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ACE2+ Exosomes for COVID-19 Decoy Therapy
PROPOSED TITLE: ACE2+ Exosomes for COVID-19 Decoy Therapy
NU NUMBER NU 2020-145
INVENTORS
Deyu Fang*
Huiping Liu*
Andrew Hoffmann
Emma June Schuster
Lamiaa El-Shennawy
Nurmaa Dashzeveg
SHORT DESCRIPTION
This invention provides exosomes loaded with ACE2 protein or viral antigen-specific IgGs for treatment of COVID-19.
BACKGROUND
The COVID-19...
Published: 11/17/2025
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Inventor(s):
Keywords(s): COVID-19, Drug delivery, Infectious disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Efficient Chromane Synthesis via Photoredox/Lewis Acid Cooperative Catalysis
NU 2019-062
INVENTORS
Karl Scheidt*
Benjamin McDonald
Richard Betori
SHORT DESCRIPTION
This technology provides a novel cooperative photoredox and Lewis acid catalytic approach to synthesize chromane scaffolds with high yield and stereoselectivity. It targets clinical development and natural product synthesis.
BACKGROUND
Chromanes are essential...
Published: 11/17/2025
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Inventor(s):
Keywords(s):
Category(s): Life Sciences > Therapeutics
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Targeting the IFITM1/OVOL1 Axis for Treating Corneal Wounds
NU 2024-159
INVENTORS
Han Peng*
Robert Lavker
SHORT DESCRIPTION
This invention addresses corneal wound healing by providing methods and compositions to target the IFITM1/OVOL1 axis to modulate limbal epithelial stem cells (LESCs) and early transit amplifying cells (eTAs).
BACKGROUND
Maintaining corneal transparency and vision depends on...
Published: 11/10/2025
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Inventor(s):
Keywords(s):
Category(s): Life Sciences > Therapeutics
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Potent and selective Cav1.3 negative allosteric modulators for use in Parkinson's Disease
NU 2010-105 and NU 2024-179
INVENTORS
Richard Silverman* (Northwestern University, Weinberg College of Arts & Science, Department of Chemistry)
Dalton Surmeier Jr.* (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience)
Garry Cooper
Soosung Kang
Jack Nguyen
SHORT DESCRIPTION
For pharmaceutical...
Published: 11/11/2025
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Inventor(s):
Keywords(s): Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
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Closed-Loop Implantable System for Automated Opioid Overdose Detection and Reversal
NU 2019-073
INVENTORS
John Rogers (Northwestern University)*
Robert Gereau (Washington University, St Louis)*
SHORT DESCRIPTION
This wireless device, the size of a pacemaker, is implanted to monitor oxygen levels. Below a specific threshold, it sends an alert to warning notification on a mobile app, then automatically releases naloxone to prevent...
Published: 11/7/2025
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Inventor(s):
Keywords(s): Drug delivery, Electronics & Circuits, Medical device, Microfluidics
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
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A platform for mapping reactive cysteines within the immunopeptidome
NU 2024-044
INVENTORS
Xiaoyu Zhang*
Chenlu Zhang
Chen Zhou
SHORT DESCRIPTION
This invention provides novel chemical probes for mapping reactive cysteine residues within the major histocompatibility complex class I (MHC-I) immunopeptidome.
BACKGROUND
The immune system's recognition of infected or malignant cells hinges on the presentation...
Published: 11/6/2025
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Inventor(s):
Keywords(s):
Category(s): Life Sciences > Therapeutics
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Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169
INVENTORS
Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN))
Brian Meckes
Wuliang Zhang
SHORT DESCRIPTION
For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 11/7/2025
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Inventor(s):
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
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Cord Blood Protein Biomarkers to Identify Early-Onset Neonatal Sepsis
LNU 2024-090
INVENTORS
Leena Mithal*
SHORT DESCRIPTION
A diagnostic assay developed using proteomic biomarkers from umbilical cord blood to rapidly risk stratify newborns for early-onset neonatal sepsis, enabling targeted antibiotic therapy and improved outcomes.
BACKGROUND
Current approaches to diagnose early-onset sepsis rely on postnatal...
Published: 11/6/2025
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Inventor(s):
Keywords(s):
Category(s): Life Sciences > Therapeutics
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TauSeeK: Disease Specific Tau Protein Fibrils & Seeding Proteins
NU 2024-154
INVENTORS
Songi Han*
Austin Dubose
Michael Vigers
Andrew Longhini
Vishnu Vijayan
Kenneth Kosik
Samuel Lobo
Peter C. Ryffel
Lokeswara Rao Potnuru
Karen Tsay
Chung-Ta Han
SHORT DESCRIPTION
Compositions, kits, and methods for generating synthetic miniature tau peptides and fibrils, and synthetic full-length pathogenic tau...
Published: 11/6/2025
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Inventor(s):
Keywords(s):
Category(s): Life Sciences > Therapeutics
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Covalent ATG4B Inhibitors for Treatment of Cancer
NU2025-186
INVENTORS
Karl Scheidt*
Claire Trudeau
Shiyuan Cheng
SHORT DESCRIPTION
The invention introduces a novel class of peptidyl covalent reversible ketoamide inhibitors designed to target the cysteine protease ATG4B.
BACKGROUND
Glioblastoma (GBM) is an aggressive and highly malignant tumor of the central nervous system, characterized...
Published: 11/6/2025
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Inventor(s):
Keywords(s):
Category(s): Life Sciences > Therapeutics
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