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Deep learning for automated, motion-resolved tumor segmentation in radiotherapy
NU2025-264
INVENTORS
Mohamed Abazeed*
Sagnik Sarkar
Peng Thian Troy Teo
SHORT DESCRIPTION
This invention describes a method for automatically outlining lung tumors for radiotherapy planning. It uses deep learning to precisely identify tumors across breathing cycles, improving accuracy and reducing manual effort.
BACKGROUND
Accurate tumor...
Published: 2/17/2026
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Inventor(s):
Keywords(s): Artificial Intelligence & Machine Learning, Cancer/Oncology, Diagnostics, Imaging, Lung cancer, Radiotherapy
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Retinoic Acid Agonists for Attenuation of Doxorubicin-Induced Cardiotoxicity
SHORT DESCRIPTION
A method for preventing cardiotoxicity in patients undergoing anthracycline-based chemotherapy using retinoic acid receptor gamma (RARG) agonists.
INVENTORS
Paul W Burridge*, PhD
Associate Professor, Pharmacology, Northwestern University Feinberg School of Medicine
* Principal Investigator
NU...
Published: 2/6/2026
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Inventor(s):
Keywords(s): Cancer Treatment, Cancer/Oncology, Cardiology and Cardiovascular disease, Chemotherapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Extracellular vesicles for diagnosis and treatment of breast cancer
SHORT DESCRIPTION
Novel methods for detecting cancer through exosome analysis and bioengineered exosomes specifically designed to target cancer stem cells (CSCs).
INVENTORS
Huiping Liu*, MD, PhD
Associate Professor, Pharmacology, Medicine (Hematology and Oncology), Northwestern University Feinberg School...
Published: 2/6/2026
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Inventor(s):
Keywords(s): Biomarker, Breast cancer, Cancer/Oncology, Diagnostics, Imaging, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and neurodegenerative disorders
NU 2025-113 (NU 2018-176, NU 2024-250, NU 2025-038)
INVENTORS
Richard Silverman (Weinberg College of Arts and Sciences, Department of Chemistry)
SHORT DESCRIPTION
Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and other cancers with high expression of nNOS (e.g., gliomas, ovarian cancer)...
Published: 2/6/2026
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Cancer/Oncology, Immunotherapy, Melanoma, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Selective DOT1L Protein Degraders for Precision Cancer Therapy
NU 2022-081
INVENTORS
Sarki Abdulkadir (PI)*
Gary Schiltz (PI)*
SHORT DESCRIPTION
A small molecule PROTAC technology that degrades DOT1L protein for targeted treatment of leukemia and prostate cancer.
BACKGROUND
Current cancer treatments, especially for MLL-rearranged leukemia and prostate cancer, face challenges of off-target effects and...
Published: 2/6/2026
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Cancer/Oncology, Leukemia, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Covalent PRC2 Inhibitors for Advanced Cancer Therapeutics
SHORT DESCRIPTION
Covalent inhibitors and proteolysis-targeting chimera (PROTAC) degraders targeting components of the PRC2 complex (EZH and EED) to block both enzymatic and non-enzymatic functions, offering robust anti-tumor efficacy.
INVENTORS
Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)*
Jindan...
Published: 2/6/2026
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Bladder cancer, Breast cancer, Cancer/Oncology, Covalent inhibitor, Lymphoma, Melanoma, PreSeed/Seed, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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The use of complex or fusion protein of soluble MIC (Smic) and antibody to treat MIC-negative cancer
NU 2019-146
INVENTORS
Jennifer Wu*
SHORT DESCRIPTION
A fusion protein complex comprising soluble MIC and a non-blocking sMIC-neutralizing antibody that effectively activates CD8 T cells for the treatment of MIC-negative cancer.
BACKGROUND
Effective T cell co-stimulation is critical for durable tumor control, yet many current immunotherapies...
Published: 12/9/2025
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Inventor(s):
Keywords(s): Antibody, Cancer/Oncology, Research tool
Category(s): Life Sciences > Therapeutics
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Engineered B-cell Therapy for Cancer Treatment
NU 2022-218
INVENTORS
Catalina Lee Chang*
Maciej Lesniak*
SHORT DESCRIPTION
Engineered B cells with reduced expression of key immune checkpoint proteins designed to boost cancer immunotherapy efficacy.
BACKGROUND
Immunotherapy has transformed cancer treatment; however, its application to brain tumors remains limited by the immunosuppressive...
Published: 12/3/2025
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Inventor(s):
Keywords(s): Cancer/Oncology
Category(s): Life Sciences > Therapeutics
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New Therapeutic Approach for the Treatment of Acute Myeloid Leukemia
NU 2017-214
Inventors
Ali Shilatifard*
Zibo Zhao
Short Description
A new therapeutic approach for the treatment of acute myeloid leukemia using casein kinase inhibitors.
Background
Leukemia is a group of cancers that affects the bone marrow and results in the overproduction of dysfunctional white blood cells (WBCs). The mixed lineage leukemia...
Published: 11/18/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Therapeutics
Category(s): Life Sciences > Therapeutics
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Compounds and methods for FBXW7-R465C-mediated protein degradation
NU 2024-224
INVENTORS
Xiaoyu Zhang*
Ananya Basu
SHORT DESCRIPTION
This invention describes novel heterobifunctional compounds that exploit a somatic mutant of the FBXW7 E3 ligase for targeted protein degradation.
BACKGROUND
Targeted protein degradation (TPD) is a powerful therapeutic strategy that harnesses the cell's natural machinery...
Published: 2/6/2026
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Inventor(s):
Keywords(s): AUTM26_1, Cancer/Oncology, PROTAC
Category(s): Life Sciences > Therapeutics
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