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A platform for mapping reactive cysteines within the immunopeptidome
NU 2024-044
INVENTORS
Xiaoyu Zhang*
Chenlu Zhang
Chen Zhou
SHORT DESCRIPTION
This invention provides novel chemical probes for mapping reactive cysteine residues within the major histocompatibility complex class I (MHC-I) immunopeptidome.
BACKGROUND
The immune system's recognition of infected or malignant cells hinges on the presentation...
Published: 12/11/2025
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Inventor(s):
Keywords(s): Biomarker, Immunology, Research reagent, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Assembly of Vaccines Using Cell-Free Integration of Viral Membrane Proteins into Liposomes
NU 2022-192
INVENTORS
Neha P. Kamat*
Vivian Hu
BACKGROUND
Virus infection posts a recurring global health challenge, and vaccines remain an effective protective against virus threats. However, many current vaccines face limitations including potential conversion of inactivated virus into pathogenic virus, immunogenicity of recombinant...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Immunology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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CAR T Cells Armored with IL15 for Treating Glioblastoma
NU 2022-074
INVENTORS
Irina V. Balyasnikova*
BACKGROUND
Glioblastoma is a devastating brain cancer for which no effective treatment exists, leading to short patient survival. Although investigations are underway to explore chimeric antigen receptor T (CAR-T) cells as glioblastoma therapy, the immunosuppressive tumor microenvironment (TME)...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Immunology
Category(s): Life Sciences > Therapeutics
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Methods and Compounds that block the release of enveloped viruses from cells
NU 2019-084
INVENTORS
Jonathan Leis*
Chi-Hao Luan
SHORT DESCRIPTION
Antiviral agents targeting a broad range of enveloped viruses for pan-viral therapeutics
BACKGROUND
To date, there are very few shared mechanisms identified between families of shared viruses. As such, there is minimal development of a broad-spectrum antiviral. Enveloped viruses...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Immunology, Immunotherapy, Infectious disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Clotrimazole as a treatment for immunodeficiency disorders
NU 2020-021
INVENTORS
Hossein Ardehali*
Adam De Jesus
SHORT DESCRIPTION
A drug that elicits inflammatory response as a therapeutic for immunodeficiency disorders
ABSTRACT
The primary hallmarks of Immunodeficiency disorders include suppression of the immune system and impaired response to infection, which can be fatal. There is currently a lack of...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Immunodeficiency, Immunology, Therapeutics
Category(s): Life Sciences > Therapeutics
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Immuno-Ablation Agent for Combination Therapy Against Solid Tumors
NU 2022-058
INVENTORS
Dong Hyun Kim*
Kijung Kwak
Bo Yu
SHORT DESCRIPTION
A method of co-delivering immune modulating agents during ethanol ablation of solid tumors
BACKGROUND
Ethanol ablation therapy is a simple and inexpensive method commonly employed to shrink solid tumors. Like other tumor ablation techniques, such as radiofrequency ablation,...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Drug delivery, Immunology, Immunotherapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Immunomodulatory Nanoparticles for the Therapeutic Intervention of Traumatic Brain Injury
NU 2019-030
INVENTORS
John Kessler
Sripadh Sharma
ABSTRACT
There is no decisive treatment for traumatic brain injury (TBI). After the primary trauma, secondary injury, largely mediated by blood-borne immune cells called monocytes, takes place causing damage to surrounding healthy cells. Furthermore, cellular and whole brain swelling (edema) resulting...
Published: 12/11/2025
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Inventor(s):
Keywords(s): Autoimmune disease, Brain injury, CNS - Central Nervous System, Immunology, Inflammation, Neurologic disease, Neurology, Therapeutics
Category(s): Life Sciences > Therapeutics
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S epidermidis Lipotechoic Acid (SELTA) for Immune Modulation
NU 2014-062INVENTORSStephen F MurphyPraveen Thumbikat*Anthony Schaeffer SHORT DESCRIPTIONA bacterial cell wall component to treat chronic pelvic pain syndrome.BACKGROUNDChronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) is a common debilitating disorder characterized by pelvic pain and lower urinary tract symptoms. However, due to limited understanding...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Arthritis, Biomedical, Immunology, Inflammation, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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A Live-Attenuated Vaccine for Urinary Tract and Other Bacterial Infections
NU 2008-004 Inventors Anthony J. Schaeffer*David J. KlumppBenjamin BillipsShort DescriptionA bacterial strain that promotes immune response for UTI treatmentAbstractUrinary tract infections, either chronic or acute, are a frequent health problem in a variety of populations. Northwestern investigators have demonstrated that deletion of a certain gene...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Immunology, Infectious disease, Therapeutics, Urology, Vaccine
Category(s): Life Sciences > Therapeutics
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Targeted Enhancement of CD154 Trimer Stability for Modulation of Immune Function
NU 2005-008 InventorsLaurence Howard John Irwin Stephen Miller* Brian Shoichet AbstractRegulating immune cell response is critical in combating disease. Northwestern researchers have developed a new therapy that can either inhibit immune cell function in autoimmune disease or enhance natural or vaccine-facilitated immune responses. A small molecule...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Autoimmune disease, Cancer/Oncology, Immunology, Infectious disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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