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Antibodies for treatment of coronavirus disease
NU 2023-247
INVENTORS
Huiping Liu*
Deyu Fang*
Hannah Mubarak
Andrew Hoffmann
Nurmaa Dashzeveg
Lamiaa El-Shennawy
Juncheng Wei
Wuwei Tan
Yang Shen
SHORT DESCRIPTION
Computationally redesigned antibodies targeting SARS-CoV-2 for treating COVID-19.
BACKGROUND
The continuous evolution of SARS-CoV-2 has allowed the virus to escape most therapeutic...
Published: 2/26/2026
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Updated: 2/26/2026
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Inventor(s):
Keywords(s): Antibody, Artificial Intelligence & Machine Learning, Biologic, Infectious disease, Research tool, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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The use of complex or fusion protein of soluble MIC (Smic) and antibody to treat MIC-negative cancer
NU 2019-146
INVENTORS
Jennifer Wu*
SHORT DESCRIPTION
A fusion protein complex comprising soluble MIC and a non-blocking sMIC-neutralizing antibody that effectively activates CD8 T cells for the treatment of MIC-negative cancer.
BACKGROUND
Effective T cell co-stimulation is critical for durable tumor control, yet many current immunotherapies...
Published: 4/9/2026
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Updated: 12/3/2025
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Inventor(s):
Keywords(s): Antibody, Biologic, Cancer/Oncology, Immunotherapy, Infectious disease, Research tool, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169
INVENTORS
Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN))
Brian Meckes
Wuliang Zhang
SHORT DESCRIPTION
For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 12/9/2025
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Updated: 10/30/2025
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Inventor(s):
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
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Inflammation sensitive bacteria can detect flares of IBD
NU 2023-131
INVENTORS
Jonathan Xia
Arthur Prindle*
BACKGROUND
The prevalence of Inflammatory Bowel Disease (IBD), a spectrum of chronic autoimmune inflammatory disorders of the gastrointestinal tract, has steadily increased from 3.7 million in 1990 to 6.8 million in 2017. The spectrum of diseases are characterized by a relapsing and remitting...
Published: 3/26/2026
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Updated: 10/17/2024
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Inventor(s):
Keywords(s): Biologic, Diagnostics, Gastrointestinal and Hepatic disease, IBD - Inflammatory bowel disease, Infectious disease, Inflammation, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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A CSF-derived therapy for psychiatric disorders
NU2023-196
INVENTORS
Peter Penzes*
Marc Dos Santos
BACKGROUND
Currently, there is a lack of treatments which address the negative and cognitive symptoms of psychiatric disorders such as schizophrenia. Northwestern researchers have designed a recombinant form of ⍺2d-1 protein, a subunit of the voltage-gated calcium channel, to restore protein...
Published: 12/23/2025
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Updated: 10/17/2024
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Inventor(s):
Keywords(s): Biologic, Neurologic disease, Neurology, PSD - Psychotic spectrum disorder, Psychiatric disease, Schizophrenia, Therapeutics
Category(s): Life Sciences > Therapeutics
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Enhancing Gene Silencing by RNAi
NU 2005-063, NU 2005-064, and NU 2006-182 InventorsRichard Carthew* Dinari Harris Young Sik Lee Short DescriptionNovel strategy to improve gene silencing by RNAi for development of therapeutics AbstractRNAi has been proposed as a therapeutic strategy for disorders characterized by aberrant gene overexpression (cancer, macular degeneration etc.) as well...
Published: 3/19/2026
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Updated: 5/25/2022
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Inventor(s):
Keywords(s): Biologic, Gene therapy, Infectious disease, Research tool, RNA - Ribonucleic Acid, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Therapeutics
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Reelin for the Clinical Treatment of Cardiac Pathologies
NU 2020-159
INVENTORS
Guillermo Oliver*
Xialoei Liu
SHORT DESCRIPTION
A novel approach to treating cardiovasculature disease
BACKGROUND
Although little is known about the role of cardiac lymphatics in the healthy or failing heart, a growing body of evidence indicates that improved cardiac lymphatic vessel growth and function could be a novel therapeutic...
Published: 12/11/2025
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Updated: 8/10/2021
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Inventor(s):
Keywords(s): Biologic, Cardiology and Cardiovascular disease, Regenerative medicine, Therapeutics
Category(s): Life Sciences > Therapeutics
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HPS1 and HPS4 Function as RNAi Inhibitors: A Means to Boost RNAi for Experimental, Therapeutic & Commercial Purposes
NU 2005-063BInventorsRichard Carthew* Dinari Harris Young Sik Lee Short DescriptionNovel strategy to improve gene silencing by RNAi for development of therapeutics AbstractRNAi has been proposed as a therapeutic strategy for disorders characterized by aberrant gene overexpression (cancer, macular degeneration etc.) as well as for controlling viral infections....
Published: 11/6/2025
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Updated: 10/15/2019
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Inventor(s):
Keywords(s): Assay, Biologic, Gene therapy, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Therapeutics
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A Novel RNA Therapeutic Candidate for Fibrotic Diseases
LU 2015-101 InventorsAnn Harris*Lindsay Stolzenburg Short DescriptionA microRNA drug candidate that treats fibrotic diseases through the repression of TGF-β receptor expression. AbstractNorthwestern researchers have identified an innovative therapeutic strategy to treat acute and chronic fibrotic diseases. Progression of fibrosis involves repeated...
Published: 3/19/2026
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Updated: 5/24/2019
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Inventor(s):
Keywords(s): Biologic, Inflammation, RNA - Ribonucleic Acid, Therapeutics
Category(s): Life Sciences > Therapeutics
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Development of Neuroprotective Therapeutics Based on Stroke-Induced Secretory Proteins
NU 2010-125InventorShu Q. LiuShort Description A biologic for neuroprotection during the acute phase of a strokeBackgroundStroke is the leading cause of serious, long-term disability in the United States. As adult neurons possess a limited capacity for protection and regeneration, infarcted brain tissue is often replaced with fibrotic tissues, resulting...
Published: 3/19/2026
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Updated: 4/9/2019
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Inventor(s):
Keywords(s): Biologic, CVA - Cerebrovascular Accident, Neurologic disease, Neurology, Therapeutics
Category(s): Life Sciences > Therapeutics
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