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Precision Gene Therapy for Diseases Driven by Endothelial Dysfunction
SHORT DESCRIPTION
Dual promoter system constructs for tissue-specific and cell-type-specific gene expression, enabling precision gene therapy targeting endothelial dysfunction in specific organs.
INVENTORS
Youyang Zhao*
Ann & Robert H Lurie Children's Hospital of Chicago
* Principal Investigator
NU...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, CMD - Cardiometabolic disease, CPD - Cardiopulmonary disease, Gene therapy, Pulmonary disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease
Category(s): Life Sciences > Therapeutics
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A new therapeutic approach for treating and reversing heart failure with preserved ejection fraction
NU 2022-216
INVENTORS
Hossein Ardehali*
Yuki Tatekoshi
SHORT DESCRIPTION
A small-molecule inhibitor for treating, preventing, and reversing heart failure with preserved ejection fraction (HFpEF).
ABSTRACT
HFpEF is a common cause of mortality worldwide, but the underlying pathophysiology is not well understood and treatment options are limited....
Published: 3/31/2026
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Updated: 3/21/2024
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, CPD - Cardiopulmonary disease
Category(s): Life Sciences > Therapeutics
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A Terlipressin-Albumin Conjugate for Increased Stability
NU2018-179
INVENTORS
Nathan Gianneschi*
Or Berger
Wonmin Choi
SHORT DESCRIPTION
A new compound consisting of terlipressin coupled to an 18-carbon (C-18) fatty acid that allows the drug to bind to albumin, providing increased stability.
BACKGROUND
Terlipressin, an analogue of vasopressin, is used in many countries around the world to treat...
Published: 4/15/2026
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Updated: 6/3/2022
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, CPD - Cardiopulmonary disease, Drug delivery, Therapeutics
Category(s): Life Sciences > Therapeutics
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