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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION
Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma.
INVENTORS
Amy Heimberger*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
* Principal Investigator
NU Tech ID: NU 2025-212
IP...
Published: 5/7/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Covalent ATG4B Inhibitors for Treatment of Cancer
NU 2025-186
INVENTORS
Karl Scheidt*
Weinberg College of Arts and Sciences, Department of Chemistry
Claire Trudeau
Shiyuan Cheng
SHORT DESCRIPTION
The invention introduces a novel class of peptidyl covalent reversible ketoamide inhibitors designed to target the cysteine protease ATG4B.
BACKGROUND
Glioblastoma (GBM) is an aggressive...
Published: 5/13/2026
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Updated: 10/28/2025
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Inventor(s):
Keywords(s): Autophagy, Brain cancer, Cancer/Oncology, GBM - Glioblastoma, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Methods for Enhancing GBM Treatment Through Inhibition of Autophagy Mediator ATG4B
NU 2019-106
INVENTORS
Shi-Yuan Cheng*
Feinberg School of Medicine, Department of Neurology
Bo Hu
Tianzhi Huang
SHORT DESCRIPTION
A novel autophagy inhibitor to enhance the efficiency of standard cancer treatments
BACKGROUND
Glioblastoma (GBM), an incurable, lethal disease, exhibits a poor 5-year survival rate. The usual treatment...
Published: 5/13/2026
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Updated: 6/1/2023
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Inventor(s):
Keywords(s): Autophagy, Brain cancer, Cancer/Oncology, GBM - Glioblastoma, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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