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Neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and neurodegenerative disorders
NU 2025-113 (NU 2016-137, NU 2018-176, NU 2019-179, NU 2023-007, NU 2024-250, NU 2025-038)
INVENTORS
Richard Silverman (Weinberg College of Arts and Sciences, Department of Chemistry)
SHORT DESCRIPTION
Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and other cancers with high expression...
Published: 4/1/2026
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Updated: 4/1/2026
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Inventor(s):
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, AUTM26C1, BIAUTM1, Cancer/Oncology, Cardiology and Cardiovascular disease, Immunodeficiency, Immunology, Immunotherapy, Melanoma, Neurodegenerative disease, Neuroinflammation, nNOS, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Targeting EGFR Co-Amplified Long-Noncoding RNA for Glioblastoma Treatment
NU 2025-335
INVENTORS
Shi-Yuan Cheng*
Xiaozhou Yu
Bo Hu
Runxin Wu
Xiao Song
SHORT DESCRIPTION
This invention provides compositions and methods for inhibiting ELDR and HELDR, two long non-coding RNAs (lncRNAs) that are frequently co-amplified in glioblastoma (GBM) with the epidermal growth factor receptor (EGFR) gene, and which drive tumorigenesis...
Published: 3/30/2026
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Updated: 3/30/2026
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Inventor(s):
Keywords(s): Brain cancer, Cancer Treatment, Cancer/Oncology, Therapeutics
Category(s): Life Sciences > Therapeutics
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Targeted pH Sensitive Liposomes
NU 2020-170
INVENTORS
Leo Gordon*
Dong-Hyun Kim*
Shuo Yang
Wooram Park
Taehoon Sim
SHORT DESCRIPTION
Liposomal nanoparticles composed of pH-sensitive lipids and apolipoprotein that encapsulate andrographolide for lymphoma treatment.
BACKGROUND
Lymphoma, particularly diffuse large B-cell lymphoma (DLBCL), is the most common aggressive type...
Published: 3/11/2026
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Updated: 3/11/2026
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Inventor(s):
Keywords(s): Blood & Lymphatic disease, Cancer/Oncology, Nanoparticle, Therapeutics
Category(s): Life Sciences > Therapeutics
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Aminopyrimidine-based Kinase Inhibitors for Treatment of Cancer
NU 2015-098
Inventors
Leonidas C. Platanias*
Gary E. Schiltz
Rama K. Mishra
Short Description
A small molecule to treat glioblastoma multiforme by blocking the Mnk pathway.
Background
Glioblastoma multiforme (GBM) is an aggressive brain cancer associated with a low survival rate, high recurrence, and limited therapeutic options. Most diagnosed...
Published: 3/5/2026
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Updated: 3/5/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Covalent PRC2 Inhibitors for Advanced Cancer Therapeutics
SHORT DESCRIPTION
Covalent inhibitors and proteolysis-targeting chimera (PROTAC) degraders targeting components of the PRC2 complex (EZH and EED) to block both enzymatic and non-enzymatic functions, offering robust anti-tumor efficacy.
INVENTORS
Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)*
Jindan...
Published: 4/7/2026
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Updated: 3/5/2026
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Bladder cancer, Breast cancer, Cancer/Oncology, Covalent inhibitor, Lymphoma, Melanoma, PreSeed/Seed, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Methods of Using Modified Cytotoxins to Treat Cancer
NU 2019-135
INVENTORS
Nathan Gianneschi*
SHORT DESCRIPTION
Methods for treating cancers that overexpress fatty acid uptake proteins using small-molecule cytotoxic drugs conjugated to long-chain fatty acid moieties. See also NU2022-111 and NU2022-109.
BACKGROUND
While prior work (under NU2022-111) demonstrated that lipid-mimicking cytotoxin...
Published: 2/26/2026
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Updated: 2/25/2026
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Inventor(s):
Keywords(s): Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Deep learning for automated, motion-resolved tumor segmentation in radiotherapy
NU2025-264
INVENTORS
Mohamed Abazeed*
Sagnik Sarkar
Peng Thian Troy Teo
SHORT DESCRIPTION
This invention describes a method for automatically outlining lung tumors for radiotherapy planning. It uses deep learning to precisely identify tumors across breathing cycles, improving accuracy and reducing manual effort.
BACKGROUND
Accurate tumor...
Published: 3/25/2026
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Updated: 2/17/2026
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Inventor(s):
Keywords(s): Artificial Intelligence & Machine Learning, Cancer/Oncology, Diagnostics, Imaging, Lung cancer, Radiotherapy
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Retinoic Acid Agonists for Attenuation of Doxorubicin-Induced Cardiotoxicity
SHORT DESCRIPTION
A method for preventing cardiotoxicity in patients undergoing anthracycline-based chemotherapy using retinoic acid receptor gamma (RARG) agonists.
INVENTORS
Paul W Burridge*, PhD
Associate Professor, Pharmacology, Northwestern University Feinberg School of Medicine
* Principal Investigator
NU...
Published: 2/6/2026
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Updated: 2/6/2026
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Inventor(s):
Keywords(s): Cancer Treatment, Cancer/Oncology, Cardiology and Cardiovascular disease, Chemotherapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Extracellular vesicles for diagnosis and treatment of breast cancer
SHORT DESCRIPTION
Novel methods for detecting cancer through exosome analysis and bioengineered exosomes specifically designed to target cancer stem cells (CSCs).
INVENTORS
Huiping Liu*, MD, PhD
Associate Professor, Pharmacology, Medicine (Hematology and Oncology), Northwestern University Feinberg School...
Published: 2/6/2026
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Updated: 2/6/2026
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Inventor(s):
Keywords(s): Biomarker, Breast cancer, Cancer/Oncology, Diagnostics, Imaging, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Selective DOT1L Protein Degraders for Precision Cancer Therapy
NU 2022-081
INVENTORS
Sarki Abdulkadir (PI)*
Northwestern University Feinberg School of Medicine, Department of Urology
Gary Schiltz (PI)*
Weinberg College of Arts and Sciences, Department of Chemistry
SHORT DESCRIPTION
A small molecule PROTAC technology that degrades DOT1L protein for targeted treatment of leukemia and prostate...
Published: 4/7/2026
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Updated: 2/3/2026
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Cancer/Oncology, Leukemia, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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