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Inhibitors of MNK Kinase for Targeted Cancer and CNS Therapeutics
NU 2015-098B (NU 2015-098, NU 2018-036, NU 2025-036)
INVENTORS
Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)*
SHORT DESCRIPTION
MNK kinase inhibitors that reduce cancer cell viability and proliferation and penetrates the brain for potential treatment of glioblastoma and CNS disorders.
BACKGROUND
Leukemia and brain...
Published: 7/2/2026
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Updated: 4/29/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, AML - Acute myeloid leukemia, ASD - Autism Spectrum Disorder, BIO2026, Bladder cancer, Brain cancer, Breast cancer, Cancer/Oncology, CNS - Central Nervous System, Colon cancer, Lung cancer, Neurodegenerative disease, Pancreatic cancer, Prostate cancer, Small molecule, Targeted therapy, Therapeutics, TPD - Targeted protein degradation
Category(s): Life Sciences > Therapeutics
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Targeting IL-6 pathway to treat high risk myelodysplastic syndromes
NU 2022-093
INVENTORS
Peng Ji*
Kehan Ren
Yang Mei
SHORT DESCRIPTION
A method of inhibiting progression of high-risk myelodysplastic syndrome (MDS) or low blast count acute myeloid leukemia (AML) using an inhibitor of IL6 signaling.
BACKGROUND
Approximately 20,000 people in the US are diagnosed with myelodysplastic syndrome (MDS) each year....
Published: 7/2/2026
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Updated: 2/17/2026
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Inventor(s):
Keywords(s): AML - Acute myeloid leukemia, Cancer/Oncology, Repurposed Drugs, Therapeutics
Category(s): Life Sciences > Therapeutics
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Substituted aromatic heterocycles and uses thereof for inhibiting mitogen-activated protein kinase interacting kinase 1 (Mnk1) and 2 (Mnk2)
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NU 2018-036
INVENTORS
Gary E. Schlitz
Javier Izquierdo-Ferrer
Purav Vagadia
Matther R. Clutter
Rama K. Mishra
Leonidas C. Platanias*
SHORT DESCRIPTION
Novel Mnk1 and Mnk2 inhibitors for treating acute myeloid leukemia
BACKGROUND
Acute myeloid leukemia (AML) is a type of cancer that originates...
Published: 6/16/2026
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Updated: 6/1/2023
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Inventor(s):
Keywords(s): AML - Acute myeloid leukemia, BIO2026, Cancer/Oncology, Leukemia, Therapeutics
Category(s): Life Sciences > Therapeutics
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