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Compounds and methods for FBXW7-R465C-mediated protein degradation
NU 2024-224
INVENTORS
Xiaoyu Zhang*
Ananya Basu
SHORT DESCRIPTION
This invention describes novel heterobifunctional compounds that exploit a somatic mutant of the FBXW7 E3 ligase for targeted protein degradation.
BACKGROUND
Targeted protein degradation (TPD) is a powerful therapeutic strategy that harnesses the cell's natural machinery...
Published: 2/6/2026
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Inventor(s):
Keywords(s): AUTM26_1, Cancer/Oncology, PROTAC
Category(s): Life Sciences > Therapeutics
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NU-CATS risk score for endometrial cancer prognosis
NU 2023-107
INVENTORS
Shuhua Zheng*
Eric Donnelly
Jonathan Strauss
SHORT DESCRIPTION
Machine learning-based new unified risk classification score (NU- CATs) for patients with endometrial cancer.
BACKGROUND
Clinically relevant classification of endometrial cancer is important for prognosis and predictions of treatment success. Traditionally,...
Published: 2/6/2026
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Inventor(s):
Keywords(s): Artificial Intelligence & Machine Learning, AUTM26_1, Cancer/Oncology, Diagnostics, Endometrial cancer
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Physical Sciences > Software & Services
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Compounds and methods of identifying novel E3 ligases for targeted protein degradation
NU 2023-096
INVENTORS
Ananya Angela Basu
Xiaoyu Zhang*
SHORT DESCRIPTION
A CRISPR-activation screen for discovering E3 ligases amenable to targeted protein degradation, and a novel PROTAC for FBXO22
BACKGROUND
Traditional small molecule drugs function by directly interfering with the activities of proteins. However, many proteins lack suitable...
Published: 2/6/2026
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Inventor(s):
Keywords(s): AUTM26_1, Drug discovery, Proteomics, Small molecule
Category(s): Life Sciences > Therapeutics
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