|
A Biosensor Engineering Strategy for Improved Cell-based Therapy
NU 2016-174
Inventors
Joshua N. Leonard*
Kelly A. Schwarz
Rachel M. Dudek
Short Description
A sophisticated multiplexed biosensor system that can activate a downstream promoter to effect diverse custom biological functions. #therapeutics #cellsignaling #healthcare #diagnostictool
Background
The market for cell-based therapeutics has gained wide...
Published: 5/12/2026
|
Updated: 5/12/2026
|
Inventor(s):
Keywords(s): Biotechnology, Cell therapy, Research tool, Sensors, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
|
|
Orthogonal Synthetic Receptors for IL-23
SHORT DESCRIPTION
Synthetic IL-23 receptors for cell engineering to enable real-time sensing and drive precise autoimmune and cancer immunotherapy interventions.
INVENTORS
Joshua Leonard*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Aaron Morris
William Corcoran
...
Published: 5/8/2026
|
Updated: 4/14/2026
|
Inventor(s):
Keywords(s): Autoimmune disease, Cell engineering, Cell therapy, Diagnostics, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
|
|
Responsive Probiotic Therapy for Local Detection and Treatment of IBD Flares
SHORT DESCRIPTION
An engineered probiotic that senses intestinal inflammation via calprotectin and locally releases therapeutic antibodies in the gastrointestinal tract only during inflammatory flares.
INVENTORS
Arthur Prindle*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Jonathan...
Published: 5/11/2026
|
Updated: 4/14/2026
|
Inventor(s):
Keywords(s): Autoimmune disease, Biologic, Cell therapy, Diagnostics, Gastrointestinal and Hepatic disease, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Synthetic biology, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Engineered B-cell Therapy for Cancer Treatment
NU 2022-218
INVENTORS
Catalina Lee Chang*
Maciej Lesniak*
SHORT DESCRIPTION
Engineered B cells with reduced expression of key immune checkpoint proteins designed to boost cancer immunotherapy efficacy.
BACKGROUND
Immunotherapy has transformed cancer treatment; however, its application to brain tumors remains limited by the immunosuppressive...
Published: 4/8/2026
|
Updated: 12/3/2025
|
Inventor(s):
Keywords(s): Cancer/Oncology, Cell therapy, Immunotherapy, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Compositions and Methods for the Treatment of Intestinal Inflammation
NU 2021-252
INVENTORS
Matthew Bury
Muthukumar Gunasekaran
Sunjay Kaushal
Arun Sharma*
Tiffany Sharma
BACKGROUND
Crohn’s Disease (CD) is partly caused by a highly pro-inflammatory lesion microenvironment which subsequently causes numerous clinical complications. Northwestern University scientists have developed a method to control...
Published: 3/17/2026
|
Updated: 2/25/2025
|
Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Cell therapy, IBD - Inflammatory bowel disease, Immunotherapy, Infectious disease, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
CAR T Cells Armored with IL15 for Treating Glioblastoma
NU 2022-074
INVENTORS
Irina V. Balyasnikova*
BACKGROUND
Glioblastoma is a devastating brain cancer for which no effective treatment exists, leading to short patient survival. Although investigations are underway to explore chimeric antigen receptor T (CAR-T) cells as glioblastoma therapy, the immunosuppressive tumor microenvironment (TME)...
Published: 4/9/2026
|
Updated: 10/17/2024
|
Inventor(s):
Keywords(s): Brain cancer, Cancer/Oncology, Cell therapy, Immunology, Immunotherapy, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Humanized antibody targeting the tumor associated antigen, IL13Ra2
Humanized antibody targeting the tumor associated antigen, IL13Ra2
NU 2020-031
INVENTORS
Irina Balyasnikova*
SHORT DESCRIPTION
A novel antibody that specifically targets glioblastoma cells
BACKGROUND
Glioblastoma is a deadly, incurable disease with a low 5 year survival rate. The current standard of care typically involves surgical resection...
Published: 3/5/2026
|
Updated: 6/1/2023
|
Inventor(s):
Keywords(s): Antibody, Cancer/Oncology, CAR T, Cell therapy, Gene therapy, Neurologic disease, Personalized medicine, Research tool, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Escherichia coli From Human Prostate
NU 2010-012 Inventors Praveen Thumbikat Anthony Schaeffer* Short Description Novel bacterial strain for research of chronic pelvic painAbstract Northwestern researchers have discovered uropathogenic Escherichia coli (UPEC) that causes chronic prostatitis/chronic pelvic pain (CP/CPP). Despite an urgent need for a greater understanding of this disease,...
Published: 3/25/2026
|
Updated: 2/12/2019
|
Inventor(s):
Keywords(s): Cell therapy, Chronic pain, Research tool, Therapeutics, Urology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
|