|
Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169
INVENTORS
Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN))
Brian Meckes
Wuliang Zhang
SHORT DESCRIPTION
For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 11/7/2025
|
Inventor(s):
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
|
|
A Novel Expander for Drug Delivery in Cancer Patients
NU 2022-129
INVENTORS
John Yah Sung Kim*
Megan Fracol
SHORT DESCRIPTION
This invention offers a tissue expander that integrates drug delivery for breast reconstruction. It provides gradual inflation while releasing therapeutic agents to support improved healing.
BACKGROUND
Implant-based breast reconstruction is the most common method following...
Published: 11/6/2025
|
Inventor(s):
Keywords(s): Cancer/Oncology
Category(s): Life Sciences > Healthcare Devices, Tools & IT
|
|
Covalent MEK4 Inhibitors for Targeted Cancer Therapy
NU 2025-154
INVENTORS
Karl Scheidt*
Gina Connors
SHORT DESCRIPTION
This technology introduces novel covalent inhibitors of MEK4, built upon previously-developed reversible inhibitors (see NU2019-059 and NU2021-217). A covalent inhibition strategy offers enhanced potency, selectivity, and prolonged duration of action compared to reversible...
Published: 11/6/2025
|
Inventor(s):
Keywords(s): Cancer/Oncology, Covalent Inhibition, Kinase Inhibitor, MEK4, MEK7
Category(s): Life Sciences > Therapeutics
|
|
Clinical Bacterial Isolate Engineered as Prostate Cancer Immunotherapy
NU 2015-087
INVENTORS
Praveen Thumbikat*
Anthony Schaeffer
Jonathan Anker
Sarki Abdulkadir
SHORT DESCRIPTION
This technology uses a genetically modified CP1 E. coli as an immunotherapeutic agent for prostate cancer. It offers a non-invasive treatment option designed to stimulate an immune response in both early stage and advanced disease.
BACKGROUND
Existing...
Published: 11/6/2025
|
Inventor(s):
Keywords(s): Cancer/Oncology, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Nanocytological and Molecular Analysis of Fecal Colonocytes for Colon Cancer Screening
NU 2010-131
INVENTORS
Vadim Backman*
Dhwanil Damania
Dhananjay Kunte
Hariharan Subramanian
Hemant Roy
Mart De La Cruz
SHORT DESCRIPTION
This technology offers a novel fecal test that detects nanoarchitectural and molecular markers in colonocytes. It delivers a minimally invasive screening method for early detection of colon cancer.
BACKGROUND
Colorectal...
Published: 11/6/2025
|
Inventor(s):
Keywords(s): Cancer/Oncology, Colon cancer, Diagnostics, Drug screening, Imaging, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
|
|
Targeted Therapy for Glioblastoma via Purine Metabolism Modulation
NU 2019-086
INVENTORS
Atique Ahmed*
Cheol Park
Jack Shireman
SHORT DESCRIPTION
This technology introduces a targeted approach for glioblastoma treatment that modulates purine biosynthesis by targeting the ARL13B-IMPDH2 interaction using repurposed FDA-approved and internationally-used drugs.
BACKGROUND
Glioblastoma is an incurable, aggressive...
Published: 11/6/2025
|
Inventor(s):
Keywords(s): Cancer/Oncology, Repurposed Drugs, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Self-powered, bioresorbable drug release systems
NU 2023-045
INVENTORS
John Rogers*
Colin Franz*
Yamin Zhang
SHORT DESCRIPTION
Northwestern and Shirley Ryan AbilityLab researchers have developed a novel, self-powered, bioresorbable drug delivery system that enables light-controlled, targeted drug release without the need for surgical removal post-treatment.
BACKGROUND
Current drug delivery systems...
Published: 11/6/2025
|
Inventor(s):
Keywords(s): Biomaterials, Cancer/Oncology, Drug delivery, Infectious disease, Medical device, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
|
|
Improved MEK4 Inhibitors for the Treatment of Cancer
NU 2021-217
INVENTORS
Karl Scheidt*
Ada Jade Kwong
Hidayatullah Munshi
Thao Nguyen Pham
SHORT DESCRIPTION
This technology introduces novel indazole derivatives as potent and selective MEK4 inhibitors for cancer treatment, particularly in advanced prostate cancer and pancreatic adenocarcinoma. The lead molecule is optimized over first-generation...
Published: 11/6/2025
|
Inventor(s):
Keywords(s): Cancer/Oncology, Pancreatic cancer, Prostate cancer
Category(s): Life Sciences > Therapeutics
|
|
Simple Formulation of Anaerobic Bacteria to Treat Solid Tumors
NU 2022-219
INVENTORS
Dong-Hyun Kim*
Hyunjun Choi
Bongseo Choi
SHORT DESCRIPTION
A formulation of anaerobic bacteria embedded in embolic material, delivered through transcatheter intra-arterial infusion for treating solid tumors.
BACKGROUND
Non-pathogenic Clostridium novyi (C. novyi-NT) is an anaerobic bacterium capable of selective germination...
Published: 11/6/2025
|
Inventor(s):
Keywords(s): Cancer/Oncology, Materials, Therapeutics
Category(s): Life Sciences > Therapeutics
|
|
Anti-PODXL Antibody for Inhibiting Metastasis in Breast Cancer
NU 2023-110
INVENTORS
Huiping Liu*
Nurmaa Dashzeveg
SHORT DESCRIPTION
This technology introduces methods of use for an anti-PODXL antibody that effectively prevents and treats metastasis in breast cancer by inhibiting circulating tumor cell (CTC) cluster formation.
BACKGROUND
Cancer metastasis is mediated by circulating tumor cells (CTC) and...
Published: 11/6/2025
|
Inventor(s):
Keywords(s): Breast cancer, Cancer/Oncology
Category(s): Life Sciences > Therapeutics
|