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Neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and neurodegenerative disorders
NU 2025-113 (NU 2016-137, NU 2018-176, NU 2019-179, NU 2023-007, NU 2024-250, NU 2025-038)
INVENTORS
Richard Silverman (Weinberg College of Arts and Sciences, Department of Chemistry)
SHORT DESCRIPTION
Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and other cancers with high expression...
Published: 4/1/2026
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Updated: 4/1/2026
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Inventor(s):
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, AUTM26C1, BIAUTM1, Cancer/Oncology, Cardiology and Cardiovascular disease, Immunodeficiency, Immunology, Immunotherapy, Melanoma, Neurodegenerative disease, Neuroinflammation, nNOS, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Targeting EGFR Co-Amplified Long-Noncoding RNA for Glioblastoma Treatment
NU 2025-335
INVENTORS
Shi-Yuan Cheng*
Xiaozhou Yu
Bo Hu
Runxin Wu
Xiao Song
SHORT DESCRIPTION
This invention provides compositions and methods for inhibiting ELDR and HELDR, two long non-coding RNAs (lncRNAs) that are frequently co-amplified in glioblastoma (GBM) with the epidermal growth factor receptor (EGFR) gene, and which drive tumorigenesis...
Published: 3/30/2026
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Updated: 3/30/2026
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Inventor(s):
Keywords(s): Brain cancer, Cancer Treatment, Cancer/Oncology, Therapeutics
Category(s): Life Sciences > Therapeutics
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Noninvasive brain-specific inhibition of bone morphogenetic protein signaling for the prevention of tauopathy
NU2025-330
INVENTORS
John Kessler*
Justin Geier
Chian-Yu Peng
SHORT DESCRIPTION
This invention uses a noninvasive gene therapy approach to prevent and treat tauopathies, such as Alzheimer's disease and frontotemporal dementia, by inhibiting bone morphogenetic protein (BMP) specifically within the central nervous system.
BACKGROUND
Tauopathies...
Published: 3/27/2026
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Updated: 3/26/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Gene therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Targeted pH Sensitive Liposomes
NU 2020-170
INVENTORS
Leo Gordon*
Dong-Hyun Kim*
Shuo Yang
Wooram Park
Taehoon Sim
SHORT DESCRIPTION
Liposomal nanoparticles composed of pH-sensitive lipids and apolipoprotein that encapsulate andrographolide for lymphoma treatment.
BACKGROUND
Lymphoma, particularly diffuse large B-cell lymphoma (DLBCL), is the most common aggressive type...
Published: 3/11/2026
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Updated: 3/11/2026
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Inventor(s):
Keywords(s): Blood & Lymphatic disease, Cancer/Oncology, Nanoparticle, Therapeutics
Category(s): Life Sciences > Therapeutics
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Aminopyrimidine-based Kinase Inhibitors for Treatment of Cancer
NU 2015-098
Inventors
Leonidas C. Platanias*
Gary E. Schiltz
Rama K. Mishra
Short Description
A small molecule to treat glioblastoma multiforme by blocking the Mnk pathway.
Background
Glioblastoma multiforme (GBM) is an aggressive brain cancer associated with a low survival rate, high recurrence, and limited therapeutic options. Most diagnosed...
Published: 3/5/2026
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Updated: 3/5/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Covalent PRC2 Inhibitors for Advanced Cancer Therapeutics
SHORT DESCRIPTION
Covalent inhibitors and proteolysis-targeting chimera (PROTAC) degraders targeting components of the PRC2 complex (EZH and EED) to block both enzymatic and non-enzymatic functions, offering robust anti-tumor efficacy.
INVENTORS
Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)*
Jindan...
Published: 4/7/2026
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Updated: 3/5/2026
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Bladder cancer, Breast cancer, Cancer/Oncology, Covalent inhibitor, Lymphoma, Melanoma, PreSeed/Seed, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Inhibition of BACH1 for pulmonary arterial hypertension therapy
LU 2024-222
INVENTORS
Youyang Zhao*
SHORT DESCRIPTION
This invention identifies a protein called BACH1 as a key driver of pulmonary arterial hypertension (PAH). By targeting and inhibiting BACH1, particularly in the pulmonary endothelium, this technology provides methods for preventing or reversing the abnormal thickening of pulmonary vasculature,...
Published: 3/5/2026
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Updated: 3/5/2026
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Inventor(s):
Keywords(s): Cardio-Pulmonary, Pulmonary disease, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Antibodies for treatment of coronavirus disease
NU 2023-247
INVENTORS
Huiping Liu*
Deyu Fang*
Hannah Mubarak
Andrew Hoffmann
Nurmaa Dashzeveg
Lamiaa El-Shennawy
Juncheng Wei
Wuwei Tan
Yang Shen
SHORT DESCRIPTION
Computationally redesigned antibodies targeting SARS-CoV-2 for treating COVID-19.
BACKGROUND
The continuous evolution of SARS-CoV-2 has allowed the virus to escape most therapeutic...
Published: 2/26/2026
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Updated: 2/26/2026
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Inventor(s):
Keywords(s): Antibody, Artificial Intelligence & Machine Learning, Biologic, Infectious disease, Research tool, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Aqueous Formulations of Cytotoxic Taxanes with Cyclodextrin
NU 2022-109
INVENTORS
Brittney Williams
Matthew Thompson
Nathan Gianneschi*
SHORT DESCRIPTION
This invention describes aqueous formulations of cytotoxic taxane drugs conjugated to fatty acids, solubilized using cyclodextrin inclusion complexes, providing water-soluble chemotherapy formulations that eliminate the need for toxic organic solvents...
Published: 2/26/2026
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Updated: 2/25/2026
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Inventor(s):
Keywords(s):
Category(s): Life Sciences > Therapeutics
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Methods of Using Modified Cytotoxins to Treat Cancer
NU 2019-135
INVENTORS
Nathan Gianneschi*
SHORT DESCRIPTION
Methods for treating cancers that overexpress fatty acid uptake proteins using small-molecule cytotoxic drugs conjugated to long-chain fatty acid moieties. See also NU2022-111 and NU2022-109.
BACKGROUND
While prior work (under NU2022-111) demonstrated that lipid-mimicking cytotoxin...
Published: 2/26/2026
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Updated: 2/25/2026
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Inventor(s):
Keywords(s): Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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