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Safe, Automated, And High Yielding Method For Synthesizing Deoxyoligonucleicguanidines (DNG) Strands
NU 2019-109
SHORT DESCRIPTION
Spherical nucleic acids (SNAs) incorporating deoxynucleic guanidine (DNG)-modified oligonucleotides enable improved cellular uptake and intracellular delivery by introducing positively charged backbone modifications.
BACKGROUND
Oligonucleotide therapeutics, including antisense and RNA interference (RNAi) approaches,...
Published: 5/21/2026
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Updated: 5/18/2026
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Inventor(s):
Keywords(s): Drug delivery, Nucleic Acids, Platform technology, Research tool
Category(s): Life Sciences > Therapeutics
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Targeted Nanoparticle-Mediated HIF Stabilization in Myeloid Cells for Enhanced Transplant Tolerance
SHORT DESCRIPTION
A PEG-PPS nanoparticle technology for targeted delivery of roxadustat to myeloid cells to promote transplantation tolerance.
INVENTORS
Edward Thorp*
Northwestern University Feinberg School of Medicine, Department of Pathology
Evan Scott*
McCormick School of Engineering, Department...
Published: 5/7/2026
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Updated: 5/7/2026
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Inventor(s):
Keywords(s): Drug delivery, Immunotherapy, Nanoparticle, Therapeutics, Tolerance induction, Transplantation
Category(s): Life Sciences > Therapeutics
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Northwestern Startup: Syenex, Inc.
Northwestern Inventor:
Joshua Leonard
McCormick School of Engineering
Chemical and Biological Engineering
Syenex builds bioengineering technologies to unlock the future of human health. Leveraging the power of synthetic biology, we design scalable, precision-engineered components, empowering cell and gene therapy developers to cure disease and build...
Published: 5/5/2026
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Updated: 5/5/2026
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Inventor(s):
Keywords(s): Biologic, Biomedical, Drug delivery, Gene therapy, Platform technology, Research tool, Startup with Northwestern IP, Synthetic biology, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Therapeutics
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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION
Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma.
INVENTORS
Amy Heimberger*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
* Principal Investigator
NU Tech ID: NU 2025-212
IP...
Published: 5/7/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets
SHORT DESCRIPTION
A targeted-protein degradation platform for intracellular targets, addressing resistant oncogenic and neurodegenerative targets.
INVENTORS
Shana Kelley*
Weinberg College of Arts & Sciences, Department of Chemistry
Yi Li
* Principal Investigator
NU Tech ID: NU 2025-050
IP...
Published: 5/7/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Biologic, Biomolecular condensates, Cancer/Oncology, Drug delivery, Nanoparticle, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Platform technology, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Nano-therapeutics Targeting Cholesterol Efflux Transporter in Macrophages for Cancer Immunotherapy
NU 2025-160
INVENTORS
Jason Miska*
Feinberg School of Medicine, Department of Neurological Surgery
Peng Zhang*
Feinberg School of Medicine, Department of Neurological Surgery
SHORT DESCRIPTION
Novel nanoparticle technology that modulates macrophage cholesterol metabolism to boost anti-tumor immunity in GBM.
BACKGROUND
Glioblastoma...
Published: 4/16/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Adjunct therapy, Brain cancer, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunotherapy, Nanoparticle, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Bi-specific Lipid Nanoparticles for Boosting Antitumor Immunity in Glioblastoma
SHORT DESCRIPTION
A bispecific lipid nanoparticle that bridges tumor-associated myeloid cells (TAMCs) and glioma cells by dual checkpoint blockade and simultaneously reprograms TAMCs into antitumor effectors via targeted delivery of a STING agonist.
INVENTORS
Maciej Lesniak*
Northwestern University Feinberg School of Medicine,...
Published: 4/30/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Brain cancer, Cancer/Oncology, Drug delivery, Immunotherapy, Nanoparticle, Nanotechnology, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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ACE2+ Exosomes for COVID-19 Decoy Therapy
PROPOSED TITLE: ACE2+ Exosomes for COVID-19 Decoy Therapy
NU NUMBER NU 2020-145
INVENTORS
Deyu Fang*
Huiping Liu*
Andrew Hoffmann
Emma June Schuster
Lamiaa El-Shennawy
Nurmaa Dashzeveg
SHORT DESCRIPTION
This invention provides exosomes loaded with ACE2 protein or viral antigen-specific IgGs for treatment of COVID-19.
BACKGROUND
The COVID-19...
Published: 4/13/2026
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Updated: 11/17/2025
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Inventor(s):
Keywords(s): COVID-19, Drug delivery, Infectious disease, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Closed-Loop Implantable System for Automated Opioid Overdose Detection and Reversal
NU 2019-073
INVENTORS
John Rogers (Northwestern University)*
Robert Gereau (Washington University, St Louis)*
SHORT DESCRIPTION
This wireless device, the size of a pacemaker, is implanted to monitor oxygen levels. Below a specific threshold, it sends an alert to warning notification on a mobile app, then automatically releases naloxone to prevent...
Published: 12/9/2025
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Updated: 11/7/2025
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Inventor(s):
Keywords(s): Drug delivery, Electronics & Circuits, Medical device, Microfluidics
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
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Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169
INVENTORS
Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN))
Brian Meckes
Wuliang Zhang
SHORT DESCRIPTION
For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 12/9/2025
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Updated: 10/30/2025
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Inventor(s):
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
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