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Nanotherapy to Treat Intestinal Inflammation
NU 2015-160
PRIMARY INVENTOR
Arun Sharma
SHORT DESCRIPTION
Potent anti-inflammatory nanomolecules to treat chronic intestinal inflammation (ileitis) that is detrimental to tissue function
BACKGROUND
Clinical complications of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) can be observed throughout the digestive tract as tissue...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Gastrointestinal and Hepatic disease, Inflammation, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Inflammation sensitive bacteria can detect flares of IBD
NU 2023-131
INVENTORS
Jonathan Xia
Arthur Prindle*
BACKGROUND
The prevalence of Inflammatory Bowel Disease (IBD), a spectrum of chronic autoimmune inflammatory disorders of the gastrointestinal tract, has steadily increased from 3.7 million in 1990 to 6.8 million in 2017. The spectrum of diseases are characterized by a relapsing and remitting...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Diagnostics, Gastrointestinal and Hepatic disease, Infectious disease, Inflammation
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Self-assembling peptides with hyaluronic acid binding domains to form hydrogels
NU 2022-016
INVENTORS
Kyle M. Koss
Terrance J. Sereda*
Jason A. Wertheim*
ABSTRACT
A new class of self-assembling peptides with hyaluronic acid-binding domains shows great promise for biomedical applications, particularly in treating injuries, cancer, and enhancing the function of implantable devices. These peptides self-assemble into nanofibers...
Published: 12/11/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Drug delivery, Enabling technology, Foreign body response, Implantable devices, Inflammation, Lung disease, Wound healing
Category(s): Life Sciences > Therapeutics
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Therapy for acute kidney injury
NU 2022-202
INVENTORS
Pinelopi Kapitsinou*
Ratnakar Tiwari
SHORT DESCRIPTION
Inhibition of MCT4 slows the progression of acute kidney inury to chronic kidney disease
BACKGROUND
Acute kidney inury (AKI) is a sudden onset of kidney dysfunction, often caused by factors such as ischemia, toxins, or infections, leading to impaired filtration and accumulation...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Inflammation, Renal Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Immunomodulatory Nanoparticles for the Therapeutic Intervention of Traumatic Brain Injury
NU 2019-030
INVENTORS
John Kessler
Sripadh Sharma
ABSTRACT
There is no decisive treatment for traumatic brain injury (TBI). After the primary trauma, secondary injury, largely mediated by blood-borne immune cells called monocytes, takes place causing damage to surrounding healthy cells. Furthermore, cellular and whole brain swelling (edema) resulting...
Published: 12/11/2025
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Inventor(s):
Keywords(s): Autoimmune disease, Brain injury, CNS - Central Nervous System, Immunology, Inflammation, Neurologic disease, Neurology, Therapeutics
Category(s): Life Sciences > Therapeutics
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S epidermidis Lipotechoic Acid (SELTA) for Immune Modulation
NU 2014-062INVENTORSStephen F MurphyPraveen Thumbikat*Anthony Schaeffer SHORT DESCRIPTIONA bacterial cell wall component to treat chronic pelvic pain syndrome.BACKGROUNDChronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) is a common debilitating disorder characterized by pelvic pain and lower urinary tract symptoms. However, due to limited understanding...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Arthritis, Biomedical, Immunology, Inflammation, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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A Novel RNA Therapeutic Candidate for Fibrotic Diseases
LU 2015-101 InventorsAnn Harris*Lindsay Stolzenburg Short DescriptionA microRNA drug candidate that treats fibrotic diseases through the repression of TGF-β receptor expression. AbstractNorthwestern researchers have identified an innovative therapeutic strategy to treat acute and chronic fibrotic diseases. Progression of fibrosis involves repeated...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biologic, Inflammation, RNA - Ribonucleic Acid, Therapeutics
Category(s): Life Sciences > Therapeutics
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POP3, a Novel Inflammasome Inhibitor and its Use Of
NU 2010-160 Inventors Christian Stehlik Short DescriptionPOP3 protein as a method to modulate inflammationAbstract Northwestern researchers have identified a new member of the PYD-only protein (POPs) family (POP3) as a specific regulator of ALR inflammasomes, promoting IFN-beta production and reducing IL-1beta and IL-8 production. POP3 has the potential...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Autoimmune disease, Infectious disease, Inflammation, Therapeutics
Category(s): Life Sciences > Therapeutics
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Proteasome Inhibitors as Steroid Therapy Boosters
NU 2010-015 Inventors Irina Budunova* Alexander Yemelyanov Short Description Novel therapy for cancer and other proliferative disorders that relies on the use of an FDA-approved proteasome inhibitor Abstract Northwestern researchers have developed a novel therapeutic strategy to improve glucocorticoid therapy. While glucocorticoids find application...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Inflammation, Therapeutics
Category(s): Life Sciences > Therapeutics
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Novel Anti-Cancer Therapy Using a Stable Analog of a compound from an African Shrub
NU 2006-177 InventorsAlexander Yemelyanov Irina Budunova* AbstractA variety of afflictions‚ including prostate cancer, benign prostate hyperplasia, acne vulgaris, and androgenetic alopecia, have a basis in problematic androgen and/or inflammatory pathways. Northwestern researchers have identified and synthesized a compound (CpdA), a stable analog...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Drug delivery, Inflammation, Therapeutics
Category(s): Life Sciences > Therapeutics
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