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Precision Gene Therapy for Diseases Driven by Endothelial Dysfunction
SHORT DESCRIPTION
Dual promoter system constructs for tissue-specific and cell-type-specific gene expression, enabling precision gene therapy targeting endothelial dysfunction in specific organs.
INVENTORS
Youyang Zhao*
Ann & Robert H Lurie Children's Hospital of Chicago
* Principal Investigator
NU...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, CMD - Cardiometabolic disease, CPD - Cardiopulmonary disease, Gene therapy, Pulmonary disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease
Category(s): Life Sciences > Therapeutics
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Neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and neurodegenerative disorders
NU 2025-113 (NU 2016-137, NU 2018-176, NU 2019-179, NU 2023-007, NU 2024-250, NU 2025-038)
INVENTORS
Richard Silverman
Weinberg College of Arts and Sciences, Department of Chemistry
SHORT DESCRIPTION
Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and other cancers with high expression...
Published: 4/22/2026
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Updated: 4/1/2026
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Inventor(s):
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, AUTM26C1, BIAUTM1, Cancer/Oncology, Cardiology and Cardiovascular disease, Immunodeficiency, Immunology, Immunotherapy, Melanoma, Neurodegenerative disease, Neuroinflammation, nNOS, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Retinoic Acid Agonists for Attenuation of Doxorubicin-Induced Cardiotoxicity
SHORT DESCRIPTION
A method for preventing cardiotoxicity in patients undergoing anthracycline-based chemotherapy using retinoic acid receptor gamma (RARG) agonists.
INVENTORS
Paul W Burridge*, PhD
Associate Professor, Pharmacology, Northwestern University Feinberg School of Medicine
* Principal Investigator
NU...
Published: 2/6/2026
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Updated: 2/6/2026
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Inventor(s):
Keywords(s): Cancer Treatment, Cancer/Oncology, Cardiology and Cardiovascular disease, Chemotherapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Identification of Atrial Fibrillation Progression via Integrated Electrogram and Imaging Analysis
NU 2023-222
INVENTORS
Markus Rottmann*
SHORT DESCRIPTION
This invention integrates advanced analysis of atrial fibrillation electrograms and T1/T2 imaging to identify the progression state of AF. It offers clinicians a predictive tool to tailor treatment strategies and improve patient management.
BACKGROUND
Atrial fibrillation shows distinct...
Published: 12/9/2025
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Updated: 10/28/2025
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
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Morphology Recurrence Analysis for the Characterization of Atrial Fibrillation Electrograms
INVENTORS
Jeffrey Goldberger*
David Gordon
Jason Ng
SHORT DESCRIPTION
This technique uses modified recurrence analysis on electrogram data to identify patient-specific arrhythmia drivers. It supports precise, tailored ablation mapping for atrial fibrillation.
BACKGROUND
Traditional atrial fibrillation mapping struggles with dynamic, variable...
Published: 12/9/2025
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Updated: 10/21/2025
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Inventor(s):
Keywords(s): Analysis, Biomedical, Cardiology and Cardiovascular disease, Computer software, Devices, Electrophysiology, Health IT, Medical device
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Automated Echocardiographic Detection of Cardiac Amyloidosis: The Septal Reflectivity Ratio
NU2023-056
INVENTORS
Sanjiv Shah*
Vinesh Appadurai
Mayank Kansal
Akhil Narang
Brody Slostad
James Thomas
SHORT DESCRIPTION
A first-of-its-kind diagnostic tool that automates the analysis of echocardiographic images to calculate the septal reflectivity ratio, enabling precise differentiation between cardiac amyloidosis subtypes.
BACKGROUND
Conventional...
Published: 11/6/2025
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Updated: 6/18/2025
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Inventor(s): Mayank Kansal
Keywords(s): Cardiology and Cardiovascular disease
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Transparent Arterial Layer Separation in Cardiac Angiography with Self-Supervised Deep Learning
NU 2023-092
INVENTORS
Sameer Ansari*
Donald Cantrell*
Leon Cho
Syed Hasib Akhter Faruqui
Chaochao Zhou
SHORT DESCRIPTION
This technology provides cardiac angiography with markedly enhanced visualization of the vasculature by leveraging self-supervised deep neural network-based background subtraction algorithms.
BACKGROUND
Cardiac angiography relies...
Published: 11/6/2025
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Updated: 5/12/2025
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Image/Signal processing
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Wireless, Implantable Catheter-type Oximeter Designed for Cardiac Oxygen Saturation
LUNU 2020-226
INVENTORS
John Rogers*
Wei Lu
Joseph Forbess
Zhi-Dong Ge
SHORT DESCRIPTION
This technology introduces a wireless, miniaturized, implantable catheter-type oximeter designed to offer real-time monitoring of intravascular oxygen levels for post-cardiothoracic surgery care.
BACKGROUND
Accurate, real-time monitoring of intravascular oxygen...
Published: 11/6/2025
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Updated: 5/7/2025
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Inventor(s):
Keywords(s): Biomedical, Cardiology and Cardiovascular disease, Devices, Diagnostics, Medical device, Optics, Sensors, Wireless
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Small molecule inhibits the interaction between tristetraprolin and CNOT1 for therapeutic use in metabolic disorders
NU 2024-057
INVENTORS
Hossein Ardehali*
Jason Shapiro
SHORT DESCRIPTION
Compound that inhibits the interaction between tristetraprolin (TTP) and CCR4-NOT Transcription Complex Subunit 1 (CNOT1) offers potential therapeutic avenue for metabolic disorders by modulating mRNA degradation without inflammatory side effects.
BACKGROUND
Metabolic disorders...
Published: 3/26/2026
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Updated: 5/5/2025
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Diabetes, Metabolic disorders, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Personalized chest acceleration derived prediction of cardiovascular abnormalities using deep learning
Personalized chest acceleration derived prediction of cardiovascular abnormailities using deep learning
NU 2023-121
INVENTORS
Michael Markl *
Ethan M.I. Johnson
Mahmoud Ebrahimkhani
SHORT DESCRIPTION
A system and method for predicting cardiovascular function using machine learning from physiological patient data.
BACKGROUND
Cardiac and flow...
Published: 11/6/2025
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Updated: 4/22/2025
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Inventor(s):
Keywords(s): Artificial Intelligence & Machine Learning, Cardiology and Cardiovascular disease, Cardio-Pulmonary, Computer hardware, Devices, Diagnostics, Imaging, Mobile networking, Networking
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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