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Novel 2-Imidazolyl-Pyrimidine Inhibitors for Neurodegenerative Disease Therapeutics
NU 2014-101
INVENTORS
Richard Silverman*
Paramita Mukherjee
SHORT DESCRIPTION
This invention introduces novel 2-imidazolyl-pyrimidine scaffolds that inhibit neuronal nitric oxide synthase. It offers potential for drug development targeting Parkinson’s and other neurodegenerative diseases.
BACKGROUND
Neurodegenerative disorders such as...
Published: 12/3/2025
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Inventor(s):
Keywords(s): Biomedical, Materials, Neurodegenerative disease, Neurologic disease, Neurology, Small molecule, Therapeutics
Category(s): Physical Sciences > Materials and Industrial Processes
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Potent and selective Cav1.3 negative allosteric modulators for use in Parkinson's Disease
NU 2010-105 and NU 2024-179
INVENTORS
Richard Silverman* (Northwestern University, Weinberg College of Arts & Science, Department of Chemistry)
Dalton Surmeier Jr.* (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience)
Garry Cooper
Soosung Kang
Jack Nguyen
SHORT DESCRIPTION
For pharmaceutical...
Published: 11/11/2025
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Inventor(s):
Keywords(s): Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
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TauSeeK: Disease Specific Tau Protein Fibrils & Seeding Proteins
NU 2024-154
INVENTORS
Songi Han*
Austin Dubose
Michael Vigers
Andrew Longhini
Vishnu Vijayan
Kenneth Kosik
Samuel Lobo
Peter C. Ryffel
Lokeswara Rao Potnuru
Karen Tsay
Chung-Ta Han
SHORT DESCRIPTION
Compositions, kits, and methods for generating synthetic miniature tau peptides and fibrils, and synthetic full-length pathogenic tau...
Published: 1/14/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, HD - Huntington's Disease, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Research tool
Category(s): Life Sciences > Therapeutics
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Methods for assembling peptides into peptide amphiphile nanofibers
TITLE: Peptide Nanofiber Assembly for Enhanced Therapeutic Delivery
NU 2020-081
SHORT DESCRIPTION
This technology uses self-assembling peptide amphiphile nanofibers to protect and deliver therapeutic peptides. It reduces degradation and improves delivery efficiency for advanced treatment applications.
BACKGROUND
Peptide therapeutics offer promise...
Published: 1/9/2026
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Inventor(s):
Keywords(s): Brain injury, Drug delivery, Infectious disease, Nanomaterials, Neurodegenerative disease, Neurologic disease, Neurology, Neurovascular, Therapeutics
Category(s): Life Sciences > Therapeutics
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Intraoperative Neuromuscular Monitoring via Soft, Skin-Mounted Wireless Devices
NU 2017-108
INVENTORS
John Rogers*
SHORT DESCRIPTION
This technology introduces a soft, wireless, skin-mounted device that enables non-invasive, real-time monitoring of neuromuscular function during surgical procedures, reducing patient discomfort and procedural complexity.
BACKGROUND
Conventional intraoperative neuromuscular monitoring relies...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Devices, Health IT, Medical device, Neurology
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Sliding Bioactive Peptides for Therapeutic Delivery
NU 2023-142
INVENTORS
Samuel I. Stupp*
Federico Lancia
Madison E. Strong
Matias A. Alvarez-Saavedra
SHORT DESCRIPTION
This technology involves the design and engineering of peptide amphiphile nanofibers that deliver bioactive peptides both extra- and intra-cellularly. The bioactive peptides can slide along these structures...
Published: 1/9/2026
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Inventor(s):
Keywords(s): Biomaterials, CNS - Central Nervous System, Drug delivery, Neurologic disease, Neurology, Regenerative medicine, SCI - Spinal cord injury, Therapeutics
Category(s): Life Sciences > Therapeutics
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Printed Volatile Memristors for Neuromorphic Computing Hardware
NU 2025-007
INVENTORS
Mark Hersam*
Shreyash Hadke
Vinod Sangwan
SHORT DESCRIPTION
This technology involves the development of printed volatile memristors designed for neuromorphic computing hardware. These memristors can be printed on flexible substrates, and mimic the complex spiking behavior of biological neurons.
BACKGROUND
Neuromorphic...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Neurology, Printed electronics
Category(s): Physical Sciences > Materials and Industrial Processes
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Artificial Extracellular Matrix for Enhanced Maturation of Human iPSCs-derived Neurons
Artificial Extracellular Matrix for Enhanced Maturation of Human iPSCs-derived Neurons
NU 2018-157
Peptide amphiphile nanofibers enhance neuron maturation by promoting high mobility while reducing cell aggregation.
INVENTORS
Samuel I. Stupp
Zaida Alvarez Pinto
Juan Alberto Ortega Cano
Kohei Sato
Evangelos Kiskinis
SHORT DESCRIPTION
A...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Neurology, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Cell-type specific disruption of M1 muscarinic acetylcholine receptor expression to alleviate Parkinson's disease
NU 2024-244
INVENTORS
Dalton J. Surmeier Jr*
Tatiana Tkatch
Shenyu Zhai
SHORT DESCRIPTION
Gene therapy targeting M1 muscarinic receptor expression in striatal spiny projection neurons to enhance levodopa response and slow Parkinson’s Disease progression.
BACKGROUND
Parkinson’s Disease (PD) is the second most common age-related...
Published: 1/5/2026
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Inventor(s):
Keywords(s): CNS - Central Nervous System, Gene therapy, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Gene therapy for levodopa-induced dyskinesia
NU 2024-086
INVENTORS
Dalton J. Surmeier Jr*
Weixing Shen
Shenyu Zhai
Tatiana Tkatch
Qiaoling Cui
Zhong Xie
SHORT DESCRIPTION
Gene therapy targeting GRIN2B in striatal spiny projection neurons to treat levodopa-induced dyskinesia.
BACKGROUND
Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease...
Published: 1/5/2026
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Inventor(s):
Keywords(s): CNS - Central Nervous System, Dyskinesis, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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