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Epigenetic Gene Editing in Cardiomyopathy to Improve Heart Function
SHORT DESCRIPTION
A precision cardiac gene‑regulation platform that deletes a MYH7 enhancer to shift ventricular myosin isoform balance toward faster α‑MHC and activates upstream MYH6 enhancers to increase MYH6 expression and improve contractility, creating a dual toolkit for disease‑modifying therapy in cardiomyopathy and heart failure.
INVENTORS
Elizabeth...
Published: 5/15/2026
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Updated: 5/12/2026
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Cardiomyopathy, Gene therapy, Regenerative medicine, Therapeutics
Category(s): Life Sciences > Therapeutics
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Northwestern Startup: Syenex, Inc.
Northwestern Inventor:
Joshua Leonard
McCormick School of Engineering
Chemical and Biological Engineering
Syenex builds bioengineering technologies to unlock the future of human health. Leveraging the power of synthetic biology, we design scalable, precision-engineered components, empowering cell and gene therapy developers to cure disease and build...
Published: 5/5/2026
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Updated: 5/5/2026
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Inventor(s):
Keywords(s): Biologic, Biomedical, Drug delivery, Gene therapy, Platform technology, Research tool, Startup with Northwestern IP, Synthetic biology, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Therapeutics
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Precision Gene Therapy for Diseases Driven by Endothelial Dysfunction
SHORT DESCRIPTION
Dual promoter system constructs for tissue-specific and cell-type-specific gene expression, enabling precision gene therapy targeting endothelial dysfunction in specific organs.
INVENTORS
Youyang Zhao*
Ann & Robert H Lurie Children's Hospital of Chicago
* Principal Investigator
NU...
Published: 5/8/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, CMD - Cardiometabolic disease, CPD - Cardiopulmonary disease, Gene therapy, Pulmonary disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease
Category(s): Life Sciences > Therapeutics
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Noninvasive brain-specific inhibition of bone morphogenetic protein signaling for the prevention of tauopathy
NU2025-330
INVENTORS
John Kessler*
Justin Geier
Chian-Yu Peng
SHORT DESCRIPTION
This invention uses a noninvasive gene therapy approach to prevent and treat tauopathies, such as Alzheimer's disease and frontotemporal dementia, by inhibiting bone morphogenetic protein (BMP) specifically within the central nervous system.
BACKGROUND
Tauopathies...
Published: 3/27/2026
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Updated: 3/26/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Gene therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Targeting the IFITM1/OVOL1 Axis for Treating Corneal Wounds
NU 2024-159
INVENTORS
Han Peng*
Robert Lavker
SHORT DESCRIPTION
This invention addresses corneal wound healing by providing methods and compositions to target the IFITM1/OVOL1 axis to modulate limbal epithelial stem cells (LESCs) and early transit amplifying cells (eTAs).
BACKGROUND
Maintaining corneal transparency and vision depends on...
Published: 5/11/2026
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Updated: 11/10/2025
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Inventor(s):
Keywords(s): Gene therapy, Nucleic Acids, Ophthalmic disease, RNA - Ribonucleic Acid, Therapeutics
Category(s): Life Sciences > Therapeutics
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Soft Bio-Integrated Catheter System
NU 2020-150
INVENTORS
John Rogers (Northwestern University, Department of Materials Science and Engineering)*
Igor Efimov (Northwestern University, Department of Biomedical Engineering, Medicine)*
Roozbeh Ghaffari (Northwestern University, Department of Biomedical Engineering)*
Mengdi Han
SHORT DESCRIPTION
This novel catheter platform delivers...
Published: 5/4/2026
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Updated: 11/7/2025
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Inventor(s):
Keywords(s): Gene therapy, Sensors
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Cell-type specific disruption of M1 muscarinic acetylcholine receptor expression to alleviate Parkinson's disease
NU 2024-244
INVENTORS
Dalton J. Surmeier Jr*
Tatiana Tkatch
Shenyu Zhai
SHORT DESCRIPTION
Gene therapy targeting M1 muscarinic receptor expression in striatal spiny projection neurons to enhance levodopa response and slow Parkinson’s Disease progression.
BACKGROUND
Parkinson’s Disease (PD) is the second most common age-related...
Published: 1/5/2026
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Updated: 3/27/2025
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Inventor(s):
Keywords(s): CNS - Central Nervous System, Gene therapy, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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A novel preparation for ultra-small polymer-grafted nanobins for the targeted delivery of biomedicines
NU 2013-210
INVENTORS
SonBinh Nguyen*
Anthony Chipre
SHORT DESCRIPTION
A method of preparation to increase long-term stability and controlled release for ultra-small polymer-grafted nanobins
BACKGROUND
Small unilamellar vesicles (SUVs) are liposomes in 15 – 50 nm range. These components are of growing interest due to their small size, biocompatibility,...
Published: 11/6/2025
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Updated: 6/2/2023
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Inventor(s):
Keywords(s): Biomedical, Devices, Drug delivery, Gene therapy, Health IT, Medical device
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Humanized antibody targeting the tumor associated antigen, IL13Ra2
Humanized antibody targeting the tumor associated antigen, IL13Ra2
NU 2020-031
INVENTORS
Irina Balyasnikova*
SHORT DESCRIPTION
A novel antibody that specifically targets glioblastoma cells
BACKGROUND
Glioblastoma is a deadly, incurable disease with a low 5 year survival rate. The current standard of care typically involves surgical resection...
Published: 3/5/2026
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Updated: 6/1/2023
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Inventor(s):
Keywords(s): Antibody, Cancer/Oncology, CAR T, Cell therapy, Gene therapy, Neurologic disease, Personalized medicine, Research tool, Therapeutics
Category(s): Life Sciences > Therapeutics
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Gene Therapy for Parkinson's Disease
NU 2021-039
INVENTORS
D. James Surmeier*
Michael Kaplitt
Patricia Gonzalez Rodriguez
SHORT DESCRIPTION
A simple neurological procedure to treat late-stage Parkinson’s Disease patients
BACKGROUND
Approximately 60,000 Americans are diagnosed with Parkinson’s Disease (PD) each year. Although levodopa has been the gold-standard for symptomatic...
Published: 1/5/2026
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Updated: 5/27/2022
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Inventor(s):
Keywords(s): CNS - Central Nervous System, Gene therapy, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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