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ACE2+ Exosomes for COVID-19 Decoy Therapy
PROPOSED TITLE: ACE2+ Exosomes for COVID-19 Decoy Therapy
NU NUMBER NU 2020-145
INVENTORS
Deyu Fang*
Huiping Liu*
Andrew Hoffmann
Emma June Schuster
Lamiaa El-Shennawy
Nurmaa Dashzeveg
SHORT DESCRIPTION
This invention provides exosomes loaded with ACE2 protein or viral antigen-specific IgGs for treatment of COVID-19.
BACKGROUND
The COVID-19...
Published: 11/17/2025
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Inventor(s):
Keywords(s): COVID-19, Drug delivery, Infectious disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169
INVENTORS
Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN))
Brian Meckes
Wuliang Zhang
SHORT DESCRIPTION
For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 11/7/2025
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Inventor(s):
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
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Fungal Natural Product Discovery Using FAC-MS Technology
NU 2016-068
INVENTORS
Neil Kelleher*
Kenneth Clevenger
Paul Thomas
SHORT DESCRIPTION
This platform uses fungal artificial chromosomes and ultra‐high mass accuracy LC-MS to profile secondary metabolites. It offers a rapid, scalable approach for natural product discovery in drug and agricultural research.
BACKGROUND
Current natural product...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Therapeutics
Category(s): Life Sciences > Therapeutics
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Clinical Bacterial Isolate Engineered as Prostate Cancer Immunotherapy
NU 2015-087
INVENTORS
Praveen Thumbikat*
Anthony Schaeffer
Jonathan Anker
Sarki Abdulkadir
SHORT DESCRIPTION
This technology uses a genetically modified CP1 E. coli as an immunotherapeutic agent for prostate cancer. It offers a non-invasive treatment option designed to stimulate an immune response in both early stage and advanced disease.
BACKGROUND
Existing...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Therapeutics
Category(s): Life Sciences > Therapeutics
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A Novel Combination Therapy for Parkinson’s Disease
NU 2013-149
INVENTORS
Dalton Surmeier Jr. (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience)*
Daniel Galtieri
Ema Ilijic
Enrico Zampese
Jaime Guzman-Lucero
Javier Sanchez
SHORT DESCRIPTION
This technology uses a low-dose combination of two FDA-approved compounds to reduce oxidative stress in neurons...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biomedical, Drug delivery, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Targeted Therapy for Glioblastoma via Purine Metabolism Modulation
NU 2019-086
INVENTORS
Atique Ahmed*
Cheol Park
Jack Shireman
SHORT DESCRIPTION
This technology introduces a targeted approach for glioblastoma treatment that modulates purine biosynthesis by targeting the ARL13B-IMPDH2 interaction using repurposed FDA-approved and internationally-used drugs.
BACKGROUND
Glioblastoma is an incurable, aggressive...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Repurposed Drugs, Therapeutics
Category(s): Life Sciences > Therapeutics
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A targeted and localizing anticoagulation therapy
NU 2016-126
INVENTORS
Guillermo Ameer*
Yunxiao Zhu
SHORT DESCRIPTION
This technology employs a novel conjugation method that attaches a fibrin binding peptide (CREKA) to
heparin, ensuring targeted localization and maintained anticoagulant activity for medical devices.
BACKGROUND
Current anticoagulation strategies typically...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Therapeutics
Category(s): Life Sciences > Therapeutics
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Bone-Promoting Thermoresponsive Macromolecules
PROPOSED TITLE
Bone-Promoting Thermoresponsive Macromolecules
NU 2016-201
INVENTORS
Guillermo Ameer*
Simona Morochnik
SHORT DESCRIPTION
Injectable, thermoresponsive PPCN-based hydrogels that are liquid at room temperature and gel at body temperature to provide controlled release of therapeutic agents and promote bone repair and formation.
BACKGROUND
The...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Therapeutics
Category(s): Life Sciences > Therapeutics
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Self-powered, bioresorbable drug release systems
NU 2023-045
INVENTORS
John Rogers*
Colin Franz*
Yamin Zhang
SHORT DESCRIPTION
Northwestern and Shirley Ryan AbilityLab researchers have developed a novel, self-powered, bioresorbable drug delivery system that enables light-controlled, targeted drug release without the need for surgical removal post-treatment.
BACKGROUND
Current drug delivery systems...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biomaterials, Cancer/Oncology, Drug delivery, Infectious disease, Medical device, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Small molecule inhibits the interaction between tristetraprolin and CNOT1 for therapeutic use in metabolic disorders
NU 2024-057
INVENTORS
Hossein Ardehali*
Jason Shapiro
SHORT DESCRIPTION
Compound that inhibits the interaction between tristetraprolin (TTP) and CCR4-NOT Transcription Complex Subunit 1 (CNOT1) offers potential therapeutic avenue for metabolic disorders by modulating mRNA degradation without inflammatory side effects.
BACKGROUND
Metabolic disorders...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Diabetes, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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