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ACE2+ Exosomes for COVID-19 Decoy Therapy
PROPOSED TITLE: ACE2+ Exosomes for COVID-19 Decoy Therapy
NU NUMBER NU 2020-145
INVENTORS
Deyu Fang*
Huiping Liu*
Andrew Hoffmann
Emma June Schuster
Lamiaa El-Shennawy
Nurmaa Dashzeveg
SHORT DESCRIPTION
This invention provides exosomes loaded with ACE2 protein or viral antigen-specific IgGs for treatment of COVID-19.
BACKGROUND
The COVID-19...
Published: 11/17/2025
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Inventor(s):
Keywords(s): COVID-19, Drug delivery, Infectious disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Self-powered, bioresorbable drug release systems
NU 2023-045
INVENTORS
John Rogers*
Colin Franz*
Yamin Zhang
SHORT DESCRIPTION
Northwestern and Shirley Ryan AbilityLab researchers have developed a novel, self-powered, bioresorbable drug delivery system that enables light-controlled, targeted drug release without the need for surgical removal post-treatment.
BACKGROUND
Current drug delivery systems...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biomaterials, Cancer/Oncology, Drug delivery, Infectious disease, Medical device, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Compositions and Methods for the Treatment of Intestinal Inflammation
NU 2021-252
INVENTORS
Matthew Bury
Muthukumar Gunasekaran
Sunjay Kaushal
Arun Sharma*
Tiffany Sharma
BACKGROUND
Crohn’s Disease (CD) is partly caused by a highly pro-inflammatory lesion microenvironment which subsequently causes numerous clinical complications. Northwestern University scientists have developed a method to control...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Infectious disease
Category(s): Life Sciences > Therapeutics
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Inflammation sensitive bacteria can detect flares of IBD
NU 2023-131
INVENTORS
Jonathan Xia
Arthur Prindle*
BACKGROUND
The prevalence of Inflammatory Bowel Disease (IBD), a spectrum of chronic autoimmune inflammatory disorders of the gastrointestinal tract, has steadily increased from 3.7 million in 1990 to 6.8 million in 2017. The spectrum of diseases are characterized by a relapsing and remitting...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Diagnostics, Gastrointestinal and Hepatic disease, Infectious disease, Inflammation
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Methods and Compounds that block the release of enveloped viruses from cells
NU 2019-084
INVENTORS
Jonathan Leis*
Chi-Hao Luan
SHORT DESCRIPTION
Antiviral agents targeting a broad range of enveloped viruses for pan-viral therapeutics
BACKGROUND
To date, there are very few shared mechanisms identified between families of shared viruses. As such, there is minimal development of a broad-spectrum antiviral. Enveloped viruses...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Immunology, Immunotherapy, Infectious disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Enhancing Gene Silencing by RNAi
NU 2005-063, NU 2005-064, and NU 2006-182 InventorsRichard Carthew* Dinari Harris Young Sik Lee Short DescriptionNovel strategy to improve gene silencing by RNAi for development of therapeutics AbstractRNAi has been proposed as a therapeutic strategy for disorders characterized by aberrant gene overexpression (cancer, macular degeneration etc.) as well...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biologic, Gene therapy, Infectious disease, Research tool, RNA - Ribonucleic Acid, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Therapeutics
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On-mask Chemical Modulation of Respiratory Droplets
NU 2020-180
INVENTORS
Jiaxing Huang*
Haiyue Huang
Hun Park
DESCRIPTION
Mask treatment that chemically deactivates exhaled droplets passing through the mask fabric with anti-pathogenic molecules
BACKGROUND
Transmission of infectious respiratory diseases starts from pathogen-laden droplets released during coughing, sneezing or speaking. Global respiratory...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Chemicals, Coating, COVID-19, Health & Safety, Infectious disease, Materials
Category(s): Physical Sciences > Materials and Industrial Processes
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Antibiotic-Coated Nanoparticles
NU 2016-031INVENTORSAndrew LeeMarc ScheetzAlan Hauser*Nathaniel RhodesSHORT DESCRIPTIONModified nanoparticles that bind and/or kill bacteriaBACKGROUNDThe emergence of bacterial pathogens resistant to many or all conventional antibiotics is a crisis in healthcare. Since current economic models have dissuaded pharmaceutical companies from developing new...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Drug delivery, Infectious disease, Nanoparticle, Therapeutics
Category(s): Life Sciences > Therapeutics
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HIV Therapeutics
NU 2013-216
Inventors
Gary Schiltz*
Chisu Song
Richard D'Aquila
Short Description
Novel small molecule that boosts the innate immune response against viral infection
Abstract
Northwestern researchers have identified a lead compound that can be further developed into a drug for boosting the immune response to HIV and other viral infections....
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biomedical, Infectious disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Prodrugs against S. pneumoniae for Treatment of Pneumonia, Sinusitis, Meningitis, and Other Diseases
NU 2012-018 InventorsRichard B. Silverman* Soosung Kang Mizuki Watanabe AbstractInfection by the Streptococcus pneumoniae bacterium is a significant health risk, particularly for children in developing countries. The incidence of strains of the microbe that are resistant to penicillin and other classic treatments has been on the rise since the mid-1990s....
Published: 11/6/2025
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Inventor(s):
Keywords(s): Infectious disease, Pulmonary disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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