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Covalent MEK4 Inhibitors for Targeted Cancer Therapy
NU 2025-154
INVENTORS
Karl Scheidt*
Gina Connors
SHORT DESCRIPTION
This technology introduces novel covalent inhibitors of MEK4, built upon previously-developed reversible inhibitors (see NU2019-059 and NU2021-217). A covalent inhibition strategy offers enhanced potency, selectivity, and prolonged duration of action compared to reversible...
Published: 12/16/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Covalent Inhibition, Kinase Inhibitor, Leukemia, MEK4, MEK7, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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