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ACE2+ Exosomes for COVID-19 Decoy Therapy
PROPOSED TITLE: ACE2+ Exosomes for COVID-19 Decoy Therapy
NU NUMBER NU 2020-145
INVENTORS
Deyu Fang*
Huiping Liu*
Andrew Hoffmann
Emma June Schuster
Lamiaa El-Shennawy
Nurmaa Dashzeveg
SHORT DESCRIPTION
This invention provides exosomes loaded with ACE2 protein or viral antigen-specific IgGs for treatment of COVID-19.
BACKGROUND
The COVID-19...
Published: 11/17/2025
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Inventor(s):
Keywords(s): COVID-19, Drug delivery, Infectious disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Closed-Loop Implantable System for Automated Opioid Overdose Detection and Reversal
NU 2019-073
INVENTORS
John Rogers (Northwestern University)*
Robert Gereau (Washington University, St Louis)*
SHORT DESCRIPTION
This wireless device, the size of a pacemaker, is implanted to monitor oxygen levels. Below a specific threshold, it sends an alert to warning notification on a mobile app, then automatically releases naloxone to prevent...
Published: 11/7/2025
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Inventor(s):
Keywords(s): Drug delivery, Electronics & Circuits, Medical device, Microfluidics
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
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Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169
INVENTORS
Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN))
Brian Meckes
Wuliang Zhang
SHORT DESCRIPTION
For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 11/7/2025
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Inventor(s):
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
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Methods for assembling peptides into peptide amphiphile nanofibers
TITLE: Peptide Nanofiber Assembly for Enhanced Therapeutic Delivery
NU 2020-081
SHORT DESCRIPTION
This technology uses self-assembling peptide amphiphile nanofibers to protect and deliver therapeutic peptides. It reduces degradation and improves delivery efficiency for advanced treatment applications.
BACKGROUND
Peptide therapeutics offer promise...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Drug delivery, Nanomaterials
Category(s): Life Sciences > Therapeutics
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BDNF Mimetic Peptide Amphiphile for Enhanced Neurotrophic Signaling and Neuronal Regeneration
NU 2018-020
INVENTORS
Samuel Stupp
Alexandra Kolberg
Zaida Alvarez Pinto
SHORT DESCRIPTION
This technology is an injectable, highly potent peptide amphiphile that mimics BDNF function via the TrkB pathway while providing extracellular support. It promotes neuronal growth and signaling for regenerative treatments in CNS injuries and diseases.
BACKGROUND
Current...
Published: 11/6/2025
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Inventor(s):
Keywords(s): CNS - Central Nervous System, Devices, Drug delivery, Health IT, Medical device
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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A Novel Combination Therapy for Parkinson’s Disease
NU 2013-149
INVENTORS
Dalton Surmeier Jr. (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience)*
Daniel Galtieri
Ema Ilijic
Enrico Zampese
Jaime Guzman-Lucero
Javier Sanchez
SHORT DESCRIPTION
This technology uses a low-dose combination of two FDA-approved compounds to reduce oxidative stress in neurons...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biomedical, Drug delivery, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Self-powered, bioresorbable drug release systems
NU 2023-045
INVENTORS
John Rogers*
Colin Franz*
Yamin Zhang
SHORT DESCRIPTION
Northwestern and Shirley Ryan AbilityLab researchers have developed a novel, self-powered, bioresorbable drug delivery system that enables light-controlled, targeted drug release without the need for surgical removal post-treatment.
BACKGROUND
Current drug delivery systems...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biomaterials, Cancer/Oncology, Drug delivery, Infectious disease, Medical device, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Sliding Bioactive Peptides for Therapeutic Delivery
NU 2023-142
INVENTORS
Samuel I. Stupp*
Federico Lancia
Madison E. Strong
Matias A. Alvarez-Saavedra
SHORT DESCRIPTION
This technology involves the design and engineering of peptide amphiphile nanofibers that deliver bioactive peptides both extra- and intra-cellularly. The bioactive peptides can slide along these structures...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biomaterials, Drug delivery
Category(s): Life Sciences > Therapeutics
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Engineered Lipid Tags for Extracellular Vesicle Loading
NU 2022-178
INVENTORS
Neha Kamat*
Joshua Leonard*
Justin Alexander Peruzzi
Taylor Gunnels
SHORT DESCRIPTION
This technology enhances the loading of protein cargo into extracellular vesicles (EVs) by directing protein association with membrane lipid rafts, utilizing engineered lipid tags for targeted delivery.
BACKGROUND
Extracellular...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biotechnology, Drug delivery, Nanoparticle, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Leveraging Lipid-Protein Interactions to Engineer Spatial Organization in Cell-free Systems
NU 2021-231
INVENTORS
Neha Kamat*
Justin Alexander Peruzzi
Jan Steinkuehler
SHORT DESCRIPTION
This innovative method enables the control of membrane protein location and distribution in synthetic lipid membranes using lipid-protein interactions, without chemical conjugation, facilitating the development of advanced cell-free systems.
BACKGROUND
Spatially...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biotechnology, Drug delivery, Nanoparticle, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Physical Sciences > Engineering & Technology
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