|
Anti-CD73 Monoclonal Antibody for Enhanced Cancer Immunotherapy
NU 2020-207
INVENTORS
Bin Zhang*
Siqi Chen
Jie Fan
SHORT DESCRIPTION
This invention comprises novel anti-CD73 monoclonal antibody compositions that recognize and inhibit mouse and human CD73.
BACKGROUND
CD73, an ecto-enzyme associated with adenosine metabolism, is an emerging immune checkpoint that promotes tumor progression by suppressing...
Published: 12/11/2025
|
Inventor(s):
Keywords(s): Brain cancer, Breast cancer, Cancer/Oncology, Colon cancer, Gastric cancer, Immunotherapy, Lung cancer, Ovarian cancer, Pancreatic cancer, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Novel Delivery System for BMP4 for the Treatment of Pediatric High-Grade Glioma
NU 2020-051
INVENTORS
Samuel I. Stupp
SHORT DESCRIPTION
A novel delivery system for bone morphogenetic protein 4 utilizing nanotechnology.
BACKGROUND
Pediatric high-grade glioma (HGG) is among the most formidable cancer occurring in childhood patients. Current treatments include surgery followed by chemo- and radiation therapy but, these have...
Published: 1/9/2026
|
Inventor(s):
Keywords(s): Biomaterials, Brain cancer, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Nanomaterials, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
IDO-PROTACs for Improving the Anti-Cancer Immune Response
NU 2020-137
INVENTORS
Derek Wainwright*
Gary Schiltz
SHORT DESCRIPTION
IDO-PROTAC that target immunosuppressive IDO activity via degradation
ABSTRACT
The median survival of primary GBM patients following aggressive surgical intervention, radiotherapy, chemotherapy, and tumor treating fields (TTF) is only ~14-16 months. Indoleamine 2,3-dioxygenase...
Published: 3/3/2026
|
Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Brain cancer, Cancer/Oncology, Colon cancer, Endometrial cancer, Immunotherapy, Pancreatic cancer, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
|