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Targeted Nanoparticle-Mediated HIF Stabilization in Myeloid Cells for Enhanced Transplant Tolerance
SHORT DESCRIPTION
A PEG-PPS nanoparticle technology for targeted delivery of roxadustat to myeloid cells to promote transplantation tolerance.
INVENTORS
Edward Thorp*
Northwestern University Feinberg School of Medicine, Department of Pathology
Evan Scott*
McCormick School of Engineering, Department...
Published: 5/7/2026
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Updated: 5/7/2026
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Inventor(s):
Keywords(s): Drug delivery, Immunotherapy, Nanoparticle, Therapeutics, Tolerance induction, Transplantation
Category(s): Life Sciences > Therapeutics
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Targeting Autoimmunity-Associated T cells via AHR Pathway Control
SHORT DESCRIPTION
Use of AHR agonists to inhibit pathogenic Tfh/Tph cell differentiation, potentially reducing disease activity.
INVENTORS
Jaehyuk Choi*
Northwestern University Feinberg School of Medicine, Department of Dermatology **(Now at UT Southwestern)**
Deepak Rao
Brigham and Women's...
Published: 5/7/2026
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Updated: 5/7/2026
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Inventor(s):
Keywords(s): Autoimmune disease, Immunology, Immunotherapy, Inflammation, RA - Rheumatoid arthritis, SLE - Systemic lupus erythematosus, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION
Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma.
INVENTORS
Amy Heimberger*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
* Principal Investigator
NU Tech ID: NU 2025-212
IP...
Published: 5/7/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Nano-therapeutics Targeting Cholesterol Efflux Transporter in Macrophages for Cancer Immunotherapy
NU 2025-160
INVENTORS
Jason Miska*
Feinberg School of Medicine, Department of Neurological Surgery
Peng Zhang*
Feinberg School of Medicine, Department of Neurological Surgery
SHORT DESCRIPTION
Novel nanoparticle technology that modulates macrophage cholesterol metabolism to boost anti-tumor immunity in GBM.
BACKGROUND
Glioblastoma...
Published: 4/16/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Adjunct therapy, Brain cancer, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunotherapy, Nanoparticle, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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SEC61 Complex as a Novel Therapeutic Target to Enhance Immunotherapy Response in Glioblastoma
NU 2023-011
INVENTORS
Irina Balyasnikova*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
Joseph Duffy
SHORT DESCRIPTION
A targeted therapeutic approach that inhibits the SEC61 complex to enhance responses to immunotherapy in glioblastoma.
BACKGROUND
Glioblastoma (GBM) is the most aggressive primary...
Published: 4/14/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Brain cancer, Cancer/Oncology, Immunotherapy, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Anti-TYRP1 Bi-specific T cell Engager for Treatment of TYRP1-expressing melanoma
NU 2022-123
INVENTORS
Irina Balyasnikova (Feinberg School of Medicine, Department of Neurological Surgery)*
Isabelle Le Poole (Feinberg School of Medicine, Department of Dermatology)*
SHORT DESCRIPTION
A bispecific T cell engager that targets CD3+ T cells and TYRP1-expressing melanoma cells.
BACKGROUND
Melanoma is the deadliest form of skin...
Published: 4/14/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Biologic, Cancer/Oncology, Immunotherapy, Melanoma, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Orthogonal Synthetic Receptors for IL-23
SHORT DESCRIPTION
Synthetic IL-23 receptors for cell engineering to enable real-time sensing and drive precise autoimmune and cancer immunotherapy interventions.
INVENTORS
Joshua Leonard*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Aaron Morris
William Corcoran
...
Published: 5/8/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Autoimmune disease, Cell engineering, Cell therapy, Diagnostics, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Responsive Probiotic Therapy for Local Detection and Treatment of IBD Flares
SHORT DESCRIPTION
An engineered probiotic that senses intestinal inflammation via calprotectin and locally releases therapeutic antibodies in the gastrointestinal tract only during inflammatory flares.
INVENTORS
Arthur Prindle*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Jonathan...
Published: 5/11/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Autoimmune disease, Biologic, Cell therapy, Diagnostics, Gastrointestinal and Hepatic disease, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Synthetic biology, Therapeutics
Category(s): Life Sciences > Therapeutics
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Bi-specific Lipid Nanoparticles for Boosting Antitumor Immunity in Glioblastoma
SHORT DESCRIPTION
A bispecific lipid nanoparticle that bridges tumor-associated myeloid cells (TAMCs) and glioma cells by dual checkpoint blockade and simultaneously reprograms TAMCs into antitumor effectors via targeted delivery of a STING agonist.
INVENTORS
Maciej Lesniak*
Northwestern University Feinberg School of Medicine,...
Published: 4/30/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Brain cancer, Cancer/Oncology, Drug delivery, Immunotherapy, Nanoparticle, Nanotechnology, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and neurodegenerative disorders
NU 2025-113 (NU 2016-137, NU 2018-176, NU 2019-179, NU 2023-007, NU 2024-250, NU 2025-038)
INVENTORS
Richard Silverman
Weinberg College of Arts and Sciences, Department of Chemistry
SHORT DESCRIPTION
Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and other cancers with high expression...
Published: 5/21/2026
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Updated: 4/1/2026
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Inventor(s):
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, AUTM26C1, BIAUTM1, Cancer/Oncology, Cardiology and Cardiovascular disease, Immunodeficiency, Immunology, Immunotherapy, Melanoma, Neurodegenerative disease, Neuroinflammation, nNOS, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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