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Precision Gene Therapy for Diseases Driven by Endothelial Dysfunction
SHORT DESCRIPTION
Dual promoter system constructs for tissue-specific and cell-type-specific gene expression, enabling precision gene therapy targeting endothelial dysfunction in specific organs.
INVENTORS
Youyang Zhao*
Ann & Robert H Lurie Children's Hospital of Chicago
* Principal Investigator
NU...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, CMD - Cardiometabolic disease, CPD - Cardiopulmonary disease, Gene therapy, Pulmonary disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease
Category(s): Life Sciences > Therapeutics
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Netrin-1 mimetic peptide amphiphiles
Netrin-1 Mimetic Peptide Amphiphile Assemblies
NU 2024-174
INVENTORS
Samuel Stupp*
Cara Smith
Zaida Alvarez Pinto
SHORT DESCRIPTION
Nanofiber-shaped supramolecular assemblies that mimic netrin-1 bioactivity to stimulate neurite growth and synaptic maturation for enhanced CNS regeneration.
BACKGROUND
Neurotrophic factors are essential for...
Published: 2/20/2026
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Updated: 2/20/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, CNS - Central Nervous System, CVA - Cerebrovascular Accident, Nanomaterials, Nanotechnology, Neurodegenerative disease, Regenerative medicine, SCI - Spinal cord injury, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Sliding Bioactive Peptides for Therapeutic Delivery
NU 2023-142
INVENTORS
Samuel I. Stupp*
Federico Lancia
Madison E. Strong
Matias A. Alvarez-Saavedra
SHORT DESCRIPTION
This technology involves the design and engineering of peptide amphiphile nanofibers that deliver bioactive peptides both extra- and intra-cellularly. The bioactive peptides can slide along these structures...
Published: 1/9/2026
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Updated: 5/2/2025
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Inventor(s):
Keywords(s): Biomaterials, CNS - Central Nervous System, Drug delivery, Neurologic disease, Neurology, Regenerative medicine, SCI - Spinal cord injury, Therapeutics
Category(s): Life Sciences > Therapeutics
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Genetic circuits for engineering hypoxia-responsive cellular functions
NU 2021-259
INVENTORS
Joshua Leonard*
Patrick Donahue
SHORT DESCRIPTION
A customizable DNA based biosensor for detecting hypoxic environments
BACKGROUND
Cell-based therapies have been successful in treating many malignancies, leading to substantial increases in patient survival. However, translating these successes to the treatment of solid...
Published: 4/9/2026
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Updated: 1/28/2025
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Inventor(s):
Keywords(s): Biosensors, Cancer/Oncology, CVA - Cerebrovascular Accident, Regenerative medicine, Research tool, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Reelin for the Clinical Treatment of Cardiac Pathologies
NU 2020-159
INVENTORS
Guillermo Oliver*
Xialoei Liu
SHORT DESCRIPTION
A novel approach to treating cardiovasculature disease
BACKGROUND
Although little is known about the role of cardiac lymphatics in the healthy or failing heart, a growing body of evidence indicates that improved cardiac lymphatic vessel growth and function could be a novel therapeutic...
Published: 12/11/2025
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Updated: 8/10/2021
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Inventor(s):
Keywords(s): Biologic, Cardiology and Cardiovascular disease, Regenerative medicine, Therapeutics
Category(s): Life Sciences > Therapeutics
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