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Precision Gene Therapy for Diseases Driven by Endothelial Dysfunction
SHORT DESCRIPTION
Dual promoter system constructs for tissue-specific and cell-type-specific gene expression, enabling precision gene therapy targeting endothelial dysfunction in specific organs.
INVENTORS
Youyang Zhao*
Ann & Robert H Lurie Children's Hospital of Chicago
* Principal Investigator
NU...
Published: 5/8/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, CMD - Cardiometabolic disease, CPD - Cardiopulmonary disease, Gene therapy, Pulmonary disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease
Category(s): Life Sciences > Therapeutics
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A new therapeutic approach for treating and reversing heart failure with preserved ejection fraction
NU 2022-216
INVENTORS
Hossein Ardehali*
Yuki Tatekoshi
SHORT DESCRIPTION
A small-molecule inhibitor for treating, preventing, and reversing heart failure with preserved ejection fraction (HFpEF).
ABSTRACT
HFpEF is a common cause of mortality worldwide, but the underlying pathophysiology is not well understood and treatment options are limited....
Published: 3/31/2026
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Updated: 3/21/2024
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, CPD - Cardiopulmonary disease
Category(s): Life Sciences > Therapeutics
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Novel Therapeutic Target for Treating Lung Disease
NU2022-231
INVENTORS
Ankit Bharat*
Yuanqing Yan
SHORT DESCRIPTION
A novel protein target for treating chronic and acute lung diseases
ABSTRACT
Lung diseases caused by pulmonary fibrosis can be fatal, and the currently approved drugs for treating pulmonary fibrosis, including Nintedanib and Pirfenidone, only slow down the disease progression....
Published: 6/3/2026
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Updated: 2/22/2024
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Inventor(s):
Keywords(s): CPD - Cardiopulmonary disease, Inflammation, Lung disease
Category(s): Life Sciences > Therapeutics
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A Terlipressin-Albumin Conjugate for Increased Stability
NU2018-179
INVENTORS
Nathan Gianneschi*
Or Berger
Wonmin Choi
SHORT DESCRIPTION
A new compound consisting of terlipressin coupled to an 18-carbon (C-18) fatty acid that allows the drug to bind to albumin, providing increased stability.
BACKGROUND
Terlipressin, an analogue of vasopressin, is used in many countries around the world to treat...
Published: 4/15/2026
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Updated: 6/3/2022
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, CPD - Cardiopulmonary disease, Drug delivery, Therapeutics
Category(s): Life Sciences > Therapeutics
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