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Engineered Lipid Tags for Extracellular Vesicle Loading
NU 2022-178
INVENTORS
Neha Kamat*
Joshua Leonard*
Justin Alexander Peruzzi
Taylor Gunnels
SHORT DESCRIPTION
This technology enhances the loading of protein cargo into extracellular vesicles (EVs) by directing protein association with membrane lipid rafts, utilizing engineered lipid tags for targeted delivery.
BACKGROUND
Extracellular...
Published: 11/6/2025
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Updated: 2/28/2025
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Inventor(s):
Keywords(s): Biotechnology, Drug delivery, Nanoparticle, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Leveraging Lipid-Protein Interactions to Engineer Spatial Organization in Cell-free Systems
NU 2021-231
INVENTORS
Neha Kamat*
Justin Alexander Peruzzi
Jan Steinkuehler
SHORT DESCRIPTION
This innovative method enables the control of membrane protein location and distribution in synthetic lipid membranes using lipid-protein interactions, without chemical conjugation, facilitating the development of advanced cell-free systems.
BACKGROUND
Spatially...
Published: 4/9/2026
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Updated: 2/28/2025
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Inventor(s):
Keywords(s): Drug delivery, Nanomaterials, Nanoparticle, Nanotechnology, Research tool, Synthetic biology, Targeted therapy, Therapeutics
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Physical Sciences > Engineering & Technology
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Genetic circuits for engineering hypoxia-responsive cellular functions
NU 2021-259
INVENTORS
Joshua Leonard*
Patrick Donahue
SHORT DESCRIPTION
A customizable DNA based biosensor for detecting hypoxic environments
BACKGROUND
Cell-based therapies have been successful in treating many malignancies, leading to substantial increases in patient survival. However, translating these successes to the treatment of solid...
Published: 4/9/2026
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Updated: 1/28/2025
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Inventor(s):
Keywords(s): Biosensors, Cancer/Oncology, CVA - Cerebrovascular Accident, Regenerative medicine, Research tool, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Inflammation sensitive bacteria can detect flares of IBD
NU 2023-131
INVENTORS
Jonathan Xia
Arthur Prindle*
BACKGROUND
The prevalence of Inflammatory Bowel Disease (IBD), a spectrum of chronic autoimmune inflammatory disorders of the gastrointestinal tract, has steadily increased from 3.7 million in 1990 to 6.8 million in 2017. The spectrum of diseases are characterized by a relapsing and remitting...
Published: 3/26/2026
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Updated: 10/17/2024
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Inventor(s):
Keywords(s): Biologic, Diagnostics, Gastrointestinal and Hepatic disease, IBD - Inflammatory bowel disease, Infectious disease, Inflammation, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Modular Extracellular Sensors for Cell-based Biosensors
NU 2011-109BInventorsJoshua Leonard*Rachel Dudek Nichole Daringer Short DescriptionEngineered receptors designed to control gene expression BackgroundEngineering mammalian cell-based devices that monitor and therapeutically modulate human physiology is a promising and emerging frontier in clinical synthetic biology. However, realizing this vision required...
Published: 11/6/2025
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Updated: 10/14/2019
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Inventor(s):
Keywords(s): Animal Model, Diagnostics, Research tool, Sensors, Synthetic biology, Therapeutics
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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