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Platelet Factor 4 as a Biomarker of Defective Lymphatics
NU 2020-158
INVENTORS
Guillermo Oliver*
Stanley Rockson
SHORT DESCRIPTION
A new biomarker for identifying lymphatic vasculature diseases
BACKGROUND
Lymphatic vasculature defects often result in disfiguring, disabling, and, occasionally, life-threatening outcomes. Diagnostic tools for all of the lymphatic disorders are relatively limited, relying...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Assay, Biomarker, Diagnostics, Obesity, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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HPS1 and HPS4 Function as RNAi Inhibitors: A Means to Boost RNAi for Experimental, Therapeutic & Commercial Purposes
NU 2005-063BInventorsRichard Carthew* Dinari Harris Young Sik Lee Short DescriptionNovel strategy to improve gene silencing by RNAi for development of therapeutics AbstractRNAi has been proposed as a therapeutic strategy for disorders characterized by aberrant gene overexpression (cancer, macular degeneration etc.) as well as for controlling viral infections....
Published: 11/6/2025
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Inventor(s):
Keywords(s): Assay, Biologic, Gene therapy, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Therapeutics
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Irreversible tethering method for screening for covalent inhibitors of enzymes
NU 2014-002 InventorsAlexander V. Statsyk* Stefan G. Kathman Short DescriptionAn unbiased library of compounds was generated using a one-step method in order to screen for covalent inhibitors of enzymes AbstractEnzyme inhibitors that covalently modify their target are gaining in popularity due to their high potency even at low doses and lack of susceptibility...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Assay, Biomedical, Drug discovery, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Nanoscale Subsurface Imaging via Scanning Near-Field Ultrasound Holography
NU 2003-061 and 2010-051 InventorsGajendra S. Shekhawat* Vinayak P. Dravid Short DescriptionA novel nondestructive imaging method (SNFUH) providing nanoscale spatial resolution as well as depth information for embedded structural features. AbstractThere is an increasing need for nondestructive high-resolution imaging of various 'buried' nano/micro-structures...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Assay, Devices, Imaging, Instrumentation, Materials, Optics
Category(s): Physical Sciences > Materials and Industrial Processes
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High Speed/Low Dose Multi-Objective Autonomous Scanning Materials Imaging
NU 2017-129 Inventors Karl A. Hujsak Vinayak P. Dravid* Short Description A software package that captures and reconstructs images for electron microscopy analysisBackground Electron microscopy (EM) is fundamental to the study of the structure and composition of micro- to nanometer-structured materials. This length scale encompasses cells, proteins,...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Analysis, Application, Assay, Computer software, Engineering, Instrumentation, Microscopy, Mobile app
Category(s): Physical Sciences > Engineering & Technology
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Non-Contact Liquid Droplet Manipulation Method
NU 2015-147 InventorsPaul Umbanhowar* Kevin Lynch Short DescriptionA microfluidic method of levitating and controlling the position and motion of a droplet above a surface AbstractNorthwestern researchers have developed a microfluidic method that allows scientists to manipulate nanoliter-scale droplets for a variety of applications. The ability to work...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Assay, Devices, Health IT, Instrumentation, Medical device
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Probes and Assays for Measuring E3 Ligase Activity
NU 2014-118 InventorsAlexander V. Statsyuk*Sung Jin Park Short DescriptionCompositions and methods for studying protein ubiquitination and developing therapeutics to modulate protein ubiquitinationBackgroundProtein ubiquitination is a highly conserved post-translational modification that regulates fundamental cellular processes. Ubiquitin conjugation...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Assay, Biomedical, Drug screening, Research reagent, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Proof of Concept of Engineering a Yeast Receptor to Detect New Peptide Ligands
NU 2014-053 InventorsKeith Tyo* Dante Pertusi John Bostick Adebola Adeniran Short DescriptionA low-cost diagnostic platform for protein detection AbstractNorthwestern University researchers have developed a platform for creating yeast-based, low-cost diagnostics with novel detection capabilities. While existing lateral flow devices (e.g. pregnancy tests)...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Assay, COVID-19, Diagnostics, Imaging, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Enhancing Gene Expression for Gene Therapy
NU 2007-020 InventorsDavid Dean* R. Christopher Geiger Short DescriptionNovel method for increasing gene transfer by inhibition of histone deacetylase enzymes AbstractNorthwestern researchers have developed a method for improving gene expression of genes delivered for therapeutic applications. One of the main obstacles to establishing effective non-viral...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Assay, Gene therapy, Research reagent, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Therapeutics
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Method for Performing and Analyzing Multiplexed Bead-Based Assays
NU 2006-022 InventorsAbhishek Mathur David M. Kelso* Short DescriptionNovel system and method for performing high throughput bead-based assays for multiple analytes simultaneously AbstractNorthwestern researchers have developed a method for performing high throughput bead-based assays by establishing a fluorophore-based bar coding system for microbeads....
Published: 11/6/2025
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Inventor(s):
Keywords(s): Assay, Devices, Diagnostics, Medical device, Microscopy, Research tool
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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