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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION
Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma.
INVENTORS
Amy Heimberger*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
* Principal Investigator
NU 2025-212
IP STATUS
US...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunology, Immunotherapy, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Mitigating aberrant Cdk5 Activation in SMA – A Novel Therapeutic Strategy Targeting Mitochondrial Function
SHORT DESCRIPTION
A targeted strategy that mitigates aberrant Cdk5 activity to restore mitochondrial function and reduce motor neuron degeneration in SMA models.
INVENTORS
Yongchao Ma*
Northwestern University Feinberg School of Medicine, Department of Pediatrics
* Principal Investigator
NU Tech...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): Adjunct therapy, Neurodegenerative disease, Neurologic disease, Neurology, Rare diseases, SMA - Spinal muscular atrophy, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Nano-therapeutics Targeting Cholesterol Efflux Transporter in Macrophages for Cancer Immunotherapy
NU 2025-160
INVENTORS
Jason Miska*
Feinberg School of Medicine, Department of Neurological Surgery
Peng Zhang*
Feinberg School of Medicine, Department of Neurological Surgery
SHORT DESCRIPTION
Novel nanoparticle technology that modulates macrophage cholesterol metabolism to boost anti-tumor immunity in GBM.
BACKGROUND
Glioblastoma...
Published: 4/16/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Adjunct therapy, Brain cancer, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunotherapy, Nanoparticle, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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TGF-beta Inhibitor for Reversing HIV Latency
NU 2022-207
INVENTORS
Elena Martinelli*
SHORT DESCRIPTION
A method for activating latent immunodeficiency virus infections using a TGF-beta inhibitor in order to treat HIV.
BACKGROUND
Current HIV treatments focus on inhibiting viral replication but fail to address latent HIV reservoirs, which pose a risk of reactivation and disease progression....
Published: 4/13/2026
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Updated: 2/17/2025
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Inventor(s):
Keywords(s): Adjunct therapy, Infectious disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Anti-PODXL Antibody for Inhibiting Metastasis in Breast Cancer
NU 2023-110
INVENTORS
Huiping Liu*
Nurmaa Dashzeveg
SHORT DESCRIPTION
This technology introduces methods of use for an anti-PODXL antibody that effectively prevents and treats metastasis in breast cancer by inhibiting circulating tumor cell (CTC) cluster formation.
BACKGROUND
Cancer metastasis is mediated by circulating tumor cells (CTC) and...
Published: 4/13/2026
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Updated: 1/28/2025
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Inventor(s):
Keywords(s): Adjunct therapy, Antibody, Biologic, Breast cancer, Cancer/Oncology, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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