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Targeted Nanoparticle-Mediated HIF Stabilization in Myeloid Cells for Enhanced Transplant Tolerance
SHORT DESCRIPTION
A PEG-PPS nanoparticle technology for targeted delivery of roxadustat to myeloid cells to promote transplantation tolerance.
INVENTORS
Edward Thorp*
Northwestern University Feinberg School of Medicine, Department of Pathology
Evan Scott*
McCormick School of Engineering, Department...
Published: 5/7/2026
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Updated: 5/7/2026
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Inventor(s):
Keywords(s): Drug delivery, Immunotherapy, Nanoparticle, Therapeutics, Tolerance induction, Transplantation
Category(s): Life Sciences > Therapeutics
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Northwestern Startup: NanoGraf
Founded: 2012Northwestern Inventor: Harold KungMcCormick School of Engineering and Applied ScienceDepartment of Chemical and Biological EngineeringJiaxing Huang McCormick School of Engineering and Applied ScienceDepartment of Materials ScienceFormerly SiNode Systems, NanoGraf pursues advances in Lithium-ion battery anodes to transform a wide range of...
Published: 5/5/2026
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Updated: 5/5/2026
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Inventor(s):
Keywords(s): Batteries, Energy and Infrastructure, Fuel Cell, Graphene, Nanoparticle, Startup with Northwestern IP, Sustainability, Sustainable Materials
Category(s): Physical Sciences > Energy & Sustainability, Physical Sciences > Materials and Industrial Processes
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Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets
SHORT DESCRIPTION
A targeted-protein degradation platform for intracellular targets, addressing resistant oncogenic and neurodegenerative targets.
INVENTORS
Shana Kelley*
Weinberg College of Arts & Sciences, Department of Chemistry
Yi Li
* Principal Investigator
NU Tech ID: NU 2025-050
IP...
Published: 5/7/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Biologic, Biomolecular condensates, Cancer/Oncology, Drug delivery, Nanoparticle, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Platform technology, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Nano-therapeutics Targeting Cholesterol Efflux Transporter in Macrophages for Cancer Immunotherapy
NU 2025-160
INVENTORS
Jason Miska*
Feinberg School of Medicine, Department of Neurological Surgery
Peng Zhang*
Feinberg School of Medicine, Department of Neurological Surgery
SHORT DESCRIPTION
Novel nanoparticle technology that modulates macrophage cholesterol metabolism to boost anti-tumor immunity in GBM.
BACKGROUND
Glioblastoma...
Published: 4/16/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Adjunct therapy, Brain cancer, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunotherapy, Nanoparticle, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Bi-specific Lipid Nanoparticles for Boosting Antitumor Immunity in Glioblastoma
SHORT DESCRIPTION
A bispecific lipid nanoparticle that bridges tumor-associated myeloid cells (TAMCs) and glioma cells by dual checkpoint blockade and simultaneously reprograms TAMCs into antitumor effectors via targeted delivery of a STING agonist.
INVENTORS
Maciej Lesniak*
Northwestern University Feinberg School of Medicine,...
Published: 4/30/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Brain cancer, Cancer/Oncology, Drug delivery, Immunotherapy, Nanoparticle, Nanotechnology, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Advanced Pulsed-Laser Synthesis for Metal Carbides
NU 2025-190
SHORT DESCRIPTION
A pulsed-laser synthesis method for making advanced metastable materials, including metal carbides and nitrides.
INVENTORS
Bryan Hunter*
Alexis Magana
Christopher Nowak
* Principal Investigator
NU 2025-190
IP STATUS
Provisional Application Filed (joint with Harvard University)
DEVELOPMENT...
Published: 4/22/2026
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Updated: 4/10/2026
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Inventor(s):
Keywords(s): Materials, Metals, Nanoparticle
Category(s): Physical Sciences > Materials and Industrial Processes
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Targeted pH Sensitive Liposomes
NU 2020-170
INVENTORS
Leo Gordon*
Dong-Hyun Kim*
Shuo Yang
Wooram Park
Taehoon Sim
SHORT DESCRIPTION
Liposomal nanoparticles composed of pH-sensitive lipids and apolipoprotein that encapsulate andrographolide for lymphoma treatment.
BACKGROUND
Lymphoma, particularly diffuse large B-cell lymphoma (DLBCL), is the most common aggressive type...
Published: 3/11/2026
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Updated: 3/11/2026
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Inventor(s):
Keywords(s): Blood & Lymphatic disease, Cancer/Oncology, Nanoparticle, Therapeutics
Category(s): Life Sciences > Therapeutics
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Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169
INVENTORS
Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN))
Brian Meckes
Wuliang Zhang
SHORT DESCRIPTION
For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 12/9/2025
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Updated: 10/30/2025
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Inventor(s):
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
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High-index Facet Nanocatalysts for Clean Energy Applications
NU2023-109
INVENTORS
Chad Mirkin*
Bo Shen
Zihao Ye
SHORT DESCRIPTION
A machine learning-guided, high-throughput DFT approach to synthesize high-index facet nanocatalysts with enhanced catalytic performance and broader material applicability.
BACKGROUND
Nanocrystals with high-index facets offer superior catalytic activity due to their abundance...
Published: 11/6/2025
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Updated: 7/16/2025
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Inventor(s):
Keywords(s): Catalyst, Cleantech, Materials, Metals, Nanomaterials, Nanoparticle
Category(s): Physical Sciences > Engineering & Technology
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Megalibrary Platform for Oxygen Evolution Reaction Catalysts
NU 2023-039
INVENTORS
Chad Mirkin*
Jin Huang
SHORT DESCRIPTION
A high-throughput nanoparticle megalibrary platform for discovering multielemental catalysts with enhanced activity and stability for oxygen evolution reactions in electrochemical energy systems.
BACKGROUND
The oxygen evolution reaction (OER) is a critical reaction in electrochemical...
Published: 11/6/2025
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Updated: 7/16/2025
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Inventor(s):
Keywords(s): Chemicals, Cleantech, Materials, Nanomaterials, Nanoparticle, Spectroscopy
Category(s): Physical Sciences > Materials and Industrial Processes
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