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Peptide Linkers for Modulating Antigen Immune Response in Cancer Vaccines
SHORT DESCRIPTION
A novel non-biologically derived peptide linker technology enabling precise intracellular release of vaccine antigens to enhance immune activation.
NU TECH ID
NU 2024-124
INVENTORS
Chad Mirkin*
Weinberg College of Arts and Sciences, Department of Chemistry
Tanner Fink
*...
Published: 6/16/2026
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Updated: 6/16/2026
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Inventor(s):
Keywords(s): BIO2026, Cancer/Oncology, Immunology, Immunotherapy, Infectious disease, Therapeutics, Vaccine
Category(s): Life Sciences > Therapeutics
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Biomimetic HDL Nanoparticles for Treatment of Cancer, Immune and Inflammatory Disorders, and Cardiovascular Disease
SHORT DESCRIPTION
Self-assembling biomimetic high-density lipoprotein nanoparticle (HDL NP) platform technology with a soft organic core, designed to more closely replicate key functional properties of mature human HDL for therapeutic use in cardiovascular disease, cancer, and inflammatory/immune disorders.
INVENTORS
Colby Thaxton*
Northwestern...
Published: 7/1/2026
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Updated: 6/16/2026
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Inventor(s):
Keywords(s): Atherosclerosis, Autoimmune disease, BIO2026, Breast cancer, Cancer/Oncology, Cardiology and Cardiovascular disease, Gene therapy, Immunology, Immunotherapy, Inflammation, Nanomaterials, Nanoparticle, Nanotechnology, Nucleic Acids, Platform technology, Prostate cancer, Research tool, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
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Retargetable and Metabolically Tunable CAR Cell Platforms for Durable, Antigen‑Specific Cancer Therapy
SHORT DESCRIPTION
A modular immunotherapy platform that combines hapten‑redirectable chimeric antigen receptor (CAR) constructs with itaconate‑programmed, memory‑like immune cells to deliver safer, more durable, and tunable antigen‑specific responses across hematologic and solid tumors.
NU TECH ID
NU 2023-021B
INVENTORS
Ashima...
Published: 7/8/2026
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Updated: 6/10/2026
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Inventor(s):
Keywords(s): Autoimmune disease, Cancer Treatment, Cancer/Oncology, Cell therapy, Immunology, Immunotherapy, Inflammation, Leukemia, Lymphoma, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Assembly of Vaccines Using Cell-Free Integration of Viral Membrane Proteins into Liposomes
SHORT DESCRIPTION
A cell-free method that assembles vaccines by integrating viral membrane proteins into liposomes, enabling rapid prototype production without cold chain requirements.
INVENTORS
Neha Kamat*
McCormick School of Engineering, Department of Biomedical Engineering
Hector Aguilar-Carreno
Susan...
Published: 6/16/2026
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Updated: 6/10/2026
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Inventor(s):
Keywords(s): BIO2026, Immunology, Infectious disease, Nanomaterials, Nanoparticle, Nanotechnology, Synthetic biology, Vaccine
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Targeting Autoimmunity-Associated T cells via AHR Pathway Control
SHORT DESCRIPTION
Use of AHR agonists to inhibit pathogenic Tfh/Tph cell differentiation, potentially reducing disease activity.
INVENTORS
Jaehyuk Choi*
Northwestern University Feinberg School of Medicine, Department of Dermatology **(Now at UT Southwestern)**
Deepak Rao
Brigham and Women's...
Published: 6/16/2026
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Updated: 5/7/2026
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Inventor(s):
Keywords(s): Autoimmune disease, BIO2026, Immunology, Immunotherapy, Inflammation, RA - Rheumatoid arthritis, SLE - Systemic lupus erythematosus, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Once-Weekly Glucocorticoid Steroid Dosing for Enhanced Muscle Function and Metabolic Health
SHORT DESCRIPTION
A glucocorticoid regimen that preserves the benefits of steroids on muscle mass and function while mitigating many of the metabolic and growth‑related toxicities seen with daily dosing in various inflammatory, autoimmune, respiratory, and neuromuscular disease settings.
INVENTORS
Elizabeth McNally*, MD, PhD
Northwestern...
Published: 6/16/2026
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Updated: 5/7/2026
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Inventor(s):
Keywords(s): Aging, BIO2026, DMD - Duchenne muscular dystrophy, Immunology, Inflammation, Metabolic disorders, Muscle metabolism, Rare diseases, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION
Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma.
INVENTORS
Amy Heimberger*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
* Principal Investigator
NU Tech ID: NU 2025-212
IP...
Published: 6/16/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, BIO2026, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Drug Repurposing for Age-Impaired Vascular Repair in COVID-19, Sepsis, and ARDS
SHORT DESCRIPTION
Methods and compositions for treating COVID-19, sepsis, acute respiratory distress syndrome (ARDS), and cardiovascular diseases in elderly patients by either inhibiting vascular endothelial injury/inflammation or promoting FOXM1-dependent endothelial regeneration and vascular repair.
INVENTORS
Youyang Zhao
Northwestern...
Published: 6/16/2026
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Updated: 4/22/2026
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Inventor(s):
Keywords(s): ARDS - Acute Respiratory Distress Syndrome, BIO2026, COVID-19, Immunology, Infectious disease, Inflammation, Pulmonary disease, Therapeutics, Vascular disease, Vascular repair
Category(s): Life Sciences > Therapeutics
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Orthogonal Synthetic Receptors for IL-23
SHORT DESCRIPTION
Synthetic IL-23 receptors for cell engineering to enable real-time sensing and drive precise autoimmune and cancer immunotherapy interventions.
INVENTORS
Joshua Leonard*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Aaron Morris
William Corcoran
...
Published: 6/16/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Autoimmune disease, BIO2026, Cell engineering, Cell therapy, Diagnostics, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Responsive Probiotic Therapy for Local Detection and Treatment of IBD Flares
SHORT DESCRIPTION
An engineered probiotic that senses intestinal inflammation via calprotectin and locally releases therapeutic antibodies in the gastrointestinal tract only during inflammatory flares.
INVENTORS
Arthur Prindle*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Jonathan...
Published: 6/16/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Autoimmune disease, BIO2026, Biologic, Cell therapy, Diagnostics, Gastrointestinal and Hepatic disease, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Synthetic biology, Therapeutics
Category(s): Life Sciences > Therapeutics
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