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Novel 2-Imidazolyl-Pyrimidine Inhibitors for Neurodegenerative Disease Therapeutics
NU 2014-101
INVENTORS
Richard Silverman*
Paramita Mukherjee
SHORT DESCRIPTION
This invention introduces novel 2-imidazolyl-pyrimidine scaffolds that inhibit neuronal nitric oxide synthase. It offers potential for drug development targeting Parkinson’s and other neurodegenerative diseases.
BACKGROUND
Neurodegenerative disorders such as...
Published: 12/3/2025
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Inventor(s):
Keywords(s): Biomedical, Materials, Neurodegenerative disease, Neurologic disease, Neurology, Small molecule, Therapeutics
Category(s): Physical Sciences > Materials and Industrial Processes
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Potent and selective Cav1.3 negative allosteric modulators for use in Parkinson's Disease
NU 2010-105 and NU 2024-179
INVENTORS
Richard Silverman* (Northwestern University, Weinberg College of Arts & Science, Department of Chemistry)
Dalton Surmeier Jr.* (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience)
Garry Cooper
Soosung Kang
Jack Nguyen
SHORT DESCRIPTION
For pharmaceutical...
Published: 11/11/2025
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Inventor(s):
Keywords(s): Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
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Intraoperative Neuromuscular Monitoring via Soft, Skin-Mounted Wireless Devices
NU 2017-108
INVENTORS
John Rogers*
SHORT DESCRIPTION
This technology introduces a soft, wireless, skin-mounted device that enables non-invasive, real-time monitoring of neuromuscular function during surgical procedures, reducing patient discomfort and procedural complexity.
BACKGROUND
Conventional intraoperative neuromuscular monitoring relies...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Devices, Health IT, Medical device, Neurology
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Printed Volatile Memristors for Neuromorphic Computing Hardware
NU 2025-007
INVENTORS
Mark Hersam*
Shreyash Hadke
Vinod Sangwan
SHORT DESCRIPTION
This technology involves the development of printed volatile memristors designed for neuromorphic computing hardware. These memristors can be printed on flexible substrates, and mimic the complex spiking behavior of biological neurons.
BACKGROUND
Neuromorphic...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Neurology, Printed electronics
Category(s): Physical Sciences > Materials and Industrial Processes
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Artificial Extracellular Matrix for Enhanced Maturation of Human iPSCs-derived Neurons
Artificial Extracellular Matrix for Enhanced Maturation of Human iPSCs-derived Neurons
NU 2018-157
Peptide amphiphile nanofibers enhance neuron maturation by promoting high mobility while reducing cell aggregation.
INVENTORS
Samuel I. Stupp
Zaida Alvarez Pinto
Juan Alberto Ortega Cano
Kohei Sato
Evangelos Kiskinis
SHORT DESCRIPTION
A...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Neurology, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Cell-type specific disruption of M1 muscarinic acetylcholine receptor expression to alleviate Parkinson's disease
NU 2024-244
INVENTORS
Dalton J. Surmeier Jr*
Tatiana Tkatch
Shenyu Zhai
SHORT DESCRIPTION
Gene therapy targeting M1 muscarinic receptor expression in striatal spiny projection neurons to enhance levodopa response and slow Parkinson’s Disease progression.
BACKGROUND
Parkinson’s Disease (PD) is the second most common age-related...
Published: 1/5/2026
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Inventor(s):
Keywords(s): CNS - Central Nervous System, Gene therapy, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Gene therapy for levodopa-induced dyskinesia
NU 2024-086
INVENTORS
Dalton J. Surmeier Jr*
Weixing Shen
Shenyu Zhai
Tatiana Tkatch
Qiaoling Cui
Zhong Xie
SHORT DESCRIPTION
Gene therapy targeting GRIN2B in striatal spiny projection neurons to treat levodopa-induced dyskinesia.
BACKGROUND
Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease...
Published: 1/5/2026
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Inventor(s):
Keywords(s): CNS - Central Nervous System, Dyskinesis, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Collagen IV binding Vascular Endothelial Growth Factor (VEGF) Bioconjugates for Vascularization
NU2022-150
INVENTORS
Kyle M. Koss*
Yangxi Liu
Jason A. Wertheim*
SHORT DESCRIPTION
Bioconjugates that localize and concentrate VEGF within scaffold structures to support long-term cell survival and promote vascularization in tissue engineering applications
BACKGROUND
The development of effective vascularization strategies is crucial for...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Hematology, Neurology
Category(s): Life Sciences > Therapeutics
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Therapeutic Intervention for ALS and Dementia
NU 2021-058
INVENTORS
Evangelos Kiskinis*
Juan Alberto Ortega Cano Marco Boccitto
SHORT DESCRIPTION
Design of an RNA-based oligonucleotide that protects from dipeptide repeat protein toxicity for the treatment of ALS and FTD.
BACKGROUND
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative diseases...
Published: 12/18/2025
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Inventor(s):
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, CNS - Central Nervous System, DPR - Dipeptide Repeat Proteins, FTD - Frontotemporal Dementia, Neurodegenerative disease, Neurology, RNA - Ribonucleic Acid, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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A CSF-derived therapy for psychiatric disorders
NU2023-196
INVENTORS
Peter Penzes*
Marc Dos Santos
BACKGROUND
Currently, there is a lack of treatments which address the negative and cognitive symptoms of psychiatric disorders such as schizophrenia. Northwestern researchers have designed a recombinant form of ⍺2d-1 protein, a subunit of the voltage-gated calcium channel, to restore protein...
Published: 12/23/2025
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Inventor(s):
Keywords(s): Biologic, Neurologic disease, Neurology, PSD - Psychotic spectrum disorder, Psychiatric disease, Schizophrenia, Therapeutics
Category(s): Life Sciences > Therapeutics
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