NU 2023-078

INVENTORS
Cheng Sun*
Hao Zhang*
Alex Huang
Raymond Fang
Pengpeng Zhang
Tingwei Zhang

SHORT DESCRIPTION
A robotic visible-light optical coherence tomography (OCT) system designed for comprehensive imaging of the anterior segment of the eye, introducing novel computational alignment algorithms and a lightweight OCT sample arm for enhanced imaging capabilities.

BACKGROUND
We developed a robotic visible-light OCT system targeting the anterior segment of the eye, marking a pioneering application of robotic OCT for imaging the cornea and limbus. This system features a compact, lightweight OCT sample arm and leverages computational algorithms to align the robotic arm's tool reference frame with the eye's reference frame, addressing the need for detailed, non-invasive eye examinations.

ABSTRACT
This technology comprises a robotic OCT system for the anterior segment of the eye, utilizing visible light for detailed imaging. It represents a significant advancement in ocular imaging, offering a novel approach to aligning the imaging system with the eye's anatomy for enhanced resolution and image quality. The system's design facilitates a range of applications in ocular health, from surgery planning to treatment monitoring, through its innovative use of robotic technology and computational algorithms.

APPLICATIONS

• 360-degree imaging of the conventional outflow pathway for microinvasive glaucoma surgery

• Monitoring of the palisades of Vogt for dry eye disease treatment

• Evaluation of surgical and pharmacological treatment effectiveness on the anterior eye segment

• Detailed imaging for a better understanding of segmental outflow patterns in glaucoma

• High-resolution tear film layer imaging

• Enhanced lateral resolution in the anterior eye segment through multiple angle scanning

• Custom 3D eye modeling and printing for ocular device design

• 3D conformal scanning of the cornea for precise structural feature imaging

ADVANTAGES

• Improved anisotropic lateral resolution through multiple scanning angles

• Enhanced visualization of critical structures like Schlemm's Canal and palisades of Vogt

• Ability to capture images without requiring large-angle eye fixation by participants

• Reduced acquisition times for anterior segment scans

• Design ensures normal incidence to anatomy, increasing signal-to-noise ratio

• Full 360-degree imaging capability for comprehensive outflow pathway exploration

IP STATUS
US Patent Pending