|
Targeting Autoimmunity-Associated T cells via AHR Pathway Control
SHORT DESCRIPTION
Use of AHR agonists to inhibit pathogenic Tfh/Tph cell differentiation, potentially reducing disease activity.
INVENTORS
Jaehyuk Choi*
Northwestern University Feinberg School of Medicine, Department of Dermatology **(Now at UT Southwestern)**
Deepak Rao
Brigham and Women's...
Published: 5/7/2026
|
Updated: 5/7/2026
|
Inventor(s):
Keywords(s): Autoimmune disease, Immunology, Immunotherapy, Inflammation, RA - Rheumatoid arthritis, SLE - Systemic lupus erythematosus, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Once-Weekly Glucocorticoid Steroid Dosing for Enhanced Muscle Function and Metabolic Health
SHORT DESCRIPTION
A glucocorticoid regimen that preserves the benefits of steroids on muscle mass and function while mitigating many of the metabolic and growth‑related toxicities seen with daily dosing in various inflammatory, autoimmune, respiratory, and neuromuscular disease settings.
INVENTORS
Elizabeth McNally*, MD, PhD
Northwestern...
Published: 5/11/2026
|
Updated: 5/7/2026
|
Inventor(s):
Keywords(s): Aging, DMD - Duchenne muscular dystrophy, Immunology, Inflammation, Metabolic disorders, Muscle metabolism, Rare diseases, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION
Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma.
INVENTORS
Amy Heimberger*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
* Principal Investigator
NU Tech ID: NU 2025-212
IP...
Published: 5/7/2026
|
Updated: 4/27/2026
|
Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
|
|
Drug Repurposing for Age-Impaired Vascular Repair in COVID-19, Sepsis, and ARDS
SHORT DESCRIPTION
Methods and compositions for treating COVID-19, sepsis, acute respiratory distress syndrome (ARDS), and cardiovascular diseases in elderly patients by either inhibiting vascular endothelial injury/inflammation or promoting FOXM1-dependent endothelial regeneration and vascular repair.
INVENTORS
Youyang Zhao
Northwestern...
Published: 5/8/2026
|
Updated: 4/22/2026
|
Inventor(s):
Keywords(s): ARDS - Acute Respiratory Distress Syndrome, COVID-19, Immunology, Infectious disease, Inflammation, Pulmonary disease, Therapeutics, Vascular disease, Vascular repair
Category(s): Life Sciences > Therapeutics
|
|
Orthogonal Synthetic Receptors for IL-23
SHORT DESCRIPTION
Synthetic IL-23 receptors for cell engineering to enable real-time sensing and drive precise autoimmune and cancer immunotherapy interventions.
INVENTORS
Joshua Leonard*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Aaron Morris
William Corcoran
...
Published: 5/8/2026
|
Updated: 4/14/2026
|
Inventor(s):
Keywords(s): Autoimmune disease, Cell engineering, Cell therapy, Diagnostics, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
|
|
Responsive Probiotic Therapy for Local Detection and Treatment of IBD Flares
SHORT DESCRIPTION
An engineered probiotic that senses intestinal inflammation via calprotectin and locally releases therapeutic antibodies in the gastrointestinal tract only during inflammatory flares.
INVENTORS
Arthur Prindle*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Jonathan...
Published: 5/11/2026
|
Updated: 4/14/2026
|
Inventor(s):
Keywords(s): Autoimmune disease, Biologic, Cell therapy, Diagnostics, Gastrointestinal and Hepatic disease, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Synthetic biology, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and neurodegenerative disorders
NU 2025-113 (NU 2016-137, NU 2018-176, NU 2019-179, NU 2023-007, NU 2024-250, NU 2025-038)
INVENTORS
Richard Silverman
Weinberg College of Arts and Sciences, Department of Chemistry
SHORT DESCRIPTION
Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and other cancers with high expression...
Published: 5/21/2026
|
Updated: 4/1/2026
|
Inventor(s):
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, AUTM26C1, BIAUTM1, Cancer/Oncology, Cardiology and Cardiovascular disease, Immunodeficiency, Immunology, Immunotherapy, Melanoma, Neurodegenerative disease, Neuroinflammation, nNOS, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
A Rat Model of IgA Nephropathy
NU 2019-196
INVENTORS
Jing Jin*
Xinfang Xie
SHORT DESCRIPTION
A novel rat model of IgA nephropathy (IgAN, also known as Berger's disease), enabling reproducible kidney mesangial deposits characteristic of the human disease for therapeutic and diagnostic evaluation.
BACKGROUND
IgAN, the most common glomerulonephritis worldwide, results...
Published: 4/13/2026
|
Updated: 2/26/2026
|
Inventor(s):
Keywords(s): Animal Model, Antibody, Drug screening, Immunology, Inflammation, Renal Disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
|
|
A platform for mapping reactive cysteines within the immunopeptidome
NU 2024-044
INVENTORS
Xiaoyu Zhang*
Chenlu Zhang
Chen Zhou
SHORT DESCRIPTION
This invention provides novel chemical probes for mapping reactive cysteine residues within the major histocompatibility complex class I (MHC-I) immunopeptidome.
BACKGROUND
The immune system's recognition of infected or malignant cells hinges on the presentation...
Published: 12/11/2025
|
Updated: 10/31/2025
|
Inventor(s):
Keywords(s): Biomarker, Immunology, Research reagent, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
|
|
Assembly of Vaccines Using Cell-Free Integration of Viral Membrane Proteins into Liposomes
NU 2022-192
INVENTORS
Neha P. Kamat*
Vivian Hu
BACKGROUND
Virus infection posts a recurring global health challenge, and vaccines remain an effective protective against virus threats. However, many current vaccines face limitations including potential conversion of inactivated virus into pathogenic virus, immunogenicity of recombinant...
Published: 4/10/2026
|
Updated: 10/17/2024
|
Inventor(s):
Keywords(s): Immunology, Infectious disease, Nanomaterials, Nanoparticle, Nanotechnology, Synthetic biology, Vaccine
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
|