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Potent and selective Cav1.3 negative allosteric modulators for use in Parkinson's Disease
NU 2010-105 and NU 2024-179
INVENTORS
Richard Silverman* (Northwestern University, Weinberg College of Arts & Science, Department of Chemistry)
Dalton Surmeier Jr.* (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience)
Garry Cooper
Soosung Kang
Jack Nguyen
SHORT DESCRIPTION
For pharmaceutical...
Published: 11/11/2025
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Inventor(s):
Keywords(s): Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
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A Novel Combination Therapy for Parkinson’s Disease
NU 2013-149
INVENTORS
Dalton Surmeier Jr. (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience)*
Daniel Galtieri
Ema Ilijic
Enrico Zampese
Jaime Guzman-Lucero
Javier Sanchez
SHORT DESCRIPTION
This technology uses a low-dose combination of two FDA-approved compounds to reduce oxidative stress in neurons...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biomedical, Drug delivery, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Cell-type specific disruption of M1 muscarinic acetylcholine receptor expression to alleviate Parkinson's disease
NU 2024-244
INVENTORS
Dalton J. Surmeier Jr*
Tatiana Tkatch
Shenyu Zhai
SHORT DESCRIPTION
Gene therapy targeting M1 muscarinic receptor expression in striatal spiny projection neurons to enhance levodopa response and slow Parkinson’s Disease progression.
BACKGROUND
Parkinson’s Disease (PD) is the second most common age-related...
Published: 11/6/2025
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Inventor(s):
Keywords(s): CNS - Central Nervous System, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
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Gene therapy for levodopa-induced dyskinesia
NU 2024-086
INVENTORS
Dalton J. Surmeier Jr*
Weixing Shen
Shenyu Zhai
Tatiana Tkatch
Qiaoling Cui
Zhong Xie
SHORT DESCRIPTION
Gene therapy targeting GRIN2B in striatal spiny projection neurons to treat levodopa-induced dyskinesia.
BACKGROUND
Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease...
Published: 11/6/2025
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Inventor(s):
Keywords(s): CNS - Central Nervous System, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
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A peptidomimetic for LIMP-2 based activation of Glucocerebrosidase as a Gaucher/Parkinson’s Disease therapeutic
NU 2016-019
INVENTORS
Dimitri Krainc*
Michael Schwake
SHORT DESCRIPTION
LIMP-2-based peptidomimetic compounds to facilitate glucocerebrosidase activation in Gaucher and Parkinson’s Disease
BACKGROUND
Mutations in glucocerebrosidase (GCase) cause Gaucher Disease. Additionally, GCase mutations are a major risk factor in Parkinson’s Disease,...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Gene Therapy for Parkinson's Disease
NU 2021-039
INVENTORS
D. James Surmeier*
Michael Kaplitt
Patricia Gonzalez Rodriguez
SHORT DESCRIPTION
A simple neurological procedure to treat late-stage Parkinson’s Disease patients
BACKGROUND
Approximately 60,000 Americans are diagnosed with Parkinson’s Disease (PD) each year. Although levodopa has been the gold-standard for symptomatic...
Published: 11/6/2025
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Inventor(s):
Keywords(s): CNS - Central Nervous System, Gene therapy, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Combination Treatment to Reduce Pathological Proteins in Neurodegenerative and Lysosomal Storage Diseases
NU 2021-206
INVENTORS
Joseph Mazzulli*
Iva Stojkovska
SHORT DESCRIPTION
A small molecule combination treatment to improve lysosomal function in neurodegenerative and lysosomal storage diseases
BACKGROUND
Many neurodegenerative disorders are characterized by a collapse in proteostasis, as shown by the accumulation of insoluble protein aggregates...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Biomedical, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Small molecule
Category(s): Life Sciences > Therapeutics
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Deep Learning Structural Analysis Of Cerebral Cortex Predicts Features From MRI Data
NU 2020-152
INVENTORS
Pierre Alain Besson
S. Kathleen Bandt*
SHORT DESCRIPTION
Graph convolutional neural networks (gCNNs) successfully predict patient age and sex from T1-weighted brain surface MRI data.
BACKGROUND
As clinical image-based data sets grow in resolution and size, the promise of machine learning greatly expedites image classification...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Artificial Intelligence & Machine Learning, Computer software, CVA - Cerebrovascular Accident, Data processing/analysis, Image/Signal processing, Neurologic disease, PD - Parkinson's Disease
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Selective Human Sirtuin-2 Inhibitors, the Therapeutic Candidate for Huntington's Disease
NU 2012-145InventorsRichard Silverman*Hua WangMohammad KhanfarAleksey KazantsevShort DescriptionSelective human sirtuin-2 inhibitors for use in treating Huntington's diseaseAbstractNorthwestern researchers have discovered a new series of selective human sirtuin-2 inhibitors which show excellent neuronal protection in the Huntington's disease model....
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Stable, Potent Compounds to Selectively Inhibit Neuronal Nitric Oxide Production
NU 2011-053 Inventors Haitao Mark Ji Richard B. Silverman* He Huang Abstract Nitric oxide (NO) is a critical neurotransmitter. Overproduction of NO has been implicated in a variety of neurological diseases, including Parkinson's, Alzheimer's, and Huntington's, as well as neuronal damage occurring in stroke patients. Inhibitors of the enzyme...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, CVA - Cerebrovascular Accident, Neurologic disease, Neurology, PD - Parkinson's Disease, Research reagent, Research tool, Therapeutics
Category(s): Life Sciences > Therapeutics
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