NU 1992-001 

Inventors 

Alisa E Koch 

Short Description

Research reagents for detection of synovial macrophages

Abstract

Northwestern researchers have developed three mouse antibodies (mAb 1069, mAb 1067 and mAb 8H2) against target proteins on the surface of macrophage cells found in tissues affected with rheumatoid arthritis (RA). RA is an autoimmune disorder that affects small joints in hands and feet. Immune cells called macrophages are central to RA development, and for this reason they have been extensively studied in laboratories around the world. RA is a progressive and debilitating illness that can lead to bone erosion and joint deformities. Therefore, enabling further research into RA and macrophages is of utmost importance to public health. The antibodies generated by Dr. Koch will enable new lines of inquiry into RA, which have the potential to help patients worldwide. 

Applications

• Studies of macrophages and endothelial cells in research settings
• Studies of macrophage contribution to rheumatoid arthritis

Advantages

• New and distinct antigens are recognized
• Standard conditions are used for production

Publications

Koch AE, Burrows JC, Domer PH, Ashmun RA, Look AT, Leibovich SJ (1992) Monoclonal antibodies defining shared human macrophage-endothelial antigens. Pathobiology. 60: 59-67.