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Engineered B-cell Therapy for Cancer Treatment
NU 2022-218
INVENTORS
Catalina Lee Chang*
Maciej Lesniak*
SHORT DESCRIPTION
Engineered B cells with reduced expression of key immune checkpoint proteins designed to boost cancer immunotherapy efficacy.
BACKGROUND
Immunotherapy has transformed cancer treatment; however, its application to brain tumors remains limited by the immunosuppressive...
Published: 4/8/2026
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Updated: 12/3/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Cell therapy, Immunotherapy, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Compositions and Methods for the Treatment of Intestinal Inflammation
NU 2021-252
INVENTORS
Matthew Bury
Muthukumar Gunasekaran
Sunjay Kaushal
Arun Sharma*
Tiffany Sharma
BACKGROUND
Crohn’s Disease (CD) is partly caused by a highly pro-inflammatory lesion microenvironment which subsequently causes numerous clinical complications. Northwestern University scientists have developed a method to control...
Published: 3/17/2026
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Updated: 2/25/2025
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Cell therapy, IBD - Inflammatory bowel disease, Immunotherapy, Infectious disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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CAR T Cells Armored with IL15 for Treating Glioblastoma
NU 2022-074
INVENTORS
Irina V. Balyasnikova*
BACKGROUND
Glioblastoma is a devastating brain cancer for which no effective treatment exists, leading to short patient survival. Although investigations are underway to explore chimeric antigen receptor T (CAR-T) cells as glioblastoma therapy, the immunosuppressive tumor microenvironment (TME)...
Published: 4/9/2026
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Updated: 10/17/2024
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Inventor(s):
Keywords(s): Brain cancer, Cancer/Oncology, Cell therapy, Immunology, Immunotherapy, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Humanized antibody targeting the tumor associated antigen, IL13Ra2
Humanized antibody targeting the tumor associated antigen, IL13Ra2
NU 2020-031
INVENTORS
Irina Balyasnikova*
SHORT DESCRIPTION
A novel antibody that specifically targets glioblastoma cells
BACKGROUND
Glioblastoma is a deadly, incurable disease with a low 5 year survival rate. The current standard of care typically involves surgical resection...
Published: 3/5/2026
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Updated: 6/1/2023
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Inventor(s):
Keywords(s): Antibody, Cancer/Oncology, CAR T, Cell therapy, Gene therapy, Neurologic disease, Personalized medicine, Research tool, Therapeutics
Category(s): Life Sciences > Therapeutics
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Escherichia coli From Human Prostate
NU 2010-012 Inventors Praveen Thumbikat Anthony Schaeffer* Short Description Novel bacterial strain for research of chronic pelvic painAbstract Northwestern researchers have discovered uropathogenic Escherichia coli (UPEC) that causes chronic prostatitis/chronic pelvic pain (CP/CPP). Despite an urgent need for a greater understanding of this disease,...
Published: 3/25/2026
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Updated: 2/12/2019
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Inventor(s):
Keywords(s): Cell therapy, Chronic pain, Research tool, Therapeutics, Urology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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