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Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169
INVENTORS
Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN))
Brian Meckes
Wuliang Zhang
SHORT DESCRIPTION
For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 11/7/2025
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Inventor(s):
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
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High-index Facet Nanocatalysts for Clean Energy Applications
NU2023-109
INVENTORS
Chad Mirkin*
Bo Shen
Zihao Ye
SHORT DESCRIPTION
A machine learning-guided, high-throughput DFT approach to synthesize high-index facet nanocatalysts with enhanced catalytic performance and broader material applicability.
BACKGROUND
Nanocrystals with high-index facets offer superior catalytic activity due to their abundance...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Catalyst, Cleantech, Materials, Metals, Nanomaterials, Nanoparticle
Category(s): Physical Sciences > Engineering & Technology
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Megalibrary Platform for Oxygen Evolution Reaction Catalysts
NU 2023-039
INVENTORS
Chad Mirkin*
Jin Huang
SHORT DESCRIPTION
A high-throughput nanoparticle megalibrary platform for discovering multielemental catalysts with enhanced activity and stability for oxygen evolution reactions in electrochemical energy systems.
BACKGROUND
The oxygen evolution reaction (OER) is a critical reaction in electrochemical...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Chemicals, Cleantech, Materials, Nanomaterials, Nanoparticle, Spectroscopy
Category(s): Physical Sciences > Materials and Industrial Processes
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Engineered Lipid Tags for Extracellular Vesicle Loading
NU 2022-178
INVENTORS
Neha Kamat*
Joshua Leonard*
Justin Alexander Peruzzi
Taylor Gunnels
SHORT DESCRIPTION
This technology enhances the loading of protein cargo into extracellular vesicles (EVs) by directing protein association with membrane lipid rafts, utilizing engineered lipid tags for targeted delivery.
BACKGROUND
Extracellular...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biotechnology, Drug delivery, Nanoparticle, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Leveraging Lipid-Protein Interactions to Engineer Spatial Organization in Cell-free Systems
NU 2021-231
INVENTORS
Neha Kamat*
Justin Alexander Peruzzi
Jan Steinkuehler
SHORT DESCRIPTION
This innovative method enables the control of membrane protein location and distribution in synthetic lipid membranes using lipid-protein interactions, without chemical conjugation, facilitating the development of advanced cell-free systems.
BACKGROUND
Spatially...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biotechnology, Drug delivery, Nanoparticle, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Physical Sciences > Engineering & Technology
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Magnetic-Lipid Nanocapsule (MLNC) – A novel nanoconstruct with high biocompatibility for theranostic applications
NU 2017-051
INVENTORS
Vinayak Dravid*
Vikas Nandwana
SHORT DESCRIPTION
A novel theranostic administrative nanoconstruct for non-invasive diagnostic Imaging and therapy.
BACKGROUND
Current applications for usage of magnetic nanostructures (MNS) are predominantly limited to disagnostic imaging as contrast agents. Lipid-based nanostructures are ideal...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Drug delivery, Nanoparticle, Therapeutics
Category(s): Life Sciences > Therapeutics
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Method to Synthesize Cement Reinforced with Multiwalled Carbon Nanotubes at Various High Concentration Levels
NU 2020-079
INVENTORS
Ange-Therese Akono*
Jiaxin Chen
ABSTRACT
Cement is one of the most popular construction materials in the world. Nanomaterials have come to play an important role due to the development of nanotechnology. Furthermore, cement nanocomposites have gained a lot of attention in recent years since nanomaterials bring extraordinary improvements...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Carbon nanotube, Materials, Nanoparticle
Category(s): Physical Sciences > Materials and Industrial Processes
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FIT-Flares for Detection of Intracellular Analytes in Live Cells
NU 2020-044
INVENTORS
Chad Mirkin*
Sasha Ebrahimi
Devleena Samanta
Ho Fung Cheng
SHORT DESCRIPTION
A new class of signaling aptamers which contain a single modification, yet can be used to detect a broad range of targets
ABSTRACT
Aptamers are oligonucleotide sequences that can be evolved to bind to various analytes of interest. Northwestern...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biomedical, Diagnostics, Nanoparticle, Research tool, Sensors
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Novel Nanocarriers for Improved Vaccine Efficacy and Production
NU 2019-066
INVENTORS
Dina Kats
Shaobin Shang
Chyung-Ru Wang
Evan A. Scott*
SHORT DESCRIPTION
A novel vaccine delivery system for enhanced immune response
BACKGROUND
In contrast to attenuated vaccines that contain live pathogens, subunit vaccines contain peptide antigens from a specific pathogen, enabling them to be produced more quickly...
Published: 11/6/2025
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Inventor(s):
Keywords(s): COVID-19, Nanoparticle, Therapeutics, Vaccine
Category(s): Life Sciences > Therapeutics
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Low-cost bactericidal and virucidal steel touch surfaces
NU 2020-087
INVENTORS
Yip-Wah Chung*
Q. Jane Wang*
Erica M. Hartmann*
Arman M. Khan
Seyon Vaynman
Dieter Isheim
SHORT DESCRIPTION
Novel copper-precipitation-strengthened steel for inexpensive bactericidal and virucidal surfaces
ABSTRACT
Northwestern researchers have developed novel low-carbon ferritic steels strengthened by nanometer-sized copper...
Published: 11/6/2025
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Inventor(s):
Keywords(s): COVID-19, Health & Safety, Materials, Metals, Nanomaterials, Nanoparticle, Transportation
Category(s): Physical Sciences > Materials and Industrial Processes
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