|
Potent and selective Cav1.3 negative allosteric modulators for use in Parkinson's Disease
NU 2010-105 and NU 2024-179
INVENTORS
Richard Silverman* (Northwestern University, Weinberg College of Arts & Science, Department of Chemistry)
Dalton Surmeier Jr.* (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience)
Garry Cooper
Soosung Kang
Jack Nguyen
SHORT DESCRIPTION
For pharmaceutical...
Published: 11/11/2025
|
Inventor(s):
Keywords(s): Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
|
|
A Biological Marker for Concussion
NU 2016-016
INVENTORS
Nina Kraus*
Trent Nicol
Travis White-Schwoch
SHORT DESCRIPTION
This technology provides a method for objectively identifying non-penetrating brain injuries by analyzing the brain’s frequency following response (FFR) to an acoustic stimulus. It offers a non-invasive alternative that improves diagnostic precision and...
Published: 11/7/2025
|
Inventor(s):
Keywords(s): Biomarker, Brain injury, Devices, Diagnostics, Electrophysiology, Health IT, Medical device, Neurologic disease, Research tool
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
|
|
A Novel Combination Therapy for Parkinson’s Disease
NU 2013-149
INVENTORS
Dalton Surmeier Jr. (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience)*
Daniel Galtieri
Ema Ilijic
Enrico Zampese
Jaime Guzman-Lucero
Javier Sanchez
SHORT DESCRIPTION
This technology uses a low-dose combination of two FDA-approved compounds to reduce oxidative stress in neurons...
Published: 11/6/2025
|
Inventor(s):
Keywords(s): Biomedical, Drug delivery, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Cell-type specific disruption of M1 muscarinic acetylcholine receptor expression to alleviate Parkinson's disease
NU 2024-244
INVENTORS
Dalton J. Surmeier Jr*
Tatiana Tkatch
Shenyu Zhai
SHORT DESCRIPTION
Gene therapy targeting M1 muscarinic receptor expression in striatal spiny projection neurons to enhance levodopa response and slow Parkinson’s Disease progression.
BACKGROUND
Parkinson’s Disease (PD) is the second most common age-related...
Published: 11/6/2025
|
Inventor(s):
Keywords(s): CNS - Central Nervous System, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
|
|
Gene therapy for levodopa-induced dyskinesia
NU 2024-086
INVENTORS
Dalton J. Surmeier Jr*
Weixing Shen
Shenyu Zhai
Tatiana Tkatch
Qiaoling Cui
Zhong Xie
SHORT DESCRIPTION
Gene therapy targeting GRIN2B in striatal spiny projection neurons to treat levodopa-induced dyskinesia.
BACKGROUND
Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease...
Published: 11/6/2025
|
Inventor(s):
Keywords(s): CNS - Central Nervous System, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
|
|
A peptidomimetic for LIMP-2 based activation of Glucocerebrosidase as a Gaucher/Parkinson’s Disease therapeutic
NU 2016-019
INVENTORS
Dimitri Krainc*
Michael Schwake
SHORT DESCRIPTION
LIMP-2-based peptidomimetic compounds to facilitate glucocerebrosidase activation in Gaucher and Parkinson’s Disease
BACKGROUND
Mutations in glucocerebrosidase (GCase) cause Gaucher Disease. Additionally, GCase mutations are a major risk factor in Parkinson’s Disease,...
Published: 11/6/2025
|
Inventor(s):
Keywords(s): Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
A new CNS-available formulation HDACi for management of chronic pain
A new CNS-available formulation HDACi for management of chronic pain
NU 2017-031
INVENTORS
Vania A. Apkarian*
Kasturi Haldar
Maria V. Centeno
Suhail Alam
SHORT DESCRIPTION
A novel non-opioid, epigenetic drug for pain relief
BACKGROUND
Chronic pain is a major public health problem, and it is the number one source of disability in the...
Published: 11/11/2025
|
Inventor(s):
Keywords(s): Biomedical, Chronic pain, Neurologic disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Humanized antibody targeting the tumor associated antigen, IL13Ra2
Humanized antibody targeting the tumor associated antigen, IL13Ra2
NU 2020-031
INVENTORS
Irina Balyasnikova*
SHORT DESCRIPTION
A novel antibody that specifically targets glioblastoma cells
BACKGROUND
Glioblastoma is a deadly, incurable disease with a low 5 year survival rate. The current standard of care typically involves surgical resection...
Published: 11/6/2025
|
Inventor(s):
Keywords(s): Antibody, Cancer/Oncology, CAR T, Cell therapy, Gene therapy, Neurologic disease, Personalized medicine, Research tool, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Pharmacotherapy for Preventing Neurodegeneration
NU 2016-108
INVENTORS
D. James Surmeier*
Steven M. Graves
SHORT DESCRIPTION
Small molecule therapeutics to prevent neurological degeneration associated with other pharmaceutical treatments
ABSTRACT
Methamphetamine and amphetamine are pharmaceutical drugs sometimes used to treat attention definicity hyperactive disorder (ADHD), obesity, and narcolepsy....
Published: 11/6/2025
|
Inventor(s):
Keywords(s): Neurodegenerative disease, Neurologic disease, Obesity, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Infrared Tele-Video-Oculography for Remote Evaluation of Eye Movements
NU 2020-085
INVENTORS
Marcello Cherchi*
ABSTRACT
Observation of eye movements is essential in the diagnosis, monitoring and management of a broad range of vestibular disorders, that is diseases affecting balance. Ideally, this examination should be conducted so that the patient’s eye movements can be examined under specific circumstances: (1)...
Published: 11/6/2025
|
Inventor(s):
Keywords(s): Artificial Intelligence & Machine Learning, Bioinformatics, Computer software, COVID-19, Data processing/analysis, Devices, Neurologic disease, Ophthalmic disease, Remote Monitoring, Virtual Reality/Augmented Reality
Category(s): Life Sciences > Healthcare Devices, Tools & IT
|