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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION
Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma.
INVENTORS
Amy Heimberger*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
* Principal Investigator
NU 2025-212
IP STATUS
US...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunology, Immunotherapy, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets
SHORT DESCRIPTION
A targeted-protein degradation platform for intracellular targets, addressing resistant oncogenic and neurodegenerative targets.
INVENTORS
Shana Kelley*
Weinberg College of Arts & Sciences, Department of Chemistry
Yi Li
* Principal Investigator
NU 2025-050
IP STATUS
PCT...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Biologic, Biomolecular condensates, Cancer/Oncology, Drug delivery, Nanoparticle, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Platform technology, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Use of Neuronal NOS Inhibitors for Alzheimer's Therapeutic Intervention
PROPOSED TITLE (cut & paste into Alternate Title): Use of Neuronal NOS Inhibitors for Alzheimer's Therapeutic Intervention
NU 2023-007
SHORT DESCRIPTION
A small molecule based approach that mitigates Alzheimer's neurodegeneration by inhibiting neuronal nitric oxide synthase to prevent tau phosphorylation and reduce Aβ oligomer formation.
INVENTORS
Richard...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Covalent inhibitor, Kinase Inhibitor, Neurodegenerative disease, Neurology, nNOS, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Noninvasive brain-specific inhibition of bone morphogenetic protein signaling for the prevention of tauopathy
NU2025-330
INVENTORS
John Kessler*
Justin Geier
Chian-Yu Peng
SHORT DESCRIPTION
This invention uses a noninvasive gene therapy approach to prevent and treat tauopathies, such as Alzheimer's disease and frontotemporal dementia, by inhibiting bone morphogenetic protein (BMP) specifically within the central nervous system.
BACKGROUND
Tauopathies...
Published: 3/27/2026
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Updated: 3/26/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Gene therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Aminopyrimidine-based Kinase Inhibitors for Treatment of Cancer
NU 2015-098
Inventors
Leonidas C. Platanias*
Gary E. Schiltz
Rama K. Mishra
Short Description
A small molecule to treat glioblastoma multiforme by blocking the Mnk pathway.
Background
Glioblastoma multiforme (GBM) is an aggressive brain cancer associated with a low survival rate, high recurrence, and limited therapeutic options. Most diagnosed...
Published: 3/5/2026
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Updated: 3/5/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Netrin-1 mimetic peptide amphiphiles
Netrin-1 Mimetic Peptide Amphiphile Assemblies
NU 2024-174
INVENTORS
Samuel Stupp*
Cara Smith
Zaida Alvarez Pinto
SHORT DESCRIPTION
Nanofiber-shaped supramolecular assemblies that mimic netrin-1 bioactivity to stimulate neurite growth and synaptic maturation for enhanced CNS regeneration.
BACKGROUND
Neurotrophic factors are essential for...
Published: 2/20/2026
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Updated: 2/20/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, CNS - Central Nervous System, CVA - Cerebrovascular Accident, Nanomaterials, Nanotechnology, Neurodegenerative disease, Regenerative medicine, SCI - Spinal cord injury, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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TauSeeK: Disease Specific Tau Protein Fibrils & Seeding Proteins
NU 2024-154
INVENTORS
Songi Han*
Austin Dubose
Michael Vigers
Andrew Longhini
Vishnu Vijayan
Kenneth Kosik
Samuel Lobo
Peter C. Ryffel
Lokeswara Rao Potnuru
Karen Tsay
Chung-Ta Han
SHORT DESCRIPTION
Compositions, kits, and methods for generating synthetic miniature tau peptides and fibrils, and synthetic full-length pathogenic tau...
Published: 3/23/2026
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Updated: 10/30/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Drug discovery, Drug screening, HD - Huntington's Disease, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Compositions and Methods for Treating Alzheimer’s Disease
2018-043
INVENTORS
Sergio T. Ferreira
Diana Jerusalinsky
William L. Klein*
SHORT DESCRIPTION
A novel gene transfer approach for brain delivery of an antibody for Alzheimer’s disease treatment
BACKGROUND
Alzheimer’s disease, a progressive form of neurodegeneration that causes impairs memory and cognition, currently impacts over...
Published: 11/6/2025
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Updated: 6/1/2023
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Combination Treatment to Reduce Pathological Proteins in Neurodegenerative and Lysosomal Storage Diseases
NU 2021-206
INVENTORS
Joseph Mazzulli*
Iva Stojkovska
SHORT DESCRIPTION
A small molecule combination treatment to improve lysosomal function in neurodegenerative and lysosomal storage diseases
BACKGROUND
Many neurodegenerative disorders are characterized by a collapse in proteostasis, as shown by the accumulation of insoluble protein aggregates...
Published: 12/16/2025
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Updated: 5/23/2022
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, ALS - Amyotrophic Lateral Sclerosis, HD - Huntington's Disease, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Deep Learning Structural Analysis Of Cerebral Cortex Predicts Features From MRI Data
NU 2020-152
INVENTORS
Pierre Alain Besson
S. Kathleen Bandt*
SHORT DESCRIPTION
Graph convolutional neural networks (gCNNs) successfully predict patient age and sex from T1-weighted brain surface MRI data.
BACKGROUND
As clinical image-based data sets grow in resolution and size, the promise of machine learning greatly expedites image classification...
Published: 11/6/2025
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Updated: 8/10/2021
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Artificial Intelligence & Machine Learning, Computer software, CVA - Cerebrovascular Accident, Data processing/analysis, Image/Signal processing, Neurologic disease, PD - Parkinson's Disease
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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