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Incomplete Autophagy Induction for the Treatment of Cancer
SHORT DESCRIPTION
This incomplete autophagy inducer triggers caspase-mediated apoptosis in cancer cells by inducing incomplete autophagy, leading to tumor reduction and improved survival.
INVENTORS
INVENTORS
Maciej Lesniak*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
Jawad...
Published: 5/13/2026
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Updated: 5/7/2026
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Inventor(s):
Keywords(s): Autophagy, Brain cancer, Breast cancer, Cancer/Oncology, Lung cancer, Melanoma, Repurposed Drugs, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Covalent ATG4B Inhibitors for Treatment of Cancer
NU 2025-186
INVENTORS
Karl Scheidt*
Weinberg College of Arts and Sciences, Department of Chemistry
Claire Trudeau
Shiyuan Cheng
SHORT DESCRIPTION
The invention introduces a novel class of peptidyl covalent reversible ketoamide inhibitors designed to target the cysteine protease ATG4B.
BACKGROUND
Glioblastoma (GBM) is an aggressive...
Published: 5/13/2026
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Updated: 10/28/2025
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Inventor(s):
Keywords(s): Autophagy, Brain cancer, Cancer/Oncology, GBM - Glioblastoma, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Methods for Enhancing GBM Treatment Through Inhibition of Autophagy Mediator ATG4B
NU 2019-106
INVENTORS
Shi-Yuan Cheng*
Feinberg School of Medicine, Department of Neurology
Bo Hu
Tianzhi Huang
SHORT DESCRIPTION
A novel autophagy inhibitor to enhance the efficiency of standard cancer treatments
BACKGROUND
Glioblastoma (GBM), an incurable, lethal disease, exhibits a poor 5-year survival rate. The usual treatment...
Published: 5/13/2026
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Updated: 6/1/2023
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Inventor(s):
Keywords(s): Autophagy, Brain cancer, Cancer/Oncology, GBM - Glioblastoma, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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