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Compositions and Methods for Treating Alzheimer’s Disease
2018-043
INVENTORS
Sergio T. Ferreira
Diana Jerusalinsky
William L. Klein*
SHORT DESCRIPTION
A novel gene transfer approach for brain delivery of an antibody for Alzheimer’s disease treatment
BACKGROUND
Alzheimer’s disease, a progressive form of neurodegeneration that causes impairs memory and cognition, currently impacts over...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Combination Treatment to Reduce Pathological Proteins in Neurodegenerative and Lysosomal Storage Diseases
NU 2021-206
INVENTORS
Joseph Mazzulli*
Iva Stojkovska
SHORT DESCRIPTION
A small molecule combination treatment to improve lysosomal function in neurodegenerative and lysosomal storage diseases
BACKGROUND
Many neurodegenerative disorders are characterized by a collapse in proteostasis, as shown by the accumulation of insoluble protein aggregates...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Biomedical, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Small molecule
Category(s): Life Sciences > Therapeutics
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Deep Learning Structural Analysis Of Cerebral Cortex Predicts Features From MRI Data
NU 2020-152
INVENTORS
Pierre Alain Besson
S. Kathleen Bandt*
SHORT DESCRIPTION
Graph convolutional neural networks (gCNNs) successfully predict patient age and sex from T1-weighted brain surface MRI data.
BACKGROUND
As clinical image-based data sets grow in resolution and size, the promise of machine learning greatly expedites image classification...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Artificial Intelligence & Machine Learning, Computer software, CVA - Cerebrovascular Accident, Data processing/analysis, Image/Signal processing, Neurologic disease, PD - Parkinson's Disease
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Nanostructures for Diagnosis and Therapy of Alzheimer's Disease
NU 2009-169 Inventors Vinayak Dravid* Saurabh Sharma Kristen Viola William Klein* Short Description Novel magnetic nanostructures that recognize toxic beta-amyloid protein oligomers responsible for Alzheimer's disease progression Abstract Northwestern University researchers have developed a new magnetic nanostructure that can be used to detect and...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Biomarker, Devices, Diagnostics, Health IT, Medical device, Nanoparticle, Neurodegenerative disease, Neurologic disease, Research tool, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Tau-7: Monoclonal Antibody Specific for the C-Terminus of Tau
NU 2008-109InventorLester BinderShort DescriptionTau-7 is a mouse monoclonal antibody (mAb) that binds to the carboxy terminal region of human tau. AbstractResearcher Lester Binder has created a series of useful antibodies that are specific for the human tau protein. This particular antibody, Tau-7 mAb, is of the IgG1 isotype and would be useful to...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Antibody, Diagnostics, Imaging, Neurodegenerative disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Selective Human Sirtuin-2 Inhibitors, the Therapeutic Candidate for Huntington's Disease
NU 2012-145InventorsRichard Silverman*Hua WangMohammad KhanfarAleksey KazantsevShort DescriptionSelective human sirtuin-2 inhibitors for use in treating Huntington's diseaseAbstractNorthwestern researchers have discovered a new series of selective human sirtuin-2 inhibitors which show excellent neuronal protection in the Huntington's disease model....
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Stable, Potent Compounds to Selectively Inhibit Neuronal Nitric Oxide Production
NU 2011-053 Inventors Haitao Mark Ji Richard B. Silverman* He Huang Abstract Nitric oxide (NO) is a critical neurotransmitter. Overproduction of NO has been implicated in a variety of neurological diseases, including Parkinson's, Alzheimer's, and Huntington's, as well as neuronal damage occurring in stroke patients. Inhibitors of the enzyme...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, CVA - Cerebrovascular Accident, Neurologic disease, Neurology, PD - Parkinson's Disease, Research reagent, Research tool, Therapeutics
Category(s): Life Sciences > Therapeutics
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Tau-C3: Monoclonal Antibody Specific to Tau Truncated at Aspartic Acid
NU 2003-065
Inventor
Lester Binder*
Short Description
Tau-C3, is a mouse monoclonal antibody (mAb) that binds to human tau truncated at aspartic acid 421
Abstract
Researcher Lester Binder has created a series of useful antibodies that are specific for the human tau protein, pertinent to Alzheimer research. This particular antibody, Tau-C3,...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Antibody, Diagnostics, Neurodegenerative disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Aminopyrimidine-based Kinase Inhibitors for Treatment of Cancer
NU 2015-098InventorsLeonidas C. Platanias*Gary E. SchiltzRama K. MishraShort DescriptionA small molecule to treat glioblastoma multiforme by blocking the Mnk pathway. BackgroundGlioblastoma multiforme (GBM) is an aggressive brain cancer associated with a low survival rate, high recurrence, and limited therapeutic options. Most diagnosed patients die...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Transgenic Mouse Model of Amyloid Pathogenesis
NU 2009-195 Inventors John Csernansky* Hongxin Dong Louis Muglia Short Description Mouse model for directly testing the involvement of stress in Alzheimer's disease progress Abstract Northwestern researchers have engineered a triple transgenic mouse that can be used to investigate the contribution of stress to development of Alzheimer's Disease...
Published: 11/6/2025
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Animal Model, Neurodegenerative disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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