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Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169
INVENTORS
Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN))
Brian Meckes
Wuliang Zhang
SHORT DESCRIPTION
For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 11/7/2025
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Inventor(s):
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
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A CSF-derived therapy for psychiatric disorders
NU2023-196
INVENTORS
Peter Penzes*
Marc Dos Santos
BACKGROUND
Currently, there is a lack of treatments which address the negative and cognitive symptoms of psychiatric disorders such as schizophrenia. Northwestern researchers have designed a recombinant form of ⍺2d-1 protein, a subunit of the voltage-gated calcium channel, to restore protein...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biologic, Psychiatric disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Enhancing Gene Silencing by RNAi
NU 2005-063, NU 2005-064, and NU 2006-182 InventorsRichard Carthew* Dinari Harris Young Sik Lee Short DescriptionNovel strategy to improve gene silencing by RNAi for development of therapeutics AbstractRNAi has been proposed as a therapeutic strategy for disorders characterized by aberrant gene overexpression (cancer, macular degeneration etc.) as well...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biologic, Gene therapy, Infectious disease, Research tool, RNA - Ribonucleic Acid, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Therapeutics
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Reelin for the Clinical Treatment of Cardiac Pathologies
NU 2020-159
INVENTORS
Guillermo Oliver*
Xialoei Liu
SHORT DESCRIPTION
A novel approach to treating cardiovasculature disease
BACKGROUND
Although little is known about the role of cardiac lymphatics in the healthy or failing heart, a growing body of evidence indicates that improved cardiac lymphatic vessel growth and function could be a novel therapeutic...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biologic, Cardiology and Cardiovascular disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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HPS1 and HPS4 Function as RNAi Inhibitors: A Means to Boost RNAi for Experimental, Therapeutic & Commercial Purposes
NU 2005-063BInventorsRichard Carthew* Dinari Harris Young Sik Lee Short DescriptionNovel strategy to improve gene silencing by RNAi for development of therapeutics AbstractRNAi has been proposed as a therapeutic strategy for disorders characterized by aberrant gene overexpression (cancer, macular degeneration etc.) as well as for controlling viral infections....
Published: 11/6/2025
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Inventor(s):
Keywords(s): Assay, Biologic, Gene therapy, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Therapeutics
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A Novel RNA Therapeutic Candidate for Fibrotic Diseases
LU 2015-101 InventorsAnn Harris*Lindsay Stolzenburg Short DescriptionA microRNA drug candidate that treats fibrotic diseases through the repression of TGF-β receptor expression. AbstractNorthwestern researchers have identified an innovative therapeutic strategy to treat acute and chronic fibrotic diseases. Progression of fibrosis involves repeated...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biologic, Inflammation, RNA - Ribonucleic Acid, Therapeutics
Category(s): Life Sciences > Therapeutics
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Development of Neuroprotective Therapeutics Based on Stroke-Induced Secretory Proteins
NU 2010-125InventorShu Q. LiuShort Description A biologic for neuroprotection during the acute phase of a strokeBackgroundStroke is the leading cause of serious, long-term disability in the United States. As adult neurons possess a limited capacity for protection and regeneration, infarcted brain tissue is often replaced with fibrotic tissues, resulting...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biologic, CVA - Cerebrovascular Accident, Neurologic disease, Neurology, Therapeutics
Category(s): Life Sciences > Therapeutics
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New Peptide Amphiphiles Bearing the Laminin Peptide Sequence IKVAV with Ability to Promote Neurite Outgrowth
NU 2010-183 Inventors Joshua Goldberger Eric J. Berns Samuel I. Stupp* Short DescriptionNovel peptides that promote neurite growth with therapeutic applications. Abstract Northwestern researchers have created improved peptide amphiphiles bearing the laminin sequence IKVAV that promote neurite outgrowth. Synthesis and purification of these peptide...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biologic, Devices, Health IT, Medical device, Neurologic disease, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Novel Peptide Compounds with Enhanced Anti-Tumor Activity
NU 2002-081, NU 2003-053 and NU 2004-095InventorsThomas Adrian Wenxin Gu Shouxin Liu Richard Silverman* Gerald Soff Short DescriptionSynthesis of a novel family of peptide compounds with increased anti-proliferative activity AbstractNorthwestern researchers have synthesized novel peptides based upon natural marine products that exhibit cytotoxicity...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biologic, Cancer/Oncology, Therapeutics
Category(s): Life Sciences > Therapeutics
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Maspin for Osteoporosis Treatment
NU 2007-156 Inventors Ming Zhang Short Description Maspin, a tumor-suppressing protein, stimulates bone cell proliferation for treatment of osteoporosis AbstractA Northwestern researcher has discovered that maspin, a well-known anti-cancer protein, can also stimulate proliferation of bone cells. Maspin is able to modulate osteoblast proliferation...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biologic, Osteoporosis, Therapeutics
Category(s): Life Sciences > Therapeutics
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