NU 2012-153

Inventors

Debabrata Chakravarti* 

John Brandon Parker 

Santanu Palchaudhuri 

Abstract

Thanatos-associated protein (THAP) contains an atypical zinc finger motif with sequence-specific DNA-binding activity. Emerging data suggest that THAP proteins may function in chromatin-dependent processes, including transcriptional regulation. The roles of most THAP proteins in normal and aberrant cellular processes remain largely unknown. THAP11 has been identified as a transcriptional regulator differentially expressed in human colon cancer. Northwestern University Researchers have developed a rabbit antibody against THAP11. pAb THAP11 (976) was developed using a GST-THAP11 fusion protein as an immunogen and is able to recognize human THAP11 in ChIP, IHC, IP, and Western Blot (MW: 53kDa) techniques. 

Applications

• Chromatin research
• Transcription research

Advantages

• Demonstrated to recognize the target protein when used in various techniques