: 2/6/2026
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Updated: 2/6/2026
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Inventor(s):
Keywords(s): Cancer Treatment, Cancer/Oncology, Cardiology and Cardiovascular disease, Chemotherapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Identification of Atrial Fibrillation Progression via Integrated Electrogram and Imaging Analysis
NU 2023-222
INVENTORS
Markus Rottmann*
SHORT DESCRIPTION
This invention integrates advanced analysis of atrial fibrillation electrograms and T1/T2 imaging to identify the progression state of AF. It offers clinicians a predictive tool to tailor treatment strategies and improve patient management.
BACKGROUND
Atrial fibrillation shows distinct...
Published: 12/9/2025
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Updated: 10/28/2025
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
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Morphology Recurrence Analysis for the Characterization of Atrial Fibrillation Electrograms
INVENTORS
Jeffrey Goldberger*
David Gordon
Jason Ng
SHORT DESCRIPTION
This technique uses modified recurrence analysis on electrogram data to identify patient-specific arrhythmia drivers. It supports precise, tailored ablation mapping for atrial fibrillation.
BACKGROUND
Traditional atrial fibrillation mapping struggles with dynamic, variable...
Published: 12/9/2025
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Updated: 10/21/2025
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Inventor(s):
Keywords(s): Analysis, Biomedical, Cardiology and Cardiovascular disease, Computer software, Devices, Electrophysiology, Health IT, Medical device
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Automated Echocardiographic Detection of Cardiac Amyloidosis: The Septal Reflectivity Ratio
NU2023-056
INVENTORS
Sanjiv Shah*
Vinesh Appadurai
Mayank Kansal
Akhil Narang
Brody Slostad
James Thomas
SHORT DESCRIPTION
A first-of-its-kind diagnostic tool that automates the analysis of echocardiographic images to calculate the septal reflectivity ratio, enabling precise differentiation between cardiac amyloidosis subtypes.
BACKGROUND
Conventional...
Published: 11/6/2025
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Updated: 6/18/2025
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Inventor(s): Mayank Kansal
Keywords(s): Cardiology and Cardiovascular disease
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Transparent Arterial Layer Separation in Cardiac Angiography with Self-Supervised Deep Learning
NU 2023-092
INVENTORS
Sameer Ansari*
Donald Cantrell*
Leon Cho
Syed Hasib Akhter Faruqui
Chaochao Zhou
SHORT DESCRIPTION
This technology provides cardiac angiography with markedly enhanced visualization of the vasculature by leveraging self-supervised deep neural network-based background subtraction algorithms.
BACKGROUND
Cardiac angiography relies...
Published: 11/6/2025
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Updated: 5/12/2025
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Image/Signal processing
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Wireless, Implantable Catheter-type Oximeter Designed for Cardiac Oxygen Saturation
LUNU 2020-226
INVENTORS
John Rogers*
Wei Lu
Joseph Forbess
Zhi-Dong Ge
SHORT DESCRIPTION
This technology introduces a wireless, miniaturized, implantable catheter-type oximeter designed to offer real-time monitoring of intravascular oxygen levels for post-cardiothoracic surgery care.
BACKGROUND
Accurate, real-time monitoring of intravascular oxygen...
Published: 11/6/2025
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Updated: 5/7/2025
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Inventor(s):
Keywords(s): Biomedical, Cardiology and Cardiovascular disease, Devices, Diagnostics, Medical device, Optics, Sensors, Wireless
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Small molecule inhibits the interaction between tristetraprolin and CNOT1 for therapeutic use in metabolic disorders
NU 2024-057
INVENTORS
Hossein Ardehali*
Jason Shapiro
SHORT DESCRIPTION
Compound that inhibits the interaction between tristetraprolin (TTP) and CCR4-NOT Transcription Complex Subunit 1 (CNOT1) offers potential therapeutic avenue for metabolic disorders by modulating mRNA degradation without inflammatory side effects.
BACKGROUND
Metabolic disorders...
Published: 3/26/2026
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Updated: 5/5/2025
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Diabetes, Metabolic disorders, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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