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A transient closed-loop system
PROPOSED TITLE (cut & paste into Alternate Title): Transient Closed-Loop System for Autonomous Cardiac Electrotherapy
NU NUMBER NU 2021-255
INVENTORS
Igor Efimov*
John Rogers*
Hyoyoung Jeong
Rose Yin
Yeonsik Choi
SHORT DESCRIPTION
For cardiac care providers, this novel system integrates wireless, body-integrated devices to provide autonomous,...
Published: 12/9/2025
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Inventor(s):
Keywords(s):
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
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The use of complex or fusion protein of soluble MIC (Smic) and antibody to treat MIC-negative cancer
NU 2019-146
INVENTORS
Jennifer Wu*
SHORT DESCRIPTION
A fusion protein complex comprising soluble MIC and a non-blocking sMIC-neutralizing antibody that effectively activates CD8 T cells for the treatment of MIC-negative cancer.
BACKGROUND
Effective T cell co-stimulation is critical for durable tumor control, yet many current immunotherapies...
Published: 12/9/2025
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Inventor(s):
Keywords(s): Antibody, Cancer/Oncology, Research tool
Category(s): Life Sciences > Therapeutics
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Engineered B-cell Therapy for Cancer Treatment
NU 2022-218
INVENTORS
Catalina Lee Chang*
Maciej Lesniak*
SHORT DESCRIPTION
Engineered B cells with reduced expression of key immune checkpoint proteins designed to boost cancer immunotherapy efficacy.
BACKGROUND
Immunotherapy has transformed cancer treatment; however, its application to brain tumors remains limited by the immunosuppressive...
Published: 12/3/2025
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Inventor(s):
Keywords(s): Cancer/Oncology
Category(s): Life Sciences > Therapeutics
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The Use of Annexins in Preventing and Treating Muscle Membrane Injury
NU 2018-119
INVENTORS
Elizabeth McNally*
Alexis Demonbreun
SHORT DESCRIPTION
An annexin-based biological therapeutic that enhances the body's natural cell membrane repair process to reduce muscle cell death and preserve tissue function.
BACKGROUND
Cell membrane integrity is critical for survival, especially in tissues under constant mechanical...
Published: 12/9/2025
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Inventor(s):
Keywords(s): Neurodegenerative disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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New Therapeutic Approach for the Treatment of Acute Myeloid Leukemia
NU 2017-214
Inventors
Ali Shilatifard*
Zibo Zhao
Short Description
A new therapeutic approach for the treatment of acute myeloid leukemia using casein kinase inhibitors.
Background
Leukemia is a group of cancers that affects the bone marrow and results in the overproduction of dysfunctional white blood cells (WBCs). The mixed lineage leukemia...
Published: 11/18/2025
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Inventor(s):
Keywords(s): Cancer/Oncology, Therapeutics
Category(s): Life Sciences > Therapeutics
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Arylazanylpyrazolone Inhibition of Mutant SOD1 Mediated Cytotoxicity and Application to the Treatment of ALS
✅ Feedback form for Tech ID 2012-178
PROPOSED TITLE: Arylazanylpyrazolone Inhibition of Mutant SOD1 Cytotoxicity for ALS Treatment
NU 2012-178
INVENTORS
Richard Silverman*
Yinan Zhang
SHORT DESCRIPTION
Compounds based on arylazanylpyrazolone derivatives inhibit mutant SOD1-mediated cytotoxicity, offering a promising approach for ALS treatment.
BACKGROUND
Amyotrophic...
Published: 11/18/2025
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Inventor(s):
Keywords(s): Therapeutics
Category(s): Life Sciences > Therapeutics
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2-(Pyridin-3-yl)quinazoline compounds as glucocerebrosidase modulators
✅ Feedback form for Tech ID 2015-064
PROPOSED TITLE: 2-(Pyridin-3-yl) quinazoline Compounds as Glucocerebrosidase Modulators
NU 2015-064
INVENTORS
Richard Silverman*
Dimitri Krainc
Jianbin Zheng
SHORT DESCRIPTION
Novel substituted quinazoline compounds that modulate glucocerebrosidase activity, offering a promising therapeutic approach for...
Published: 11/18/2025
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Inventor(s):
Keywords(s): Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Research tool, Therapeutics
Category(s): Life Sciences > Therapeutics
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Development of Therapeutics for Amyotrophic Lateral Sclerosis (ALS)
NU 2008-163 and NU2009-098
Inventors
Richard B. Silverman*
Richard Morimoto
P. Hande Ozdinler
Short Description
Three series of New Chemical Entities (NCEs) that exhibit efficacy in an ALS animal model
Background
ALS causes muscle weakness and atrophy due to the degeneration of the upper and lower motor neurons. This disease is both genetic...
Published: 11/18/2025
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Inventor(s):
Keywords(s): Neurodegenerative disease, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Pyrimidine-2,4,6-Trione Derivatives Preparation and Their Use for the Treatment of Amyotrophic Lateral Sclerosis (ALS) ALS Therapy
NU 2009-072
INVENTORS
Richard Morimoto*
Richard Silverman*
Gavin Guoyao Xia
SHORT DESCRIPTION
This invention discloses novel pyrimidine-2,4,6-trione derivatives (PYT compounds) that prevent abnormal protein aggregation associated with ALS, offering a promising new therapeutic approach for neurodegenerative diseases.
BACKGROUND
Amyotrophic...
Published: 11/18/2025
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Inventor(s):
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, Neurodegenerative disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Compounds and methods for FBXW7-R465C-mediated protein degradation
NU 2024-224
INVENTORS
Xiaoyu Zhang*
Ananya Basu
SHORT DESCRIPTION
This invention describes novel heterobifunctional compounds that exploit a somatic mutant of the FBXW7 E3 ligase for targeted protein degradation.
BACKGROUND
Targeted protein degradation (TPD) is a powerful therapeutic strategy that harnesses the cell's natural machinery...
Published: 11/18/2025
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Inventor(s):
Keywords(s):
Category(s): Life Sciences > Therapeutics
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