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Precision Gene Therapy for Diseases Driven by Endothelial Dysfunction
SHORT DESCRIPTION
Dual promoter system constructs for tissue-specific and cell-type-specific gene expression, enabling precision gene therapy targeting endothelial dysfunction in specific organs.
INVENTORS
Youyang Zhao*
Ann & Robert H Lurie Children's Hospital of Chicago
* Principal Investigator
NU...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, CMD - Cardiometabolic disease, CPD - Cardiopulmonary disease, Gene therapy, Pulmonary disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease
Category(s): Life Sciences > Therapeutics
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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION
Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma.
INVENTORS
Amy Heimberger*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
* Principal Investigator
NU 2025-212
IP STATUS
US...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunology, Immunotherapy, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Selective PAD2 Inhibitors for Neuroprotection in Traumatic Brain Injury
SHORT DESCRIPTION
Novel PAD2-selective inhibitor platform targeting neuroinflammation to support both acute neuroprotection and long-term functional recovery as a first-in-class treatment of traumatic brain injury.
INVENTORS
Hasan Alam*
Northwestern University Feinberg School of Medicine, Department of Surgery (Trauma...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): CNS - Central Nervous System, CVA - Cerebrovascular Accident, Neurodegenerative disease, Neuroinflammation, Neurologic disease, Neurology, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics
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Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets
SHORT DESCRIPTION
A targeted-protein degradation platform for intracellular targets, addressing resistant oncogenic and neurodegenerative targets.
INVENTORS
Shana Kelley*
Weinberg College of Arts & Sciences, Department of Chemistry
Yi Li
* Principal Investigator
NU 2025-050
IP STATUS
PCT...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Biologic, Biomolecular condensates, Cancer/Oncology, Drug delivery, Nanoparticle, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Platform technology, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Methods to Treat Neurodegenerative Disorders by Reducing Nuclear Aggregates and Modulating Adenosine‑to‑Inosine RNA Editing
SHORT DESCRIPTION
Novel disease‑modifying approach that dissolves toxic nuclear RNA–protein aggregates and restores synaptic function in neurodegenerative diseases by inhibiting adenosine‑to‑inosine (A‑to‑I) RNA editing and modulating ADAR enzymes.
INVENTORS
Joseph Mazzulli*
Northwestern University Feinberg School...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): Lewy bodies, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, RNA - Ribonucleic Acid, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Mitigating aberrant Cdk5 Activation in SMA – A Novel Therapeutic Strategy Targeting Mitochondrial Function
SHORT DESCRIPTION
A targeted strategy that mitigates aberrant Cdk5 activity to restore mitochondrial function and reduce motor neuron degeneration in SMA models.
INVENTORS
Yongchao Ma*
Northwestern University Feinberg School of Medicine, Department of Pediatrics
* Principal Investigator
NU Tech...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): Adjunct therapy, Neurodegenerative disease, Neurologic disease, Neurology, Rare diseases, SMA - Spinal muscular atrophy, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Use of Neuronal NOS Inhibitors for Alzheimer's Therapeutic Intervention
PROPOSED TITLE (cut & paste into Alternate Title): Use of Neuronal NOS Inhibitors for Alzheimer's Therapeutic Intervention
NU 2023-007
SHORT DESCRIPTION
A small molecule based approach that mitigates Alzheimer's neurodegeneration by inhibiting neuronal nitric oxide synthase to prevent tau phosphorylation and reduce Aβ oligomer formation.
INVENTORS
Richard...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Covalent inhibitor, Kinase Inhibitor, Neurodegenerative disease, Neurology, nNOS, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Inhibitors of TRIP8b for Novel Mood Disorder Therapeutics
SHORT DESCRIPTION For mood disorder treatment, these novel inhibitors disrupt TRIP8b-HCN binding to offer an alternative antidepressant mechanism.
INVENTORS
Gary Schiltz*
Weinberg College of Arts and Sciences, Department of Chemistry
Dane Chetkovich
Ye Han
Iredia Iyamu
Kyle Lyman
* Principal...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): Antidepressant, Depression, Mood disorder, Neurologic disease, Neurology, Psychiatric disease, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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SEC61 Complex as a Novel Therapeutic Target to Enhance Immunotherapy Response in Glioblastoma
NU 2023-011
INVENTORS
Irina Balyasnikova*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
Joseph Duffy
SHORT DESCRIPTION
A targeted therapeutic approach that inhibits the SEC61 complex to enhance responses to immunotherapy in glioblastoma.
BACKGROUND
Glioblastoma (GBM) is the most aggressive primary...
Published: 4/14/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Brain cancer, Cancer/Oncology, Immunotherapy, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Anti-TYRP1 Bi-specific T cell Engager for Treatment of TYRP1-expressing melanoma
NU 2022-123
INVENTORS
Irina Balyasnikova (Feinberg School of Medicine, Department of Neurological Surgery)*
Isabelle Le Poole (Feinberg School of Medicine, Department of Dermatology)*
SHORT DESCRIPTION
A bispecific T cell engager that targets CD3+ T cells and TYRP1-expressing melanoma cells.
BACKGROUND
Melanoma is the deadliest form of skin...
Published: 4/14/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Biologic, Cancer/Oncology, Immunotherapy, Melanoma, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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