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Small Molecule for Bladder Repair
NU 2021-153
INVENTORS
Arun Sharma*
Matthew Bury
Natalie Fuller
SHORT DESCRIPTION
A small molecule to improve the regenerative outcomes of injured or diseased urinary bladder tissue
ABSTRACT
Northwestern researchers have identified a small molecule that facilitates the repair and restoration of damaged urinary bladder tissue following loss of...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Drug discovery, Small molecule, Therapeutics, Urology
Category(s): Life Sciences > Therapeutics
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Compounds and methods of identifying novel E3 ligases for targeted protein degradation
NU 2023-096
INVENTORS
Ananya Angela Basu
Xiaoyu Zhang*
SHORT DESCRIPTION
A CRISPR-activation screen for discovering E3 ligases amenable to targeted protein degradation, and a novel PROTAC for FBXO22
BACKGROUND
Traditional small molecule drugs function by directly interfering with the activities of proteins. However, many proteins lack suitable...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Drug discovery, Proteomics, Small molecule
Category(s): Life Sciences > Therapeutics
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Exercise Induced Myokines to Target Receptor Kinases and Chromatin Architecture
NU 2019-094
INVENTORS
Vadim Backman*
Hemant K. Roy
SHORT DESCRIPTION
Novel oncology drug discovery platform using contraction-induced myokine secretion
BACKGROUND
Colorectal cancer is the third most commonly diagnosed cancer and second most common cause of cancer deaths in the United States. Despite its frequency, there are limited treatment...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Drug discovery, Personalized medicine
Category(s): Life Sciences > Therapeutics
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An Automated Fluidic Plate System for Culturing Multiple Cell Types
NU 2016-207BInventorsTeresa Woodruff*Hunter RogersShort DescriptionLaboratory automation compatible fluidic culture platform for drug discovery BackgroundThe current financial and time commitment for a pharmaceutical company to bring a drug to market is approximately $2 billion and 10 years, respectively. A significant portion of that cost is due to...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Biomedical, Drug discovery, Obstetric/Gynecological, Research tool, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Treatment of Multiple Myeloma using FDA-Approved HIV Drug
NU 2011-013BInventorsSamuel McBrayerSteven Rosen*Malathy ShanmugamShort DescriptionNovel strategy to compromise the metabolism of myeloma cells and induce tumor regression in multiple myeloma (MM) patientsAbstractNorthwestern researchers have developed a novel strategy to treat multiple myeloma. They capitalize on a fatal plasma cell malignancy characteristic,...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Drug discovery, Therapeutics
Category(s): Life Sciences > Therapeutics
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Identification of First-In-Class Therapeutics Called Viral Budding Inhibitors
NU 2012-068B
Inventors
Jonathan Leis*
Carol Carter
Short Description
Small molecules that block viral budding from infected cells
Background
Current HIV treatment involves a cocktail of drugs that target viral entry or virus-specific enzymes. Despite the widespread use of these antivirals, over 1 M were diagnosed with AIDS in the USA...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Drug discovery, Research tool, Small molecule
Category(s): Life Sciences > Therapeutics
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A Mouse Model to Visualize Motor Neurons
NU 2012-053 Inventor Pembe Hande Ozlinder AbstractNorthwestern researchers have developed a novel mice model that enables the visualization of both corticospinal and spinal motor neurons. In addition to enabling the in vivo visualization of these neurons at different stages of motor neuron disorders, this method also provides the capability to isolate...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Animal Model, Cell Line, Drug discovery, Neurology, Research reagent
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Mouse Model for Endocrine Pancreatic Development, Insulin Secretion and Diabetes
NU 2010-071InventorsJoseph Bass*Biliana MarchevaShort DescriptionA mouse model based on removing the clock function within islet cellsAbstractNorthwestern researchers created a mouse model based on removing the clock function within islet cells. These mice exhibit striking defects in insulin secretion which ultimately leads to greatly accelerated early...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Animal Model, Diabetes, Drug discovery, Research tool, Stem cell
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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A Novel Therapeutic Treatment for Toxoplasmosis and Malaria
NU 2016-166 InventorsRichard Silverman*Hoang LeRima McLeod Short DescriptionSelective inactivation of ornithine aminotransferase for treating toxoplasmosis and malaria BackgroundToxoplasmosis, the disease caused by the parasite Toxoplasma gondii (T. gondii), is the leading cause of death attributed to food-borne illness in the United States. Another...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Chemicals, Drug discovery, Therapeutics
Category(s): Life Sciences > Therapeutics
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Irreversible tethering method for screening for covalent inhibitors of enzymes
NU 2014-002 InventorsAlexander V. Statsyk* Stefan G. Kathman Short DescriptionAn unbiased library of compounds was generated using a one-step method in order to screen for covalent inhibitors of enzymes AbstractEnzyme inhibitors that covalently modify their target are gaining in popularity due to their high potency even at low doses and lack of susceptibility...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Assay, Biomedical, Drug discovery, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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