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Precision Gene Therapy for Diseases Driven by Endothelial Dysfunction
SHORT DESCRIPTION
Dual promoter system constructs for tissue-specific and cell-type-specific gene expression, enabling precision gene therapy targeting endothelial dysfunction in specific organs.
INVENTORS
Youyang Zhao*
Ann & Robert H Lurie Children's Hospital of Chicago
* Principal Investigator
NU...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, CMD - Cardiometabolic disease, CPD - Cardiopulmonary disease, Gene therapy, Pulmonary disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease
Category(s): Life Sciences > Therapeutics
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Drug Repurposing for Age-Impaired Vascular Repair in COVID-19, Sepsis, and ARDS
SHORT DESCRIPTION
Methods and compositions for treating COVID-19, sepsis, acute respiratory distress syndrome (ARDS), and cardiovascular diseases in elderly patients by either inhibiting vascular endothelial injury/inflammation or promoting FOXM1-dependent endothelial regeneration and vascular repair.
INVENTORS
Youyang Zhao
Northwestern...
Published: 4/27/2026
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Updated: 4/22/2026
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Inventor(s):
Keywords(s): ARDS - Acute Respiratory Distress Syndrome, COVID-19, Immunology, Infectious disease, Inflammation, Pulmonary disease, Therapeutics, Vascular disease, Vascular repair
Category(s): Life Sciences > Therapeutics
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Methods for Treatment of Sepsis and Acute Respiratory Distress Syndrome
LU2025-192
INVENTORS
Youyang Zhao
Colin Evans
SHORT DESCRIPTION
This invention identifies endothelial ALOX15 and its lipid product, 1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol (POLAR), as key targets for treating sepsis and acute respiratory distress syndrome (ARDS).
BACKGROUND
Sepsis-induced acute lung injury (ALI) and acute...
Published: 2/16/2026
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Updated: 10/17/2025
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Inventor(s):
Keywords(s): ARDS - Acute Respiratory Distress Syndrome, Lung disease, Sepsis, Therapeutics, Vascular disease, Vascular repair
Category(s): Life Sciences > Therapeutics
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