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Biomimetic HDL Nanoparticles for Treatment of Cancer, Immune and Inflammatory Disorders, and Cardiovascular Disease
SHORT DESCRIPTION
Self-assembling biomimetic high-density lipoprotein nanoparticle (HDL NP) platform technology with a soft organic core, designed to more closely replicate key functional properties of mature human HDL for therapeutic use in cardiovascular disease, cancer, and inflammatory/immune disorders.
INVENTORS
Colby Thaxton*
Northwestern...
Published: 7/1/2026
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Updated: 6/16/2026
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Inventor(s):
Keywords(s): Atherosclerosis, Autoimmune disease, BIO2026, Breast cancer, Cancer/Oncology, Cardiology and Cardiovascular disease, Gene therapy, Immunology, Immunotherapy, Inflammation, Nanomaterials, Nanoparticle, Nanotechnology, Nucleic Acids, Platform technology, Prostate cancer, Research tool, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
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Assembly of Vaccines Using Cell-Free Integration of Viral Membrane Proteins into Liposomes
SHORT DESCRIPTION
A cell-free method that assembles vaccines by integrating viral membrane proteins into liposomes, enabling rapid prototype production without cold chain requirements.
INVENTORS
Neha Kamat*
McCormick School of Engineering, Department of Biomedical Engineering
Hector Aguilar-Carreno
Susan...
Published: 6/16/2026
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Updated: 6/10/2026
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Inventor(s):
Keywords(s): BIO2026, Immunology, Infectious disease, Nanomaterials, Nanoparticle, Nanotechnology, Synthetic biology, Vaccine
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Targeted Nanoparticle-Mediated HIF Stabilization in Myeloid Cells for Enhanced Transplant Tolerance
SHORT DESCRIPTION
A PEG-PPS nanoparticle technology for targeted delivery of roxadustat to myeloid cells to promote transplantation tolerance.
INVENTORS
Edward Thorp*
Northwestern University Feinberg School of Medicine, Department of Pathology
Evan Scott*
McCormick School of Engineering, Department...
Published: 6/16/2026
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Updated: 5/7/2026
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Inventor(s):
Keywords(s): BIO2026, Drug delivery, Immunotherapy, Nanoparticle, Therapeutics, Tolerance induction, Transplantation
Category(s): Life Sciences > Therapeutics
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Northwestern Startup: NanoGraf
Founded: 2012
Northwestern Inventor:
Harold Kung
McCormick School of Engineering and Applied Science
Department of Chemical and Biological Engineering
Jiaxing Huang
McCormick School of Engineering and Applied Science
Department of Materials Science
Formerly SiNode Systems, NanoGraf pursues advances in Lithium-ion battery anodes to transform a wide...
Published: 6/22/2026
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Updated: 5/5/2026
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Inventor(s):
Keywords(s): Batteries, Energy and Infrastructure, Fuel Cell, Graphene, Nanoparticle, Startup with Northwestern IP, Sustainability, Sustainable Materials
Category(s): Physical Sciences > Energy & Sustainability, Physical Sciences > Materials and Industrial Processes
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Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets
SHORT DESCRIPTION
A targeted-protein degradation platform for intracellular targets, addressing resistant oncogenic and neurodegenerative targets.
INVENTORS
Shana Kelley*
Weinberg College of Arts & Sciences, Department of Chemistry
Yi Li
* Principal Investigator
NU Tech ID: NU 2025-050
IP...
Published: 6/16/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, BIO2026, Biologic, Biomolecular condensates, Cancer/Oncology, Drug delivery, Nanoparticle, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Platform technology, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Nano-therapeutics Targeting Cholesterol Efflux Transporter in Macrophages for Cancer Immunotherapy
NU 2025-160
INVENTORS
Jason Miska*
Feinberg School of Medicine, Department of Neurological Surgery
Peng Zhang*
Feinberg School of Medicine, Department of Neurological Surgery
SHORT DESCRIPTION
Novel nanoparticle technology that modulates macrophage cholesterol metabolism to boost anti-tumor immunity in GBM.
BACKGROUND
Glioblastoma...
Published: 6/16/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Adjunct therapy, BIO2026, Brain cancer, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunotherapy, Nanoparticle, Neurologic disease, Nucleic Acids, RNA - Ribonucleic Acid, Therapeutics
Category(s): Life Sciences > Therapeutics
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Bi-specific Lipid Nanoparticles for Boosting Antitumor Immunity in Glioblastoma
SHORT DESCRIPTION
A bispecific lipid nanoparticle that bridges tumor-associated myeloid cells (TAMCs) and glioma cells by dual checkpoint blockade and simultaneously reprograms TAMCs into antitumor effectors via targeted delivery of a STING agonist.
INVENTORS
Maciej Lesniak*
Northwestern University Feinberg School of Medicine,...
Published: 6/16/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): BIO2026, Brain cancer, Cancer/Oncology, Drug delivery, Immunotherapy, Nanoparticle, Nanotechnology, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Advanced Pulsed-Laser Synthesis for Metal Carbides
NU 2025-190
SHORT DESCRIPTION
A pulsed-laser synthesis method for making advanced metastable materials, including metal carbides and nitrides.
INVENTORS
Bryan Hunter*
Alexis Magana
Christopher Nowak
* Principal Investigator
NU 2025-190
IP STATUS
Provisional Application Filed (joint with Harvard University)
DEVELOPMENT...
Published: 4/22/2026
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Updated: 4/10/2026
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Inventor(s):
Keywords(s): Materials, Metals, Nanoparticle
Category(s): Physical Sciences > Materials and Industrial Processes
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Targeted pH Sensitive Liposomes
NU 2020-170
INVENTORS
Leo Gordon*
Dong-Hyun Kim*
Shuo Yang
Wooram Park
Taehoon Sim
SHORT DESCRIPTION
Liposomal nanoparticles composed of pH-sensitive lipids and apolipoprotein that encapsulate andrographolide for lymphoma treatment.
BACKGROUND
Lymphoma, particularly diffuse large B-cell lymphoma (DLBCL), is the most common aggressive type...
Published: 3/11/2026
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Updated: 3/11/2026
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Inventor(s):
Keywords(s): Blood & Lymphatic disease, Cancer/Oncology, Nanoparticle, Therapeutics
Category(s): Life Sciences > Therapeutics
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Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169
INVENTORS
Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN))
Brian Meckes
Wuliang Zhang
SHORT DESCRIPTION
For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 12/9/2025
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Updated: 10/30/2025
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Inventor(s):
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
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