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Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169
INVENTORS
Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN))
Brian Meckes
Wuliang Zhang
SHORT DESCRIPTION
For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 11/7/2025
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Inventor(s):
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
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Regioselective 1,2-Dearomatization of Functionalized Azines by Organolanthanide Catalysts
NU2014-129
INVENTORS
Tobin Marks*
Alexander Dudnik
Massimiliano Delferro
Victoria Weidner
SHORT DESCRIPTION
This invention describes a catalytic process for the regioselective 1,2-dearomatization of functionalized azines using an organolanthanide catalyst and pinacolborane (HBpin). It offers a streamlined approach to key intermediates for pharmaceuticals...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Catalyst, Chemicals, Manufacturing/Processing, Materials
Category(s): Physical Sciences > Materials and Industrial Processes
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Megalibrary Platform for Oxygen Evolution Reaction Catalysts
NU 2023-039
INVENTORS
Chad Mirkin*
Jin Huang
SHORT DESCRIPTION
A high-throughput nanoparticle megalibrary platform for discovering multielemental catalysts with enhanced activity and stability for oxygen evolution reactions in electrochemical energy systems.
BACKGROUND
The oxygen evolution reaction (OER) is a critical reaction in electrochemical...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Chemicals, Cleantech, Materials, Nanomaterials, Nanoparticle, Spectroscopy
Category(s): Physical Sciences > Materials and Industrial Processes
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A Low-Temperature, Energy Neutral Process For Preparing Formaldehyde From Neat Or Aqueous Methanol
NU 2015-173
Inventors
Tobin Marks*
Peter Stair
Tracy Lohr
Background
Rapid low-temperature/low-pressure methanol reforming, mediated by a supported molybdenum catalyst, produces formaldehyde and a stoichiometric quantity of H2 without co-production of greenhouse gases (see Figure 1). Formaldehyde is a valuable commodity chemical, the current...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Catalyst, Chemicals, Cleantech, Energy and Infrastructure, Hydrogen, Manufacturing/Processing, Materials
Category(s): Physical Sciences > Energy & Sustainability
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Flexible Thermoelectric Fabrics for Thermal Management
NU 2018-037
INVENTORS
Matthew Grayson*
Adam Edward Jakus
Jun Peng
Nicholas Geisendorfer
Ramille Shah
SHORT DESCRIPTION
This technology introduces ground-breaking flexible, woven thermoelectric materials capable of converting waste heat into electrical power, ideal for wearable tech and low-power devices.
BACKGROUND
Waste heat is an underutilized...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Chemicals, Cleantech, Computer hardware, Consumer product, Electronics & Circuits, Engineering, Inks, Manufacturing/Processing, Materials, Novel Energy, Renewable, Semiconductors & Integrated Circuits, Thermoelectric
Category(s): Physical Sciences > Materials and Industrial Processes
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Styrene Functionalized Cyclodextrin Monomers and Polymer for Water Remediation
Styrene Functionalized Cyclodextrin Monomers and Polymer for Water Remediation
NU 2021-229
INVENTORS
Damian Helbling*
William Dichtel*
Brittany Bac-An Trang
Max Klemes
Mohamed Ibrahim
Ri Wang
Zhi-wei Lin
SHORT DESCRIPTION
This invention discloses styrene functionalized beta-cyclodextrin monomers and their mesoporous polymeric networks,...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Chemicals, Cleantech, Ecosystems and Resilience, Environment, Health & Safety, Materials, Polymer, Remediation
Category(s): Physical Sciences > Materials and Industrial Processes
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A Precise Polyrotaxane Synthesizer
NU 2020-106
INVENTORS
James F Stoddart*
Yunyan Qiu
ABSTRACT
Mechanically interlocked molecules constitute one of the first ports of call for designing and synthesizing artificial molecular machines. Although polyrotaxanes have already found niche applications in exotic materials with unique mechanical properties, efficient synthetic protocols to produce...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Chemicals, Manufacturing/Processing, Polymer
Category(s): Physical Sciences > Materials and Industrial Processes
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Cyclophane-Sustained High Performance Porphyrins
NU 2020-089
INVENTORS
James F Stoddart*
Wenqi Liu
SHORT DESCRIPTION
High performance dyes for diagnosis and therapy
ABSTRACT
Porphyrins and metalloporphyrins are functional dyes with distinctive photo-physical properties, showing great potentials for biomedical applications. Meanwhile, practical applications of these dyes suffer from several well-known...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Chemicals, Imaging
Category(s): Physical Sciences > Materials and Industrial Processes
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Mechanical Bond-Protected Stable Bisradicals
NU 2020-049
INVENTORS
J Fraser Stoddart*
Kang Cai
ABSTRACT
Traditional organic radicals are not stable in air, and NIR dyes with absorption wavelength longer than 1300 nm is difficult to obtain. Northwestern researchers have developed two new highly positively charged catenanes that display highly stable mono-and diradical states under ambient conditions...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Chemicals, Manufacturing/Processing
Category(s): Physical Sciences > Materials and Industrial Processes
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High-Efficiency Gold Recovery
NU 2020-041
INVENTORS
J Fraser Stoddart*
Huang Wu
ABSTRACT
For well over a century now, 83% of gold production has depended on a cyanide-leaching process, while that remaining in the debris is often treated with mercury. Both cyanide and mercury, however, are highly toxic, causing human health hazards and serious environmental pollution...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Chemicals, Environment
Category(s): Physical Sciences > Materials and Industrial Processes
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