|
Compositions and Methods for Enhanced Mitochondrial Delivery for Regenerative Therapies
SHORT DESCRIPTION
A novel peptide coating process that improves mitochondrial cell uptake, preserves function, and enables targeted delivery for cardiovascular and regenerative therapies.
NU Tech ID
NU 2025-055
INVENTORS
Bin Jiang*
Northwestern University Feinberg School of Medicine, Department of Surgery (Vascular...
Published: 6/18/2026
|
Updated: 6/18/2026
|
Inventor(s):
Keywords(s): BIO2026, Cardiology and Cardiovascular disease, MI - Myocardial Infarction, Neurodegenerative disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease, Vascular repair
Category(s): Life Sciences > Therapeutics
|
|
FTY720 for Treatment of Marfan Syndrome
NU2025-219
INVENTORS
Tsutomu Kume*
Can Tan
SHORT DESCRIPTION
This invention provides a novel use for FTY720, also known as Fingolimod, for the treatment and prevention of myxomatous degeneration of the mitral valve (MDMV) in Marfan syndrome.
BACKGROUND
Marfan syndrome, a genetic connective tissue disorder, frequently leads to MDMV, a severe...
Published: 6/18/2026
|
Updated: 6/18/2026
|
Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Repurposed Drugs, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Biomimetic HDL Nanoparticles for Treatment of Cancer, Immune and Inflammatory Disorders, and Cardiovascular Disease
SHORT DESCRIPTION
Self-assembling biomimetic high-density lipoprotein nanoparticle (HDL NP) platform technology with a soft organic core, designed to more closely replicate key functional properties of mature human HDL for therapeutic use in cardiovascular disease, cancer, and inflammatory/immune disorders.
INVENTORS
Colby Thaxton*
Northwestern...
Published: 7/1/2026
|
Updated: 6/16/2026
|
Inventor(s):
Keywords(s): Atherosclerosis, Autoimmune disease, BIO2026, Breast cancer, Cancer/Oncology, Cardiology and Cardiovascular disease, Gene therapy, Immunology, Immunotherapy, Inflammation, Nanomaterials, Nanoparticle, Nanotechnology, Nucleic Acids, Platform technology, Prostate cancer, Research tool, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
|
|
Epigenetic Gene Editing in Cardiomyopathy to Improve Heart Function
SHORT DESCRIPTION
A precision cardiac gene‑regulation platform that deletes a MYH7 enhancer to shift ventricular myosin isoform balance toward faster α‑MHC and activates upstream MYH6 enhancers to increase MYH6 expression and improve contractility, creating a dual toolkit for disease‑modifying therapy in cardiomyopathy and heart failure.
INVENTORS
Elizabeth...
Published: 6/16/2026
|
Updated: 5/12/2026
|
Inventor(s):
Keywords(s): BIO2026, Cardiology and Cardiovascular disease, Cardiomyopathy, Gene therapy, Regenerative medicine, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Targeted Nanofiber Therapy for Atherosclerosis – Enhanced Plaque Regression via Precise Drug Delivery
SHORT DESCRIPTION
Nanofiber-based drug delivery system that targets atherosclerotic plaque and delivers a therapeutic agent locally to induce plaque regression for management of cardiovascular disease.
INVENTORS
Samuel Stupp*
Weinberg College of Arts and Sciences, Department of Chemistry
* Principal Investigator
NU...
Published: 6/16/2026
|
Updated: 4/30/2026
|
Inventor(s):
Keywords(s): Atherosclerosis, BIO2026, Biomaterials, Cardiology and Cardiovascular disease, Drug delivery, Nanomaterials, Nanotechnology, Self-assembly, Smart/Functional materials, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Precision Gene Therapy for Diseases Driven by Endothelial Dysfunction
SHORT DESCRIPTION
Dual promoter system constructs for tissue-specific and cell-type-specific gene expression, enabling precision gene therapy targeting endothelial dysfunction in specific organs.
INVENTORS
Youyang Zhao*
Ann & Robert H Lurie Children's Hospital of Chicago
* Principal Investigator
NU...
Published: 6/16/2026
|
Updated: 4/27/2026
|
Inventor(s):
Keywords(s): BIO2026, Cardiology and Cardiovascular disease, CMD - Cardiometabolic disease, CPD - Cardiopulmonary disease, Gene therapy, Pulmonary disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease
Category(s): Life Sciences > Therapeutics
|
|
Retinoic Acid Agonists for Attenuation of Doxorubicin-Induced Cardiotoxicity
SHORT DESCRIPTION
A method for preventing cardiotoxicity in patients undergoing anthracycline-based chemotherapy using retinoic acid receptor gamma (RARG) agonists.
INVENTORS
Paul W Burridge*, PhD
Associate Professor, Pharmacology, Northwestern University Feinberg School of Medicine
* Principal Investigator
NU...
Published: 2/6/2026
|
Updated: 2/6/2026
|
Inventor(s):
Keywords(s): Cancer Treatment, Cancer/Oncology, Cardiology and Cardiovascular disease, Chemotherapy, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Identification of Atrial Fibrillation Progression via Integrated Electrogram and Imaging Analysis
NU 2023-222
INVENTORS
Markus Rottmann*
SHORT DESCRIPTION
This invention integrates advanced analysis of atrial fibrillation electrograms and T1/T2 imaging to identify the progression state of AF. It offers clinicians a predictive tool to tailor treatment strategies and improve patient management.
BACKGROUND
Atrial fibrillation shows distinct...
Published: 12/9/2025
|
Updated: 10/28/2025
|
Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
|
|
Morphology Recurrence Analysis for the Characterization of Atrial Fibrillation Electrograms
INVENTORS
Jeffrey Goldberger*
David Gordon
Jason Ng
SHORT DESCRIPTION
This technique uses modified recurrence analysis on electrogram data to identify patient-specific arrhythmia drivers. It supports precise, tailored ablation mapping for atrial fibrillation.
BACKGROUND
Traditional atrial fibrillation mapping struggles with dynamic, variable...
Published: 12/9/2025
|
Updated: 10/21/2025
|
Inventor(s):
Keywords(s): Analysis, Biomedical, Cardiology and Cardiovascular disease, Computer software, Devices, Electrophysiology, Health IT, Medical device
Category(s): Life Sciences > Healthcare Devices, Tools & IT
|
|
Automated Echocardiographic Detection of Cardiac Amyloidosis: The Septal Reflectivity Ratio
NU2023-056
INVENTORS
Sanjiv Shah*
Vinesh Appadurai
Mayank Kansal
Akhil Narang
Brody Slostad
James Thomas
SHORT DESCRIPTION
A first-of-its-kind diagnostic tool that automates the analysis of echocardiographic images to calculate the septal reflectivity ratio, enabling precise differentiation between cardiac amyloidosis subtypes.
BACKGROUND
Conventional...
Published: 11/6/2025
|
Updated: 6/18/2025
|
Inventor(s): Mayank Kansal
Keywords(s): Cardiology and Cardiovascular disease
Category(s): Life Sciences > Healthcare Devices, Tools & IT
|