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Ultrasensitive and High-Throughput Single Cell RNA Sequencing Technology
NU 2024-199
INVENTORS
Yogesh Goyal*
Emanuelle Grody
Elena Martinelli
SHORT DESCRIPTION
The technology, called SALVE (Single-cell Amplified Libraries for Variant isoform Enrichment)-seq, is an innovative experimental and computational workflow designed to detect rare RNA isoforms in single cells. Compared to existing single cell RNA sequencing...
Published: 5/21/2026
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Updated: 5/21/2026
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Inventor(s):
Keywords(s):
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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A Biosensor Engineering Strategy for Improved Cell-based Therapy
NU 2016-174
Inventors
Joshua N. Leonard*
Kelly A. Schwarz
Rachel M. Dudek
Short Description
A sophisticated multiplexed biosensor system that can activate a downstream promoter to effect diverse custom biological functions. #therapeutics #cellsignaling #healthcare #diagnostictool
Background
The market for cell-based therapeutics has gained wide...
Published: 5/12/2026
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Updated: 5/12/2026
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Inventor(s):
Keywords(s): Biotechnology, Cell therapy, Research tool, Sensors, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Northwestern Startup: Syenex, Inc.
Northwestern Inventor:
Joshua Leonard
McCormick School of Engineering
Chemical and Biological Engineering
Syenex builds bioengineering technologies to unlock the future of human health. Leveraging the power of synthetic biology, we design scalable, precision-engineered components, empowering cell and gene therapy developers to cure disease and build...
Published: 5/5/2026
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Updated: 5/5/2026
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Inventor(s):
Keywords(s): Biologic, Biomedical, Drug delivery, Gene therapy, Platform technology, Research tool, Startup with Northwestern IP, Synthetic biology, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Therapeutics
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Protecting Proprietary Designs via Adversary-Aware Decoy Generation
SHORT DESCRIPTION
A computational tool that safeguards proprietary protein designs by generating biochemically plausible decoy proteins to mislead adversaries.
INVENTORS
V.S. Venkatramanan Subrahmanian, PhD*
Walter P. Murphy Professor of Computer Science, Department of Computer Science, McCormick School of Engineering,...
Published: 5/1/2026
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Updated: 5/1/2026
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Inventor(s):
Keywords(s): Artificial Intelligence & Machine Learning, Biotechnology
Category(s): Physical Sciences > Software & Services, Physical Sciences > Engineering & Technology, Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT
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GDNF-Mimetic Self-Assembling Supramolecular Nanostructure to Enhance Survival and Function of Dopaminergic Neurons for Treatment of Parkinson's Disease
NU 2024-175
SHORT DESCRIPTION
A self-assembling bioactive matrix that presents GDNF-mimetic peptides to support the viability, maturation, and function of dopaminergic neurons in cell replacement therapy for treatment of Parkinson’s Disease.
INVENTORS
Samuel Stupp*
Weinberg College of Arts and Sciences, Department...
Published: 5/11/2026
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Updated: 4/30/2026
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Inventor(s):
Keywords(s): Biologic, Biomaterials, Cell delivery, CNS - Central Nervous System, CVA - Cerebrovascular Accident, Nanomaterials, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Scaffold, SCI - Spinal cord injury, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT > Neurology
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Bioactive, Conductive, and Antioxidant Supramolecular Polymer Hydrogels for Neural Applications
SHORT DESCRIPTION
Biomaterial scaffold for neural cell culture and therapeutic implants that harnesses bioactive, conductive, and antioxidant properties to boost neural cell viability and maturation.
INVENTORS
Samuel Stupp*
Weinberg College of Arts and Sciences, Department of Chemistry
Anna Metlushko
Bo...
Published: 5/11/2026
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Updated: 4/30/2026
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Inventor(s):
Keywords(s): Biologic, Biomaterials, CNS - Central Nervous System, Implantable devices, Neurology, Regenerative medicine, Scaffold, SCI - Spinal cord injury, Smart/Functional materials
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT > Neurology, Life Sciences > Therapeutics
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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION
Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma.
INVENTORS
Amy Heimberger*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
* Principal Investigator
NU Tech ID: NU 2025-212
IP...
Published: 5/7/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets
SHORT DESCRIPTION
A targeted-protein degradation platform for intracellular targets, addressing resistant oncogenic and neurodegenerative targets.
INVENTORS
Shana Kelley*
Weinberg College of Arts & Sciences, Department of Chemistry
Yi Li
* Principal Investigator
NU Tech ID: NU 2025-050
IP...
Published: 5/7/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Biologic, Biomolecular condensates, Cancer/Oncology, Drug delivery, Nanoparticle, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Platform technology, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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N-desmethyl Tamoxifen and Derivatives for Effective Pain Relief
SHORT DESCRIPTION
A novel state-dependent tamoxifen‑derived small molecule anti-pain medication that selectively blocks peripheral voltage‑gated sodium channels to deliver potent, non‑opioid analgesia in chronic and inflammatory pain.
INVENTORS
Paul DeCaen*
Northwestern University Feinberg School of Medicine, Department...
Published: 5/13/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): Chronic pain, Neurology, Non-opioid, Pain management, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Orthogonal Synthetic Receptors for IL-23
SHORT DESCRIPTION
Synthetic IL-23 receptors for cell engineering to enable real-time sensing and drive precise autoimmune and cancer immunotherapy interventions.
INVENTORS
Joshua Leonard*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Aaron Morris
William Corcoran
...
Published: 5/8/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Autoimmune disease, Cell engineering, Cell therapy, Diagnostics, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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